Abstract: The invention provides monoclonal antibodies to human cytochrome P450 2C8, 2C9, 2C18, and 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of the various human cytochrome P450 2C family members and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C family members, and in methods of screening individuals for a poor metabolizing individual human P450 2C family phenotypes.
Type:
Grant
Filed:
December 22, 1999
Date of Patent:
September 23, 2003
Assignee:
The United States of America as represented by the Department
of Health and Human Services
Inventors:
Harry V. Gelboin, Kristopher W. Krausz, Frank J. Gonzalez
Abstract: The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2A6 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2A6 and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2A6, and in methods of measuring p450 2A6 levels in an individual relative to p450 2A6 levels in a control population.
Type:
Grant
Filed:
April 8, 1999
Date of Patent:
November 27, 2001
Assignee:
The United States of America as represented by the Department
of Health and Human Services
Abstract: The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 1A2 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 1A2 and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 1A2, and in methods of measuring p450 1A2 levels in individuals relative to p450 1A2 levels in a control population.
Type:
Grant
Filed:
April 8, 1999
Date of Patent:
January 1, 2002
Assignee:
The United States of America as represented by the Department
of Health and Human Services
Inventors:
Harry V. Gelboin, Frank J. Gonzalez, Tian J. Yang