Abstract: The invention relates to the spike protein from the virus (SARS-CoV) that is etiologically linked to severe acute respiratory syndrome (SARS); polypeptides and peptide fragments of the spike protein; nucleic acid segments and constructs that encode the spike protein, polypeptides and peptide fragments of the spike protein, and coupled proteins that include the spike protein or a portion thereof; peptidomimetics; vaccines; methods for vaccination and treatment of severe acute respiratory syndrome; antibodies; aptamers; and kits containing immunological compositions, or antibodies (or aptamers) that bind to the spike protein.
Type:
Application
Filed:
January 19, 2007
Publication date:
December 10, 2009
Inventors:
Dimiter S. Dimitrov, Xiaodong Xiao, Zhu Zhongyu
Abstract: The subject invention relates in part to novel uses of bacteriophage tail spike proteins (TSPs). Some preferred uses are therapeutic uses in animals, such as chickens, against pathogenic bacteria, such as Salmonella. Fragments of the TSPs can also be used according to the subject invention, particularly protein fragments comprising the phage receptor binding domains (PRBDs), which recognize their hosts and facilitate infection. The binding domains are specific to unique surface structures on bacteria and may be used for a variety of applications according to the subject invention. We have shown that by utilizing these PRBDs, it is possible to exploit the long-established evolutionary relationship between bacteria and their viruses (ie bacteriophages) that specifically infect them. The subject invention also relates in part to novel, synthetic forms of tail spike proteins. In some preferred embodiments, these are hexamers.
Type:
Application
Filed:
March 28, 2008
Publication date:
June 16, 2011
Applicants:
Dow AgroSciences LLC, National Research Council of Canada
Inventors:
Matthew J. Henry, Roger C. Mackenzie, Christine Szymanski, Jamshid Tanha
Abstract: The present invention relates to a novel tail spike protein (TSP) encoded by the novel Listeria bacteriophage designated ProCC P825 and uses of the novel TSP for identifying, detecting and monitoring of Listeria.
Type:
Application
Filed:
May 29, 2012
Publication date:
October 9, 2014
Applicant:
BIOMERIEUX SA
Inventors:
Holger Grallert, Sonja Molinaro, Julia Lorenz
Abstract: The invention provides methods and means for distinguishing FECV and FIPV, and methods and means for determining whether FIPV is present in a sample. Further provided are primers and probes for detecting FIPV specific nucleic acid sequences encoding a spike protein, antibodies for detecting a FIPV, and an immunogenic composition and use thereof for eliciting an immune response against a feline coronavirus, preferably a FIPV.
Type:
Application
Filed:
January 18, 2011
Publication date:
March 21, 2013
Applicant:
Universiteit Utrecht Holding B.V.
Inventors:
Petrus Josephus Marie Rottier, Hui-Wen Chang, Herman F. Egberink
Abstract: A canine respiratory coronavirus (CRCV) that is present in the respiratory tract of dogs with canine infectious respiratory disease and which has a low level of homology to the enteric canine coronavirus, but which has a high level of homology to all bovine coronavirus strains (e.g., Quebec and LY138) and human coronavirus strain OC43.
Type:
Application
Filed:
September 26, 2008
Publication date:
March 26, 2009
Applicant:
The Royal Veterinary College
Inventors:
John Brownlie, Victoria Jane Chalker, Kerstin Erles