Abstract: Automated systems and methods for withdrawing a selected compound from blood are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further combines the separated component with a solvent so as to remove a compound from the blood component.

Abstract: A hemodialysis system including (i) an instrument; (ii) first and second peristaltic dialysate pumps operated by the instrument; (iii) a cassette including a rigid structure and first and second dialysate pumping tubes carried by the rigid structure; and (iv) a mechanism configured to initially allow the cassette to be accepted by the dialysis instrument after which the mechanism engages the first and second dialysate pumping tubes for operation with the first and second peristaltic dialysate pumps.

Abstract: Apparatuses, devices, systems and methods for detecting access disconnection are provided. In one embodiment, a medical fluid system includes (i) a medical fluid machine and (ii) a device operable with the medical fluid machine, the device configured to provide electrical contact with a medical fluid, the device including (a) a tube used during dialysis therapy through which the medical fluid can flow, and (b) a conductive element configured to self-sealingly pierce the tube, the conductive element having a first portion exposed to the medical fluid and a second portion external to the tube.

Abstract: Systems and methods separate platelets from a selected donor. The systems and methods convey anticoagulated blood containing plasma and platelets from the selected donor into the separation device for separating into a plasma yield and a platelet yield. The systems and methods estimate, at least in part while separation occurs, a count of platelets (PltCirc) available for collection from the selected donor by measuring the selected donor's platelet precount (Pltpre), estimating a dilution factor caused by addition of anticoagulant (Dilution), and estimating a depletion factor (Depletion) caused by removal of available platelets during blood processing. In estimating Depletion, the systems and methods take into account a splenic mobilization function (Spleen), which is derived from a population of donors and not specific to the selected donor, where Spleen comprises a function of PltPRE.

Abstract: A kidney failure therapy system includes: (a) a dilaysate supply; (b) at least one valve actuator; (c) at least one pump actuator; and (d) a disposable unit including first and second flexible sheets sealed together for form: (i) at least one flow path configured to be placed in fluid communication with the dilaysate supply; and operable with the at least one valve actuator; and (ii) at least one pumping portion configured to operate with the at least one pump actuator.

Abstract: An access disconnection system includes: a material capable of absorbing blood from a patient upon an arterial or venous line disconnection; a light emitter positioned to emit light onto the material; a light receiver positioned to receive light reflected off of the material; and electronic circuitry operably coupled to at least one of the light emitter and receiver, the circuitry configured to provide an output (i) when light received by the receiver reaches a particular level or (ii) indicative of an amount of light received by the light receiver.

Abstract: A dialysis system includes: a water purification unit; a dialysate generation unit configured to use water purified by the water purification unit; a dialysate delivery unit configured to deliver dialysate prepared by the dialysate generation unit; a supplemental power source; and electronic circuitry including: (i) a first electrical connection configured to electrically connect a branch power source with at least one of the water purification unit, the dialysate generation unit and the dialysate delivery unit, and (ii) a second electrical connection configured to electrically connect a supplemental power source with at least one of the water purification unit, the dialysate generation unit and the dialysate delivery unit.