Patents Represented by Attorney Beverly K. Johnson
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Patent number: 5281618Abstract: Storage stable pesticide compositions comprising neem seed extracts which contain azadirachtin as the active pesticidal ingredient wherein the compositions are characterized by their non-degrading solvent systems and high concentrations, i.e., greater than 10 g/l, of azadirachtin. In one embodiment, the pesticide compositions contain solvent systems characterized as having greater than 50% by volume aprotic solvents and less than 15% by volume water. In a second embodiment, the pesticide compositions contain solvent systems characterized as having greater than 50% by volume alcohol and less than 5% by volume water.Type: GrantFiled: September 21, 1992Date of Patent: January 25, 1994Assignee: W. R. Grace & Co.-Conn.Inventor: James F. Walter
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Patent number: 5238545Abstract: An electrophoretic gel comprising at least one crosslinked temperature-responsive polymeric compound having an LCST is disclosed. A method of separating and recovering substances involves conducting the electrophoresis of a sample containing substances to be separated using the electrophoretic gel at a temperature below the LCST, excising each portion of the gel containing the substance to be separated and raising the temperature of the excised portion to a temperature above the LCST to shrink the excised portion to recover the substances.Type: GrantFiled: January 19, 1993Date of Patent: August 24, 1993Assignee: W. R. Grace & Co.-Conn.Inventors: Hiroshi Yoshioka, Yuichi Mori
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Patent number: 5232848Abstract: This defined basal nutrient medium is very effective in both high and low density culture of a wide variety of cell lines and cell types. The medium may be used for serum-free culture or supplemented with low levels of serum. The medium contains a buffer system formulated for air equilibration.Type: GrantFiled: November 16, 1989Date of Patent: August 3, 1993Assignee: W. R. Grace & Co.-Conn.Inventors: Richard A. Wolfe, Aaron H. Heifetz, Linda M. Custer
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Patent number: 5232815Abstract: A coating of resin and photoactive functionality is autodeposited from an emulsion onto a metallic substrate in order to selectively protect the substrate from corrosive environments such as etchant processes. An acid and oxidizing agent are included in the emulsion so that when the substrate is immersed in the emulsion the resin and photoactive functionality autodeposits. The resulting coating can be exposed to actinic radiation in an image-wise fashion and developed in an alkaline solution to develop the image created. In instances where the emulsion and process are used to make circuit boards, the metallic surface uncovered during developing is then etched away, leaving only the coated sections of the surface. The resulting coated surfaces will be the circuit traces of the circuit board.Type: GrantFiled: April 20, 1992Date of Patent: August 3, 1993Assignee: W. R. Grace & Co.-Conn.Inventors: Alan R. Browne, Daniel J. Hart, Alan F. Becknell, Betsy Elzufon
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Patent number: 5225062Abstract: An electrophoretic gel comprising at least one crosslinked temperature-responsive polymeric compound having an LCST is disclosed. A method of separating and recovering substances involves conducting the electrophoresis of a sample containing substances to be separated using the electrophoretic gel at a temperature below the LCST, excising each portion of the gel containing the substance to be separated and raising the temperature of the excised portion to a temperature above the LCST to shrink the excised portion to recover the substances.Type: GrantFiled: January 28, 1992Date of Patent: July 6, 1993Assignee: W. R. Grace & Co. -Conn.Inventors: Hiroshi Yoshioka, Yuichi Mori
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Patent number: 5196099Abstract: An electrophoretic matrix comprised of at least one water-insolubilized, temperature-responsive polymeric compound having an LCST is disclosed. The electro-phoretic matrix can change its hydrophilic/hydrophobic property by changing temperature. A method of using the electrophoretic matrix involves charging a sample onto the matrix and carrying out electrophoresis at a temperature above or below the LCST of the polymeric compound.Type: GrantFiled: June 22, 1992Date of Patent: March 23, 1993Assignee: W. R. Grace & Co.-Conn.Inventors: Yuichi Mori, Masato Mikami, Hiroshi Yoshioka
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Patent number: 5177238Abstract: An improved process for the production of allylphosphonic acid dialkyl esters in high yield and selectivity by the gradual addition of trialkyl phosphite to react with the appropriate allyl halide in the presence of a divalent nickel catalyst and, optionally, a polymerization inhibiting compound, e.g. hydroquinone.Type: GrantFiled: July 16, 1991Date of Patent: January 5, 1993Assignee: W. R. Grace & Co.-Conn.Inventors: Charles G. Carter, David R. Sterrenburg
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Patent number: 5175229Abstract: A class of hydrophilic prepolymers and hydrated polymer gels are disclosed which are characterized by their transparency, biocompatibility and resistance to nonspecific protein adsorption. At least 75%, preferably at least 90%, of the prepolymers are isocyanate-capped oxyethylene-based diols or polyols having molecular weight of about 7000-30,000. Essentially all of the hydroxyl groups of the diols or polyols are capped with polyisocyanate prior to formation of the hydrated polymer.Type: GrantFiled: July 3, 1991Date of Patent: December 29, 1992Assignee: W. R. Grace & Co.-Conn.Inventors: James A. Braatz, Clifton L. Kehr
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Patent number: 5169720Abstract: Polymer-coated medical and laboratory devices are disclosed which are characterized by their biocompatibility and resistance to nonspecific protein adsorption. The polyurea-polyurethane coatings of this invention are prepared from high molecular weight isocyanate end-capped prepolymers substantially or exclusively comprised of ethylene oxide units. At least 75%, preferably at least 90%, of the prepolymer units are oxyethylene-based diols or polyols having molecular weights of about 7000-30,000, with essentially all of the hydroxyl groups capped with polyisocyanate prior to formation of the hydrated polymer coating.Type: GrantFiled: March 6, 1991Date of Patent: December 8, 1992Assignee: W. R. Grace & Co.-Conn.Inventors: James A. Braatz, Aaron H. Heifetz, Clifton L. Kehr, Richard A. Wolfe
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Patent number: 5164057Abstract: An electrophoretic matrix comprised of at least one water-insolubilized, temperature-responsive polymeric compound having an LCST is disclosed. The electrophoretic matrix can change its hydrophilic/hydrophobic property by changing temperature. A method of using the electrophoretic matrix involves charging a sample onto the matrix and carrying out electrophoresis at a temperature above or below the LCST of the polymeric compound.Type: GrantFiled: September 19, 1991Date of Patent: November 17, 1992Assignee: W. R. Grace & Co.-Conn.Inventors: Yuichi Mori, Masato Mikami, Hiroshi Yoshioka
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Patent number: 5162572Abstract: An improved process for preparing alkyl nitroacetates by the gradual addition of nitric acid to a reaction vessel having therein a solution of alkyl nitroacetate and a carboxylic acid anhydride, optionally in the presence of an acid catalyst, at low temperatures to form an alkyl nitroacetoacetate intermediate which can thereafter be cleaved with a nucleophile to form an alkyl nitroacetate.Type: GrantFiled: December 19, 1991Date of Patent: November 10, 1992Assignee: W.R. Grace & Co.-Conn.Inventor: Sheldon B. Markofsky
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Patent number: 5142084Abstract: A novel process for rearranging triallyl phosphite to diallyl allylphosphonate ester is disclosed. The process involves heating triallyl phosphite in the presence of a soluble, inorganic bromide or iodide catalyst. The rearrangement process is useful in a 3-step process for the preparation allylphosphonic acid from trialkyl phosphite without the isolation of intermediates.Type: GrantFiled: October 11, 1991Date of Patent: August 25, 1992Inventors: Charles G. Carter, David R. Sterrenburg
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Patent number: 5105015Abstract: An improved process for selectively forming noncyclic, aliphatic polyamines from the corresponding aliphatic polynitriles by reacting the polynitrile with hydrogen at low temperature under a pressure of from 50 to 5,000 psi in a fixed bed reactor while continuously contacting the reactants with granular chromium and nickel promoted Raney.RTM. cobalt packed therein.Type: GrantFiled: June 4, 1991Date of Patent: April 14, 1992Assignee: W. R. Grace & Co.-Conn.Inventors: You-Jyh Lin, Stephen R. Schmidt, Ramin Abhari
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Patent number: 5097072Abstract: Polyamines are prepared via the batchwise hydrogenation of polynitriles by the gradual addition of the polynitrile into a fed-batch reactor which contains chromium promoted Raney.RTM. cobalt catalyst. The hydrogenation optionally is conducted in the presence of anhydrous ammonia. The polyamine product having amino groups which corresponds to the nitrile of the polynitrile is economically obtained in high selectivity and yield as the dominant product.Type: GrantFiled: March 21, 1991Date of Patent: March 17, 1992Assignee: W.R. Grace & Co.-Conn.Inventors: Gerald J. O'Neill, Albert H. Levesque
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Patent number: 5039458Abstract: A method of preparing a hydrophilic, biocompatible contact lens characterized by a surface which resists nonspecific protein adsorption. The method involves forming a prepolymer, at least 75% of which are oxyethylene-based diols and polyols having molecular weights of about 7000 to about 30,000. The prepolymer is subsequently gelled and hydrated to produce a hydrated polyurea-polyurethane polymer gel. The hydrated polymer gel is used to obtain a contact lens which resists nonspecific protein adsorption. Preferably, the contact lens are prepared by molding the prepolymer into a contact lens mold, prior to polymerization, to achieve the desired lens shape.Type: GrantFiled: November 7, 1989Date of Patent: August 13, 1991Assignee: W. R. Grace & Co.-Conn.Inventors: James A. Braatz, Clifton L. Kehr
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Patent number: 5022926Abstract: A method of removing iron contaminants in an aqueous system by introducing and maintaining within the system at least one ortho dihydroxyaromatic compound having at least one electron withdrawing group pendant from the aromatic ring and, further, a method of inhibiting calcium scale formation in the presence of iron contaminants by utilizing at least one dehydroxyaromatic compound in combination with calcium scale inhibitors.Type: GrantFiled: May 18, 1989Date of Patent: June 11, 1991Assignee: W. R. Grace & Co.-Conn.Inventors: Robert P. Kreh, Joseph T. Lundquist, Wayne L. Henry, John A. Kelly, Vincent R. Kuhn
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Patent number: 5011599Abstract: A hybrid chemical/biological process which is highly effective to destroy the herbicide, Atrazine, in wastewater solutions is herein disclosed. The process comprises subjecting the atrazine molecule in an aqueous carrier to ozone to produce the oxidized product, diamino-s-triazine and thereafter, metabolizing the diamine in soil having indigenous and selected microorganism capable of degrading the diamine to carbon dioxide. Also disclosed is a disposal system capable of preforming the process of the invention in a single system.Type: GrantFiled: February 13, 1990Date of Patent: April 30, 1991Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Philip C. Kearney, Mark T. Muldoon, Cathleen J. Somich
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Patent number: 4975293Abstract: A process of inhibiting enzymatic browning in raw fruit and vegetable juices comprising treating the juices with cyclodextrins, individually or in combination. Soluble cyclodextrins treatments may be added directly to the juices. In the alternative, isoluble cyclodextrins may be used as a packing in a column or in a batch treatment process. In effect, treatments of the invention tend to limit the extent or rate of enzymatic browning in the affected juices. Also disclosed are novel browning inhibiting compositions which are effective in controlling enzymatic browning in raw fruit and vegetable juices. The novel compositions are potential alternatives for presently used sulfites.Type: GrantFiled: January 11, 1988Date of Patent: December 4, 1990Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Kevin B. Hicks, Gerald M. Sapers, Paul A. Seib
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Patent number: 4975451Abstract: Compounds of the formula ##STR1## in which Ar is substituted or unsubstituted phenyl, naphthyl, or thienyl; and Ar.sup.1 is 3-phenoxyphenyl, 4-fluoro-3-phenoxyphenyl, 2-methyl[1-1'-biphenyl]-3-yl, or 6-phenoxy-2-pyridyl, exhibit pyrethroid-like insecticidal and acaricidal activity and are relatively nontoxic to fish.Type: GrantFiled: March 2, 1989Date of Patent: December 4, 1990Assignee: FMC CorporationInventors: Thomas G. Cullen, Scott McN. Sieburth, Gary A. Meier, John F. Engel, Leslie W. Stratton, Alan W. Fritz
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Patent number: 4956004Abstract: Herbicidal compounds of the formula ##STR1## in which Q is ##STR2## M is CH or N; Z is O, S, NH or alkylamino;R.sup.3 is H, OH, alkoxy, alkenyloxy or alkynyloxy, alkoxyalkoxy, alkenyloxylakoxy or alkynyloxyalkoxy, alkyl, substituted alkyl, OZ.sup.2 where Z.sup.2 is of a salt-forming group, amino, arylamino, alkylamino, alkenylamino, alkoxyamino, substituted alkoxyamino or --NHSO.sub.2 R.sup.5 where R.sup.5 is alkyl, haloalkyl or aryl;R.sup.1 is H, alkyl, halogen, haloalkyl, nitro, NH.sub.2, lower alkoxy, alkylthio or cyano;R.sup.2 is H, lower alkyl, lower alkenyl, lower alkynyl, halogen, CN, or COR.sup.3 ;R is H, lower alkyl, halogen, or lower alkoxy, R and R.sup.2 together constitute a double bond;R.sup.4 is H, halogen, lower alkyl, lower alkenyl, or lower alkynyl;R.sup.7 is H or lower alkyl;R.sup.b and R.sup.c are each H or together constitute a double bond; andR.sup.a, X and Y are so chosen that when Q is methoxy or propargyloxy, instead of Q having the formula given above, the compound is a herbicide.Type: GrantFiled: May 10, 1989Date of Patent: September 11, 1990Assignee: FMC CorporationInventor: George Theodoridis