Search Patents
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Publication number: 20040053910
    Abstract: The present invention provides compounds of formula (I): 1
    Type: Application
    Filed: May 9, 2003
    Publication date: March 18, 2004
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Publication number: 20030176368
    Abstract: The present invention provides compounds of formula (I): 1
    Type: Application
    Filed: September 6, 2002
    Publication date: September 18, 2003
    Inventors: Samuel J. Danishefsky, Kaustav Biswas, Mark Chappell, Hong Lin, Jon T. Njardarson, Chul Bom Lee, Alexy Rivkin, Ting-Chao Chou
  • Novel Macrocycles and Uses Thereof
    Publication number: 20080108694
    Abstract: The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) wherein Ro-R4, Z, X, A-B, D-E, G-J, and K-L are as defined herein, the synthesis thereof and the use of these compounds as therapeutic agents.
    Type: Application
    Filed: December 17, 2004
    Publication date: May 8, 2008
    Inventors: Samuel J Danishefsky, Zhi-Qiang Yang, Xudong Geng, Ting-Chao Chou, Neal Rosen
  • SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEREOF
    Publication number: 20140213618
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Application
    Filed: August 20, 2013
    Publication date: July 31, 2014
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumihiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Patent number: 6921769
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: July 26, 2005
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexy Rivkin, Fumikiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Patent number: 7649006
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: January 19, 2010
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Publication number: 20030125362
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: March 14, 2001
    Publication date: July 3, 2003
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dong Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Publication number: 20030069277
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.
    Type: Application
    Filed: April 30, 2002
    Publication date: April 10, 2003
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin, Scott Kuduk, Christina Harris, Xiu-Guo Zhang, Joseph R. Bertino
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 6242469
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: June 5, 2001
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 6828340
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: December 7, 2004
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J Sorensen, Aaron Balog, Kenneth A. Savin