Search Patents
  • SOLID SALT FORMS OF A PYRROLE SUBSTITUTED 2-INDOLINONE
    Publication number: 20120142749
    Abstract: The present invention relates to solid salt forms of the 3-pyrrole substituted 2-indolinone compound 5-[5-fluoro-2-oxo-1, 2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pirrolidin-1-yl-ethyl)-amide. It also relates to polymorphs of the phosphate salt of the amide. The invention further relates to the use of the salts and polymorphs in the treatment of protein kinase related disorders.
    Type: Application
    Filed: February 6, 2012
    Publication date: June 7, 2012
    Applicants: PFIZER PRODUCTS INC., PFIZER INC.
    Inventors: Changquan C. Sun, Michael Hawley
  • Solid Salt Forms Of A Pyrrole Substituted 2-Indolinone
    Publication number: 20080275101
    Abstract: The present invention relates to solid salt forms of the 3-pyrrole substituted 2-indolinone compound 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide. It also relates to polymorphs of the phosphate salt of the amide. The invention further relates to the use of the salts and polymorphs in the treatment of protein kinase related disorders.
    Type: Application
    Filed: September 8, 2006
    Publication date: November 6, 2008
    Applicants: PFIZER INC., PFIZER PRODUCTS INC.
    Inventors: Michael Hawley, Changquan C. Sun
  • Acylaminoindole derivatives as 5-ht1 agonists
    Patent number: 5498626
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: March 12, 1996
    Assignee: Pfizer Inc.
    Inventor: John E. Macor
  • Indole derivatives useful as endothelin receptor antagonists
    Patent number: 6136843
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: October 24, 2000
    Assignee: Pfizer Inc
    Inventors: David James Rawson, Kevin Neil Dack, Roger Peter Dickinson, Kim James
  • Bicyclic carbamates and methods of treating inflammatory diseases using the same
    Patent number: 5280039
    Abstract: A compound of the formula ##STR1## wherein R is defined herein is useful as an anti-inflammatory agent.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: January 18, 1994
    Assignee: Pfizer Inc.
    Inventor: James F. Eggler
  • New process
    Publication number: 20030166704
    Abstract: The present invention provides an improved process for the preparation of the anti-migraine drug, (R)-5-(2-benzenesulphonylethyl)-3-N-methylpyrrolidin-2-ylmethyl)-1H-indole (eletriptan), available commercially as the hydrobromide salt, and an intermediate and dimer-free products obtained from such process.
    Type: Application
    Filed: November 13, 2001
    Publication date: September 4, 2003
    Applicant: Pfizer Inc.
    Inventor: Ronald James Ogilvie
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Publication number: 20030219489
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Application
    Filed: June 9, 2003
    Publication date: November 27, 2003
    Applicant: Pfizer Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Stable, long acting salts of carboxamides for the treatment of joint disease
    Patent number: 5968969
    Abstract: Calcium, magnesium, lidocaine and benzathine salts of 2-oxindole-1-carboxamides are useful for the treatment of joint disease by intra-articular administration.
    Type: Grant
    Filed: August 19, 1997
    Date of Patent: October 19, 1999
    Assignee: Pfizer Inc
    Inventor: Imran Ahmed
  • Glycogen phosphorylase inhibitor
    Publication number: 20030185891
    Abstract: Pharmaceutical compositions of a particularly effective sparingly soluble glycogen phosphorylase inhibitor are disclosed, as well as methods of making such compositions and dosage forms from such compositions.
    Type: Application
    Filed: March 21, 2003
    Publication date: October 2, 2003
    Applicant: Pfizer Inc.
    Inventors: Marshall D. Crew, Dwayne T. Friesen, Bruno C. Hancock, Chris Macri, James A.S. Nightingale, Ravi M. Shanker
  • Pharmaceutical compositions containing eletriptran hemisulphate and caffeine
    Patent number: 6166025
    Abstract: The present invention provides an aqueous pharmaceutical composition comprising 5 to 200 mg/ml of eletriptan hemisulfate and from 0.5 to 2.0% weight/volume of caffeine.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: December 26, 2000
    Assignee: Pfizer Inc.
    Inventors: Valerie Denise Harding, Anne Billotte
  • Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the treatment of cancer
    Publication number: 20030114503
    Abstract: The present invention relates to a method of treating cancer in a mammal, including a human, by administering to the mammal a FTase inhibitor in combination with an HMG CoA reductase inhibitor.
    Type: Application
    Filed: August 12, 2002
    Publication date: June 19, 2003
    Applicant: Pfizer Inc.
    Inventor: Shama Mohammed Kajiji
  • Cannabinoid receptor ligands and uses thereof
    Patent number: 7230024
    Abstract: Compounds of Formula (I) and (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: June 12, 2007
    Assignee: Pfizer Inc
    Inventors: Philip A. Carpino, Robert L. Dow
  • Substituted N-(indole-2-carbonyl) -amides and derivatives as glycogen phosphorylase inhibitors
    Publication number: 20040006088
    Abstract: 1
    Type: Application
    Filed: June 17, 2003
    Publication date: January 8, 2004
    Applicant: Pfizer Inc.
    Inventors: Dennis J. Hoover, Bernard Hulin, William H. Martin, Judith L. Treadway
  • Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors
    Patent number: 6297269
    Abstract: Compounds of the formula I: and their compositions are useful as glycogen phosphorylase inhibitors.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: October 2, 2001
    Assignee: Pfizer Inc.
    Inventors: Bernard Hulin, Dennis J. Hoover, Judith L. Treadway, William H. Martin
  • 3-AMINOCYCLOPENTANECARBOXAMIDES AS CHEMOKINE RECEPTOR AGONISTS
    Publication number: 20130197008
    Abstract: There is provided a compound of Formula I(a) or I(b): or a pharmaceutically acceptable salt thereof, wherein the various substitutents are defined herein.
    Type: Application
    Filed: September 14, 2012
    Publication date: August 1, 2013
    Applicant: Pfizer Inc.
    Inventors: Robert O. HUGHES, Rajesh V. Devraj, Donald J. Rogier, John I. Trujillo, Steve R. Turner, Wei Huang
  • Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents
    Patent number: 5607959
    Abstract: Compounds of formula (I) where R.sup.1 is thienyl, phenyl or furyl, X and Y are halogen or hydrogen and Q is alkoxy or amino are useful as analgesic and antiinflamatory agents.
    Type: Grant
    Filed: July 21, 1995
    Date of Patent: March 4, 1997
    Assignee: Pfizer Inc.
    Inventor: Ralph P. Robinson
  • 1,3-dicarboxamidooxindoles as analgesic and antiinflammatory agents
    Patent number: 4791129
    Abstract: 1,3,-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.
    Type: Grant
    Filed: November 9, 1987
    Date of Patent: December 13, 1988
    Assignee: Pfizer Inc.
    Inventor: Saul B. Kadin
  • Oxindole antiinflammatory agents
    Patent number: 4686224
    Abstract: Ketone containing 1-substituted oxindole-3-carboxamides as antiinflammatory agents prepared by reaction of the 1-substituted oxindole with an isocyanate or by aminolysis of the corresponding alkyl oxindole-3-carboxylate.
    Type: Grant
    Filed: August 6, 1985
    Date of Patent: August 11, 1987
    Assignee: Pfizer Inc.
    Inventor: Lawrence S. Melvin, Jr.
  • Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
    Patent number: 5116854
    Abstract: Certain 1-heteroaryl-3-acyl-2-oxindoles wherein the acyl-substituent is thenoyl, furoyl, benzoyl or substituted benzoyl, are inhibitors of cycloxygenase and lipoxygenase enzymes and are useful as anti-inflammatory agents in mammals.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: May 26, 1992
    Assignee: Pfizer Inc.
    Inventor: Anthony Marfat
  • 1,3-dicarboxamide-oxindoles as antiinflammatory agents
    Patent number: 4725616
    Abstract: 1,3-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.
    Type: Grant
    Filed: January 20, 1987
    Date of Patent: February 16, 1988
    Assignee: Pfizer Inc.
    Inventor: Saul B. Kadin