Abstract: Compounds of Formula (I) are effective in the treatment of a microbial infection.

Abstract: HPTPbeta is useful as a target in screening agents effective for the treatment of angiogenesis mediated disorders.

Abstract: Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy.

Abstract: Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy.

Abstract: A child safety restraining device comprising: (a) one ankle strap having a first end and a second end; (b) means for fastening the first end and the second end of the ankle strap to each other; (c) one anchor strap having a first end and a second end; (d) means for attaching the first end of the anchor strap and the ankle strap to each other; and (e) means for anchoring the second end of the anchor strap to an apparatus, e.g. a shopping cart, in which a child may be seated, at an anchoring point on the apparatus. Also provided are methods of using such a device to restrain seated children and increase their safety.

Abstract: A child safety restraining device comprising: (a) an ankle strap having a first end and a second end; (b) means for fastening the first end and the second end of the ankle strap to each other; (c) an anchor strap having a first end and a second end; (d) means for attaching the first end of the anchor strap and the ankle strap to each other; and (e) means for anchoring the second end of the anchor strap to an apparatus, e.g. a shopping cart, in which a child may be seated, at an anchoring point on the apparatus. Also provided are methods of using such a device to restrain seated children and increase their safety.

Abstract: The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) 1:2, poly(methacrylic acid, methyl methacrylate) 1:1, and mixtures thereof; and c. an outer coating layer comprising an enteric polymer or film coating material; wherein the inner coating layer is not the same as the outer coating layer; wherein if the inner coating layer is poly(methacrylic acid, methyl methacrylate) 1:1 then the outer coating layer is not poly(methacrylic acid, methyl methacrylate) 1:2 or is not a mixture of poly(methacrylic acid, methyl methacrylate) 1:1 and poly(methacrylic acid, methyl methacrylate) 1:2; and wherein the inner coating layer and the outer coating layer do not contain any therapeutically active agent.

Abstract: The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I). Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

Abstract: Compounds having the general structure which are effective antimicrobial agents.

Abstract: Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where J, M, Q, T, W, X, Z, R1, R2, R3, R4, R4′, R5, R6, R6′, R7, m, and n have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also disclosed are pharmaceutical compositions comprising these compounds, and methods of treating or preventing metalloprotease-related maladies using the compounds or the pharmaceutical compositions.

Abstract: This invention relates to a topical composition for treating amino acid based substrates comprising a protected nucleophilic compound having the formula R—(Nu—Pr)m where R is a functional group, Nu is a nucleophile, and Pr is a phosphorus-containing protecting group, and m is an integer between 1 and 6. The invention further relates to systems which comprise this protected nucleophilic compound and an activating mechanism. The protected nucleophilic compounds of the present invention may be used in hair care compositions, textile care compositions, laundry care compositions, deodorant compositions, skin care compositions, cosmetic compositions, oral care compositions, and animal care compositions.

Abstract: Disclosed are shampoo compositions that provide a superior combination of anti-dandruff efficacy and conditioning, and a method of cleansing and conditioning the hair comprising applying to the hair an effective amount of said compositions. The anti-dandruff and conditioning shampoos comprise: (A) from about 5% to about 50%, by weight of the composition, of an anionic surfactant; (B) from about 0.01% to about 10%, by weight of the composition, of a non-volatile conditioning agent; (C) from about 0.1% to about 4%, by weight of the composition, of an anti-dandruff particulate; (D) from about 0.02% to about 5%, by weight of the composition, of a cationic guar derivative; (i) wherein said cationic guar derivative has a molecular weight from about 50,000 to about 700,000; and (ii) wherein said cationic guar derivative has a charge density from about 0.05 meq/g to about 1.0 meq/g; and (E) water.

Abstract: According to the present invention there is provided a personal cleansing composition comprising an anionic and/or amphoteric surfactant and a polymeric ester comprising: (i) a polyol; (ii) a monocarboxylic acid having from 4 to 30 carbon atoms; and (iii) a dicarboxylic acid. The compositions of the present invention provide improved in-use sensory feel while at the same time being exceptionally mild to the skin.

Abstract: Disclosed is an isolated polypeptide comprising an amino acid sequence substantially as shown in SEQ ID NO:2, or substantially similar to an amino acid sequence encoded by a nucleotide sequence in a plasmid having all the identifying characteristics of Deposit No. FERM BP-6129. Also disclosed is an isolated polynucleotide substantially as shown in SEQ ID NO:1, or substantially similar to a nucleotide sequence contained in a plasmid having all of the identifying characteristics of Deposit No. FERM BP-6129. Further disclosed is an expression system comprising the above polynucleotide. Further disclosed is a composition comprising the above polypeptide.

Abstract: This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr)m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. A preferred embodiment of the present invention provides a silicone composition and method for making. The composition comprises a polysiloxane or silicone resin, at least one linker, and at least one molecular hook.

Abstract: An alkaline hair bleaching composition comprising (a) from about 0.01% to about 12%, by weight, of at least one oxidizing agent; (b) from about 0.2% to about 20%, by weight, of a buffering system, present in an amount sufficient to generate a pH of the composition in the range from about 5 to about 11, wherein said buffering system comprises at least one pH modifying ingredient selected from the group consisting of (i) borates buffers, (ii) alkalizing agents, and mixtures thereof; (c) from about 150 ppm to about 5,000 ppm of at least one stabilizer; and (d) from about 0.01% to about 50%, by weight, of at least one hair care ingredient selected from the group consisting of (i) surfactants, (ii) catalysts, (iii) thickeners, (iv) conditioners, and mixtures thereof.

Abstract: An applicator system, for use in delivering a flowable composition, comprising; (a) container including an inner collapsible layer distinct from an outer deformable layer, the inner collapsible layer defining a reservoir, and the outer deformable layer being separated from the inner collapsible layer by a buffer zone; (b) a dispenser including a first passageway distinct from a second passageway, the first passageway being in communication with the buffer zone and the second passageway being in communication with the reservoir; and (c) valve means operable to control entry of air into the buffer zone through the first passageway and exit of flowable composition from the reservoir through the second passageway; wherein the valve means is of unitary construction.

Abstract: This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr)m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. Preferred embodiments of the present invention provide a modified UV absorber and a modified antioxidant, methods for making them and compositions conprising them.

Abstract: Disclosed is a hair conditioning composition comprising. (1) a high molecular weight ester oil being water-insoluble, having a molecular weight of at least about 800, and in liquid form at 25° C., the high molecular weight ester oil selected from the group consisting of: a) pentaerythritol ester oils, b) trimethylol ester oils, and mixtures thereof; (2) a hydrophilically substituted cationic surfactant; (3) a high melting point compound having a melting point of at least 25° C.; and (4) an aqueous carrier.

Abstract: An applicator assembly for applying liquid product to the hair. The applicator assembly has an applicator that further base and multiple tines extending from the base. Opposite the tines, the base has a liquid distribution cavity. At least some of the tines have a tip at the end opposite the base, and may also have an enlarged fin section adjacent to the base. The enlarged fin sections extends to a shoulder portion located less than half way upward between the base and the tip of the tine. The tines may also have an aperature that allows fluid to be distributed from the cavity directly to the hair. The tip of the tine may be relatively flexible, while its enlarged fin section provides a more rigid lower portion.