Search Patents
  • 4,4-Biarylpiperidine derivatives
    Publication number: 20040138220
    Abstract: The present invention relates to compounds of the formula I, 1
    Type: Application
    Filed: December 23, 2003
    Publication date: July 15, 2004
    Applicants: Pfizer, Inc., Pfizer Products, Inc.
    Inventor: Spiros Liras
  • Pyridazinone aldose reductase inhibitors
    Patent number: 7572910
    Abstract: The present invention relates to novel pyridazinone compounds, pharmaceutical compositions comprising those compounds and to methods of using such compounds and compositions to inhibit aldose reductase, lower sorbitol levels and, thus, lower fructose levels, and/or treat or prevent diabetic complications such as diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, diabetic cardiomyopathy, diabetic microangiopathy and diabetic macroangiopathy in mammals. This invention also relates to methods of affording cardioprotection to subjects not suffering from diabetes. This invention also relates to pharmaceutical compositions and kits comprising a combination of an aldose reductase inhibitor (ARI) of this invention and a sorbitol dehydrogenase inhibitor and to methods of using such compositions or kits to treat or prevent the above diabetic complications in mammals.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: August 11, 2009
    Assignee: Pfizer, Inc.
    Inventor: Banavara L. Mylari
  • Benzimidazole cyclooxygenase-2 inhibitor
    Publication number: 20040181062
    Abstract: This invention provides a compound of the following formula: 1
    Type: Application
    Filed: February 5, 2004
    Publication date: September 16, 2004
    Applicant: Pfizer Inc
    Inventors: Yoshiyuki Okumura, Yoshinori Murata, Takashi Mano
  • Processes for the preparation of substituted bicyclic derivatives for the treatment of abnormal cell growth
    Publication number: 20030144506
    Abstract: The invention relates to processes for preparing compounds of the formula 1 1
    Type: Application
    Filed: December 2, 2002
    Publication date: July 31, 2003
    Applicant: Pfizer Inc.
    Inventor: David Harold Brown
  • 5HT7 Antagonists and inverse agonists
    Publication number: 20040229874
    Abstract: The present invention relates to compounds of formula I, 1
    Type: Application
    Filed: January 27, 2004
    Publication date: November 18, 2004
    Applicant: Pfizer Inc.
    Inventors: Gene Michael Bright, Karen J. Coffman
  • Diazabicyclic compounds useful in the treatment of CNS and other disorders
    Publication number: 20040106603
    Abstract: The present invention relates to a compounds of formula I: 1
    Type: Application
    Filed: September 8, 2003
    Publication date: June 3, 2004
    Applicant: Pfizer Inc
    Inventors: Jotham W. Coe, Christopher J. O'Donnell, Brian T. O'Neill, Lawrence A. Vincent
  • Selective inhibitors of cyclooxygenase-2
    Publication number: 20030207897
    Abstract: The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I: 1
    Type: Application
    Filed: April 16, 2003
    Publication date: November 6, 2003
    Applicant: Pfizer Inc.
    Inventors: Kristin Lundy DeMello, Brian S. Bronk, Rhonda Marie Crosson
  • Beta3 adrenergic receptor agonists and uses thereof
    Publication number: 20030203913
    Abstract: The instant invention provides &bgr;3 adrenergic receptor agonists of structural Formula (I), 1
    Type: Application
    Filed: March 5, 2003
    Publication date: October 30, 2003
    Applicant: Pfizer Inc.
    Inventors: Robert F. Day, Jennifer A. Lafontaine
  • 3-Benzhydrylidene-8-aza-bicyclo[3.2.1]octane derivatives with opioid receptor activity
    Publication number: 20040254190
    Abstract: The present invention relates to compounds of the formula I, 1
    Type: Application
    Filed: April 14, 2004
    Publication date: December 16, 2004
    Applicant: Pfizer Inc
    Inventor: Spiros Liras
  • Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents
    Publication number: 20030144280
    Abstract: This invention relates to a compound of the formula: 1
    Type: Application
    Filed: December 31, 2002
    Publication date: July 31, 2003
    Applicant: PFIZER INC.
    Inventors: Kazuo Ando, Kiyoshi Kawamura
  • Phenyl heterocyclyl ethers
    Publication number: 20040106594
    Abstract: The invention relates to compounds of formula I 1
    Type: Application
    Filed: November 25, 2003
    Publication date: June 3, 2004
    Applicant: Pfizer Inc
    Inventors: Mavis D. Adam, Mark D. Andrews, Geoffrey E. Gymer, David Hepworth, Harry R. Howard, Donald S. Middleton, Alan Stobie
  • Positive allosteric modulators of the nicotinic acetylcholine receptor
    Publication number: 20040249150
    Abstract: The invention provides compounds of Formula I: 1
    Type: Application
    Filed: June 29, 2004
    Publication date: December 9, 2004
    Applicant: Pfizer Inc
    Inventors: David W. Piotrowski, Bruce N. Rogers, William W. McWhorter, Daniel Patrick Walker, Jeffrey W. Corbett, Vincent E. Groppi, Daniel G. Rudmann
  • Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents
    Publication number: 20030236258
    Abstract: The present invention relates to compounds of the formula 1
    Type: Application
    Filed: January 14, 2003
    Publication date: December 25, 2003
    Applicant: Pfizer Inc.
    Inventors: Kristin M. Lundy, Hengmiao Cheng, Subas M. Sakya, Jin Li, Martha L. Minich, Chikara Uchida
  • 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine D4 receptor
    Publication number: 20030100757
    Abstract: A compound of the formula 1
    Type: Application
    Filed: January 10, 2003
    Publication date: May 29, 2003
    Applicant: Pfizer Inc.
    Inventors: Anton Franz Josef Fliri, Mark Jerome Majchrzak, Patricia Ann Seymour, Steven Howard Zorn, Hans Rollema
  • Positive allosteric modulators of the nicotinic acetylcholine receptor
    Publication number: 20040254373
    Abstract: The invention provides compounds of Formula I: 1
    Type: Application
    Filed: June 30, 2004
    Publication date: December 16, 2004
    Applicant: Pfizer Inc
    Inventors: David W. Piotrowski, Bruce N. Rogers, William W. McWhorter, Daniel Patrick Walker, Jeffrey W. Corbett, Vincent E. Groppi, Daniel G. Rudmann
  • Hydrazinyl and nitrogen oxide pyrazoles
    Publication number: 20030134850
    Abstract: The present invention relates to hydrazinyl and nitrogen oxide pyrazoles of the formula I: 1
    Type: Application
    Filed: November 1, 2002
    Publication date: July 17, 2003
    Applicant: Pfizer Inc.
    Inventors: Subas M. Sakya, Bryson Rast
  • Substituted N-(indole-2-carbonyl) -amides and derivatives as glycogen phosphorylase inhibitors
    Publication number: 20040006088
    Abstract: 1
    Type: Application
    Filed: June 17, 2003
    Publication date: January 8, 2004
    Applicant: Pfizer Inc.
    Inventors: Dennis J. Hoover, Bernard Hulin, William H. Martin, Judith L. Treadway
  • Compounds as casein kinase inhibitors
    Patent number: 8518944
    Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: August 27, 2013
    Assignee: Pfizer Inc.
    Inventors: Chakrapani Subramanyam, Travis T. Wager
  • Bicyclo-pyrazoles
    Patent number: 7541354
    Abstract: Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: June 2, 2009
    Assignee: Pfizer Italia S.r.l.
    Inventors: Daniele Fancelli, Valeria Pittala, Mario Varasi
  • 3-aminocyclopentanecarboxamides as chemokine receptor agonists
    Patent number: 8946413
    Abstract: There is provided a compound of Formula I(a) or I(b): or a pharmaceutically acceptable salt thereof, wherein the various substitutents are defined herein.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: February 3, 2015
    Assignee: Pfizer Inc.
    Inventors: Robert O. Hughes, Rajesh V. Devraj, Donald J. Rogier, John I. Trujillo, Steve R. Turner, Wei Huang