Search Patents
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Publication number: 20040053910
    Abstract: The present invention provides compounds of formula (I): 1
    Type: Application
    Filed: May 9, 2003
    Publication date: March 18, 2004
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Publication number: 20030176368
    Abstract: The present invention provides compounds of formula (I): 1
    Type: Application
    Filed: September 6, 2002
    Publication date: September 18, 2003
    Inventors: Samuel J. Danishefsky, Kaustav Biswas, Mark Chappell, Hong Lin, Jon T. Njardarson, Chul Bom Lee, Alexy Rivkin, Ting-Chao Chou
  • SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEREOF
    Publication number: 20100197746
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Application
    Filed: October 22, 2009
    Publication date: August 5, 2010
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEREOF
    Publication number: 20140213618
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Application
    Filed: August 20, 2013
    Publication date: July 31, 2014
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumihiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Patent number: 8110590
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: February 7, 2012
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of Epothilones, Intermediates Thereto, Analogues and Uses Thereof
    Publication number: 20090149516
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Application
    Filed: June 9, 2008
    Publication date: June 11, 2009
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Fumihiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong, Kaida Wu, Malcolm A.S. Moore, David Dorn
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Patent number: 6921769
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: July 26, 2005
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexy Rivkin, Fumikiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda
  • COMPOSITIONS AND METHODS FOR TREATING CANCER OR A NEUROTROPHIC DISORDER
    Publication number: 20110124690
    Abstract: The present invention relates to compositions comprising an effective amount of a Panaxytriol Compound and a tubulin-binding drug, methods for treating or preventing cancer or a neurotrophic disorder comprising administering to a subject in need thereof an effective amount of a Panaxytriol Compound and a tubulin-binding drug, and methods for making a Panaxytriol Compound.
    Type: Application
    Filed: February 22, 2008
    Publication date: May 26, 2011
    Inventors: Samuel J. Danishefsky, Heedong Yun, Ting-Chao Chou, Xiaoguang Lei, Dalibor Sames
  • SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF
    Publication number: 20100240721
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: May 28, 2010
    Publication date: September 23, 2010
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Publication number: 20040102495
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: October 28, 2003
    Publication date: May 27, 2004
    Inventors: Samual J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Patent number: 7649006
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: January 19, 2010
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Publication number: 20040019089
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: May 7, 2003
    Publication date: January 29, 2004
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Publication number: 20020002194
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: June 5, 2001
    Publication date: January 3, 2002
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Patent number: 7759374
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: July 20, 2010
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Fumikiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 7875638
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: January 25, 2011
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Fumihiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong, Kaida Wu, Malcolm A. S. Moore, David Dorn
  • SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF
    Publication number: 20110263663
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: March 3, 2011
    Publication date: October 27, 2011
    Applicant: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 8481575
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: July 9, 2013
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Publication number: 20030125362
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: March 14, 2001
    Publication date: July 3, 2003
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dong Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 6849651
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: February 1, 2005
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J Sorensen, Aaron Balog, Kenneth A Savin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: RE41990
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: December 7, 2010
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin