Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Abstract: The intelligent distributed file system enables the storing of file data among a plurality of smart storage units which are accessed as a single file system. The intelligent distributed file system utilizes a metadata data structure to track and manage detailed information about each file, including, for example, the device and block locations of the file's data blocks, to permit different levels of replication and/or redundancy within a single file system, to facilitate the change of redundancy parameters, to provide high-level protection for metadata, to replicate and move data in real-time, and so forth.

Abstract: A method and system are directed towards enabling content security in a distributed environment. The system includes a data store for content associated with an application that may be tagged as exclusively memory resident at a client. The content may also be encrypted and digitally signed. When an authenticated client requests the content, it is provided at a constrained rate that enables a portion of the content to start execution on the client before the application associated with the content is completely downloaded. Additional portions of the content are provided to the client when the additional portions are required for execution by the application.

Abstract: A system (706, 714) is provided for a network signaling protocol bypass around a cryptographic device (1006, 1106). The system is comprised of a bypass means for receiving a packet (900) having a transport layer protocol header (908), for parsing a GIST signaling transport protocol identifier (950) from the transport layer protocol header, and for determining whether the GIST signaling transport protocol identifier is a NTLP or a NSIS signaling transport protocol identifier. If the GIST signaling transport protocol identifier is a NTLP or a NSIS signaling transport protocol identifier, the packet is bypassed around the cryptographic device. However, if the GIST signaling transport protocol identifier is not a NTLP or NSIS signaling transport protocol identifier, the packet is forwarded to the cryptographic device. A method is also provided for a network signaling protocol bypass around the cryptographic device.

Abstract: Disclosed is a process for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine. In the process, low-priced 2,2?-dithiosalicylic acid as starting material is subjected to bond formation reaction with 1-chloro-2-nitrobenzene in a basic aqueous solution, a nitro group reduction reaction is conducted, cyclization and chlorination reactions are simultaneously carried out in the presence of a equivalent amount of halogenating agent, a reaction with piperazine is continuously conducted without separation, and a reaction with 2-haloethoxyethanol is conducted, thereby it is possible to economically producing Quetiapine, that is, 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine, in an environmentally friendly manner.

Abstract: The present invention provides a polymer solid electrolyte excellent in thermal properties, physical properties and ion conductivity and being close to practical level; especially, a totally solid electrolyte and a composition for producing the same.

Abstract: A method of manufacturing a printed circuit board including embedded capacitors, composed of a polymer condenser laminate including a plurality of polymer condenser layers, each of which has a polymer sheet and a conductor pattern formed on the polymer sheet, and a via hole for interlayer connection therethrough, and a circuit layer formed on either surface or both surfaces of the polymer condenser laminate and having a circuit pattern and a via hole for interlayer connection therethrough. The printed circuit board manufactured by the method of the current invention has higher capacitance density per unit area than conventional embedded capacitor printed circuit boards, whereby capacitors having various capacitance values, such as multilayered ceramic capacitors having high capacitance, can be embedded in the printed circuit board, instead of being mounted thereon.

Abstract: Method for synchronizing stored data in one device (102, 106, 202, 206, 210) with other devices (102, 106, 202, 206, 210) at multiple levels of security classification. The methods and systems disclosed herein can advantageously utilize unique protocols and, optionally, cryptographic technologies to effect data synchronization in a secure manner.

Abstract: A method and system for authenticating and authorizing requesters interacting with content servers. A message including a request is forwarded from an upstream device and received by an intermediate device. The intermediate device authenticates the upstream device. Then, if the intermediate device is authorized to make decisions as to which sender may access the content server, the intermediate device determines whether the sender of the message has authority to access the content server as requested in the request. Otherwise, the message is forwarded towards the content server with an indication that the intermediate device authenticated the upstream device.

Abstract: Method (500) and system (402) for actively detecting and determining a range of a remotely located radio receiver (100). The invention also provides a method and system to determine whether a remote receiver (100) is receiving a transmitted signal (418) and the minimum necessary transmitter power required to establish a communication link to the receiver (100). Finally, the invention also provides a method and system to resolve directional ambiguities due to multipath.

Abstract: A system and method is provided for converting an input signal from a sequence of rectangular coordinate pairs to a sequence of polar coordinate pairs. The input signal includes a sequence of input vectors each including a pair of rectangular coordinates. A plurality of N input registers is configured to store an input vector of the input signal. The system includes a plurality of N CORDIC algorithm instances, each in communication with a corresponding one of the N input registers. Each CORDIC algorithm instance is configured to receive the input vector stored in the corresponding input register and to convert the received input vector to a corresponding output vector including a pair of polar coordinates. A recombiner is configured to receive the N output vectors and to recombine at least the N output vectors in sequence to form an output signal.

Abstract: This invention relates generally to the treatment of cathepsin or dynamin mediated diseases, such as proteinuria, cancer, and cognitive disease and related products. Diagnostic and other assays are also provided, as well as methods for podocyte cell gene transfer.

Abstract: Various directional coupler arrangements are disclosed. For instance, an apparatus includes first, second, and third conductive patterns disposed on a substrate. Each of these conductive patterns includes a first end and an opposite second end. Moreover, each of these conductive patterns includes a first protrusion at its first end and a second protrusion at its second end.

Abstract: A slide fastener with a slider locking mechanism comprising a slider body, a tab attached to the slider body rotatably, and a slider having a locking pawl formed integrally with the tab, wherein the locking pawl has a pawl portion fitted into between the elements, and the pawl portion comprises: a first contact surface which, when the tab is rotated after sliding operation of the slider is ended, contacts with a first element of an element row attached to a fastener stringer to stop the tab's rotation temporarily; and a second contact surface which, when the slider starts a forced movement in an element separating direction with the tab's rotation stopped, contacts with a second element to stop the slider's forced movement in a state where the tab restarts to rotate and the pawl portion is fitted into between the elements.

Abstract: A driving form switching apparatus enabling even a user of wheelchair who cannot freely use limb to easily change over a driving form by single hand self-operation. By using a differential gear mechanism or a combination mechanism comprising pinions and racks, the rotating, tilting and shifting motions of a steering lever are transmitted to two rotating shafts. Drums are directly coupled to the two rotating shafts, and the rotations of the two rotating shafts are transmitted to steering shafts through flexible wires as first connecting means. Also, the steering shafts for wheels are parallel- or cross-connected by second connecting means. Thus, the driving forms of a four-wheel drive vehicle such as back and forth traveling, counter-clockwise turning, clockwise turning, turning on the spot, parallel traveling, stopping and braking, etc, can be switched by a single-hand simple operation.

Abstract: A metallic double-sided element comprising a coupling head includes: thin flat plate portions; coupling convex portions projecting at a central portion in the right-left direction of the thin flat plate portion; right and left raised portions which are raised in the front surface-rear surface direction from the thin flat plate portion disposed on the right and left sides of each of the coupling convex portions and integrated with the body portion; and a coupling concave portion which is formed surrounded by the coupling convex portion, the right and left raised portions and the body portion, wherein each of the right and left raised portions has a slope portion which is inclined from a front edge toward the body portion such that the slope portion rises thereof, part of each side face of the right and left slope portions is integrated with part of right and left side faces of the coupling convex portion in a face bonding manner.

Abstract: A novel fluorescent substance for a light-emitting diode, emitting light of any one of three primary colors by excitation of an ultraviolet light-emitting diode. Alternatively, a novel fluorescent substance for a light-emitting diode, emitting light in a red region of a spectrum by excitation of a blue light-emitting diode. Na2SrSi2O6 is doped with Eu3+. Preferably, Eu3+ is added so as to account for 1 to 80 mol % in concentration in a host crystal, while sites of Si4+ in Na2SrSi2O6. are replaced by Al3+ and/or Ga3+. Alternatively, Ca3Si2O7 is doped with Ce3+ and Tb3+. Preferably, Ce3+ and Tb3+ are added so as to account for 0.1 to 80 mol % and 0.1 to 20 mol % in concentration in a host crystal, respectively. Still alternatively, Ca3Si2O7 is doped with Eu2+. Preferably, Eu2+ is added so as to account for 0.5 to 10 mol % in concentration in the host crystal.

Abstract: This method for manufacturing a surface-coated cutting insert includes clamping and holding a surface-coated cutting insert with a pair of rotary shafts which are rotatable around an axis, and jetting an abrasive fluid to the surface of the surface-coated cutting insert using at least one blasting gun while rotating the surface-coated cutting insert, thereby, conducting wet blasting.

Abstract: Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to tissue affecting the penis to treat erectile dysfunction (for instance, following prostate surgery) uses at least one implantable system control unit (SCU) producing electrical pulses delivered via electrodes and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered via one or more pumps and infusion outlets.

Abstract: A class D amplifier is provided. The class D amplifier includes an interpolator, a sampling rate converter, a pulse width modulator, a sigma-delta modulator, and a pulse width modulation (PWM) pulse generator (PPG). The sampling rate converter interpolates the output of the interpolator such that the sampling rate converter up-samples the interpolator output by a factor that is greater than one and less than two. The pulse width modulator outputs a multi-bit digital signal. The sigma-delta modulator performs sigma-delta modulation on the pulse width modulator output, the order of the sigma-delta modulation is programmable, and the output of the sigma-delta modulator is a multi-bit, digital signal. At least one of the orders to which the sigma-delta modulator can be programmed is greater than two. The PPG provides a pulse signal such that the width of each pulse is based on the value of the sigma-delta modulator output.