Abstract: The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2C19 and lack of specific binding to other human cytochrome P450s. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C19, and in methods of measuring P450 2C 19 levels in individuals relative to P450 2C19 levels in a control population.
Type:
Application
Filed:
September 10, 2001
Publication date:
August 22, 2002
Inventors:
Harry V. Gelboin, Kristopher W. Krausz, Frank J. Gonzalez
Abstract: The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 1A2 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 1A2 and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 1A2, and in methods of measuring p450 1A2 levels in individuals relative to p450 1A2 levels in a control population.
Type:
Grant
Filed:
April 8, 1999
Date of Patent:
January 1, 2002
Assignee:
The United States of America as represented by the Department
of Health and Human Services
Inventors:
Harry V. Gelboin, Frank J. Gonzalez, Tian J. Yang
Abstract: The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2A6 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2A6 and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2A6, and in methods of measuring p450 2A6 levels in an individual relative to p450 2A6 levels in a control population.
Type:
Grant
Filed:
April 8, 1999
Date of Patent:
November 27, 2001
Assignee:
The United States of America as represented by the Department
of Health and Human Services
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