Abstract: The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 267 to Cysteine. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.
Type:
Grant
Filed:
May 6, 2020
Date of Patent:
November 29, 2022
Inventors:
Annika Kraemer-Kuehl, Thomas Min Stephan, Hans-Christian Philipp
Abstract: The invention provides methods and means for distinguishing FECV and FIPV, and methods and means for determining whether FIPV is present in a sample. Further provided are primers and probes for detecting FIPV specific nucleic acid sequences encoding a spike protein, antibodies for detecting a FIPV, and an immunogenic composition and use thereof for eliciting an immune response against a feline coronavirus, preferably a FIPV.
Type:
Application
Filed:
January 18, 2011
Publication date:
March 21, 2013
Applicant:
Universiteit Utrecht Holding B.V.
Inventors:
Petrus Josephus Marie Rottier, Hui-Wen Chang, Herman F. Egberink
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