Abstract: By treating potable water at a temperature of at least 230° C. (446° C.) and at a pressure at least equal to the pressure of saturated steam at said temperature, can produce pyrogen-free water using treatment times of 0.05 to 5 seconds or less. The addition of an oxidant, in the form of a gas, a liquid, or a solid, further decreases the required treatment time to less than 0.05 second. The reduction in equipment size achieved with this rapid treatment time allows the utilization of treatment units small enough to be easily transported to remote locations or installed in the restricted space environment existing in ships and submarines.
Abstract: The present invention provides a new and improved system for on-site and on-demand production of sterile water for injection (SWFI) from potable water or water that meets the EPA drinking water quality upon preconditioning, in conjunction with reconstitution of IV fluids using dry chemicals or concentrate pre-filled bags, suitable for use at a site under non-clean room environment conditions, and capable of adjusting feed water temperatures. The present invention includes a water temperature conditioning module, a water preconditioning module, a hydrothermal processor, a fluid staging compartment, and combinations and variations thereof.
Abstract: A fluid processor, suitable for the production of sterile water for injection, having a processor assembly and a process control system comprising a pump, a flow splitter, flow restrictors and a pressure relief valve. In a preferred embodiment, the processor assembly comprises a heat exchanger, a reactor and a heater arranged in a nested configuration. The preferred embodiment of the present invention also include a treatment assembly having a combination of filter, reverse osmosis and ion exchange devices and further incorporates an assembly and method allowing for the in situ sanitization of the fluid processor during cold start and shutdown to prevent bacteria growth during storage of the fluid processor. The fluid processor may include an electronic control system comprising a touch screen operator interface, a programmable logic controller and sensors for measuring temperature, pressure, flow rate, conductivity and endotoxin level.
Type:
Grant
Filed:
July 11, 2003
Date of Patent:
October 17, 2006
Assignee:
Applied Research Associates, Inc.
Inventors:
Lixiong Li, Timothy J. Campbell, Robert K. Nichols, Jr., Kristopher S. Cozart