Abstract: 13-Chloro-octahydrobanzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-5 -ols, substituted on the piperidine ring with lower alkyl or a cycloalkyl are disclosed. The compounds are useful CNS depressants. Methods for their preparation and use also are disclosed.

Abstract: Novel compositions comprising wetted mixtures of poorly soluble drugs with water soluble polymers useful in increasing bioavailability are disclosed.

Abstract: Herein is described a filtering unit for biological fluids. The filtering unit is composed of an open top container, a cover for the container, a filter which is in contact with the cover and extends downwardly into the container and an aperture in the cover through which the filtered fluid is withdrawn. The filtering unit provides a sample of the filtered fluid using an inexpensive apparatus and can be used by unskilled operators.

Abstract: Herein is described a method of treating benign prostatic hyperlasia without affecting testicular weight in a male mammal by administering an effective amount of gonadorelin.

Abstract: This invention relates to immunologic compositions comprising pyruvic aldehyde stabilized erythrocytes sensitized with an antigen by coupling of the stabilized erythrocytes to the antigen with bifunctional molecules, and to methods for preparing these compositions. Also disclosed are antiserum compositions which may be utilized with the described stable, sensitized erythrocytes of this invention as reagents in hemagglutination tests, and methods for their preparation. The invention further comprises lyophilization of these compositions and siliconized vials for use with the reagents of this invention.

Abstract: Novel sustained release compositions comprising a core containing a drug, a seal coating surrounding the core and a sugar coating surround the seal coated core are disclosed.

Abstract: Novel sustained release compositions comprising a core containing a drug, a seal coating surrounding the core and a sugar coating surround the seal coated core are disclosed.

Abstract: Disclosed are new methods of using (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3- acetic acid or a therapeutically acceptable salt thereof with an organic or inorganic base for the treatment of complications associated with diabetes mellitus. The compound inhibits lens aldose reductase in a diabetic mammal.

Abstract: A novel method of treating aphthous stomatitis, lesions, sores and blisters affecting the mucous membranes and surrounding areas comprising topical application of tape dosage forms containing minor amounts of topically effective active ingredients is disclosed.

Abstract: An improved method for measuring and dispensing fractions of a liquid sample in a device which comprises a casing having a vertical axis and containing a central chamber and transparent cells distributed around the chamber. Each cell is connected to the chamber by a closure cup. A capillary constriction separates each pocket from the corresponding cell. The improvement comprises adding polyvinylpyrollidone to the liquid sample.

Abstract: A mixture of at least two liquid compositions, each having a material which is incompatible in the presence of moisture with a material in the other liquid composition, is cooled to a temperature slightly above its freezing point. The cooled mixture is charged into a container cooled substantially below the freezing point of the mixture so the mixture freezes instantly. The frozen mixture is lyophilized to provide a mass of dry matter.

Abstract: Herein is described a process for oxidizing 1,2-diphenyl-4-[2-(phenylthio)ethyl]-3,5-pyrazolidinedione with peroxymonosulfuric acid to obtain 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione.

Abstract: Novel sustained release compositions comprising a core containing a drug, a seal coating surrounding the core and a sugar coating surrounding the seal coated core are disclosed.

Abstract: Novel sustained release compositions comprising a core containing a drug, a seal coating surrounding the core and a sugar coating surround the seal coated core are disclosed.

Abstract: Novel sustained release compositions comprising a core containing a drug, a seal coating surrounding the core and a sugar coating surround the seal coated core are disclosed.

Abstract: A simple, sensitive, reliable and safe method and device for detecting a polypeptide or glycoprotein antigen. The test involves concentration in the presence of polyvinylpyrrolidone by ultrafiltration of a sample of urine or serum from a subject; followed by determining the presence of said polypeptide or glycoprotein antigen or a particular subunit thereof in the concentrated sample.

Abstract: This invention is directed to novel compounds having .beta.-adrenergic blocking activity. The compounds are represented by the following structural formula: ##STR1## wherein R.sup.1 is hydrogen or methyl, R.sup.2 is hydrogen or lower alkyl and their pharmaceutically acceptable salts.

Abstract: Furo[3,4-b]quinoline derivatives, having both an alkyl substituent and an alkyl or alkylene amide substituent at position 3 are disclosed. The derivatives can be further substituted at positions 1 and 9. The furo[3,4-b]quinoline derivatives of this invention are useful antihypertensive and antimicrobial agents. Methods for the preparation and use of these derivatives are also disclosed.