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  • Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV
    Patent number: 8173767
    Abstract: The present invention relates to peptides, referred to as CBD-1, CBD-2, CBM-1/TH-1, CBM-1/TH-2, CBM-2/TH-1, CBM-2/TH-2 and C-20 peptides, which are antigenic and elicit a protective immune response against HIV infection. Compositions, pharmaceutical compositions and vaccines comprising these antigenic peptides are also encompassed by the present invention, as well as neutralizing antibodies which inhibit infection of primary CD4+ T lymphocytes by various HIV isolates. Methods for diagnosis of HIV are also disclosed.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: May 8, 2012
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Ara Hovanessian, Jean-Paul Briand, Sylviane Muller, Bernard Krust, Josette Svab, Elias Said
  • Novel synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV
    Publication number: 20100247618
    Abstract: The present invention relates to peptides, referred to as CBD-1, CBD-2, CBM-1/TH-1, CBM-1/TH-2, CBM-2/TH-1, CBM-2/TH-2 and C-20 peptides, which are antigenic and elicit protective immune response against HIV infection. Compositions, pharmaceutical compositions and vaccines comprising these antigenic peptides are also encompassed by the present invention, as well as neutralizing antibodies which inhibit infection of primary CD4+ T lymphocytes by various HIV isolates. Methods for diagnosis of HIV are also disclosed.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 30, 2010
    Inventors: Ara Hovanessian, Jean Paul Briand, Sylviane Muller, Bernard Krust, Josette Svab, Elias Said