Abstract: A biochemical implant is described which comprises at least two matrix components. The first matrix component is composed of collagen with a porous macrostructure with the ability to withstand tensile or shear forces. The second matrix component is a hydrated alginate gel which substantially fills the porous macrostructure of the first component and exerts a swelling pressure. The implant additionally comprises a population of cells comprising chondrocytes, fibrochondrocytes, fibroblasts or osteoblasts, or precursors thereof.
January 29, 2001
August 23, 2001
David A. Lee, Daniel L. Bader, Myra D. Stephens