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  • Oxygenated alkyl substituted bicyclo alkanes
    Patent number: 4689345
    Abstract: Anti-androgenic composition compound of the formula ##STR1## wherein Q is CO, CH(OR), CR(OH), or CR (OC)-lower alkyl);R is H, or C.sup.1-2 -alkyl;X is hydroxyalkyl, methoxy-C.sup.2-11 -alkyl, ethoxy-C.sup.2-11 -alkyl or oxo-C.sup.2-11 -alkyl, formyl-C.sup.2-11 -alkyl, carboxy-C.sup.2-11 -alkyl or (C.sub.1-2 -alkyl) oxycarbonyl-C.sup.2-11 -alkyl;c is 1 or 2;p or w are 0, 1 or 2 and the sum of p and w is 1 to 4;and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: August 25, 1987
    Assignee: CBD Corporation
    Inventors: Walter J. Kasha, Chantal S. Burnison
  • Oxygenated alkyl substituted bicyclo alkanes
    Patent number: 4855322
    Abstract: A compound of the formula ##STR1## wherein Q is CO, CH(OR), CR(OH), or CR (OC)-lower alkyl); R is H, or C.sup.1-2 -alkyl;X is hydroxyalkyl,methoxy-C.sup.2-11 -alkyl, ethoxy-C.sup.2-11 -alkyl or oxo-C.sup.2-11 -alkyl, formyl-C.sup.2-11 -alkyl,carboxy-C.sup.2-11 -alkyl or (C.sub.1-2 -alkyl) oxycarbonyl-C.sup.2-11 -alkyl;c is 1 or 2;p or w are 0, 1 or 2 and the sum of p and w is 1 to 4;and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 1, 1987
    Date of Patent: August 8, 1989
    Assignee: CBD Corporation
    Inventors: Walter J. Kasha, Chantal S. Burnison
  • Anti-tumor halo bicyclo alkanones
    Patent number: 4689349
    Abstract: Potent tumor inhibitors are prepared which are compounds of the formula: ##STR1## wherein Q is CO, CH(OH) or C(OH)CH.sub.3,M.sub.1 is halogen,M.sub.2 is halogen or hydrogen,c is one or twop is 0 or 1, andone of X and X' is H and the other is hydroxy-C.sup.2-9 alkyl, methoxy-C.sup.2-9 -alkyl, ethoxy-C.sup.2-9 -alkyl, oxo-C.sup.2-9 -alkyl, formyl-C.sup.2-9 -alkyl, carboxy-C.sup.2-9 -alkyl or (C.sub.1-2 -alkyl)oxycarbonyl-C.sup.2-9 -alkyl.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: August 25, 1987
    Assignee: CBD Corporation
    Inventors: Walter J. Kasha, Chantal S. Burnison