Abstract: Compositions including a liquid medium, a cyclodextrin component and a preservative component which has a reduced tendency to being complexed with the cyclodextrin component. In one embodiment, the preservative component is a chlorite component. Active components, such as pharmaceutically active components or drugs, preferably are included in the compositions.

Abstract: A battery element of a lead acid battery including a negative plate, a positive and a separator having a metal inhibiting additive that reduces the detrimental effects of at least one impurity on the negative plate.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes include a tube, an elongated member having a tip secured to its distal end, and a rod having a distal end portion. Methods for inserting an IOL into an eye using such apparatus are within the scope of the present invention.

Abstract: A method of treating a mammal comprises administering to a mammal an effective amount to provide a desired therapeutic effect in the mammal of a compound selected from the group consisting of those having the formula: and pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R1 and R2 each is selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms, the 2-imidazolin-2-ylamino group may be in any of the 5-, 6-, 7- or 8-positions of the quinoxaline nucleus, and R3, R4 and R5 each is located in one of the remaining 5-, 6-, 7- or 8-positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals containing 1 to 3 carbon atoms. Such compounds, when administered to a mammal, provide desired therapeutic effects, such as reduction in peripheral pain.

Abstract: Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.

Abstract: A method of vision correction comprising shaping first and second regions of a cornea to provide the first region with a first vision correction power and the second region with a second vision correction power which is different from the first vision correction power to enhance vision at first and second distances, respectively.

Abstract: Apparatus comprising first and second containers for holding contact lens care compositions and contact lens cases, respectively. The first container defines a chamber adapted to hold contact lens care composition and has an outlet. The second container defines a compartment and is adapted to be removably secured to the first container such that the second container extends outwardly away from the first container with the second container removably secured to the first container. A closure assembly is preferably provided and is coupled to the outlet of the first container. The closure assembly includes a passageway in fluid communication with the outlet and is adapted to provide for egress of the contact lens care composition from the chamber. A cap member is adapted to be moved between an open position in which the passageway is open and a closed position in which the passageway is closed.

Abstract: Flexible illuminators for external phototherapy are disclosed each having at least one light generating source, preferably a plurality of light-generating sources, on a flexible substrate. The flexible substrate may be a circuit board, and the light-generating source may be surface mount LEDs. Structures for diffusing light emitted from the discrete light-generating sources and/or for transferring heat away from a skin contact surface are provided. The illuminators may be formed so as to be wrapped around an infant or a limb of an adult, or may be provided in larger configurations, such as a mat. The illuminators may be passively or actively cooled so that the skin contact surface remains below a desired temperature.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a water soluble lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.

Abstract: Optically clear, reinforced cross-linked silicone elastomers of the invention contain 12 to 18 mol percent of aryl substituted siloxane units of the formula R4R5-SiO, end blockers containing siloxane units of the formula R1R2R3SiO.5, and dialkyl siloxane units of the formula R6R7-SiO. R1 and R2 are alkyl, aryl or substituted alkyl or substituted aryl groups, and R3 is an alkenyl group. R4 and R5 are phenyl or mono lower alkyl substituted phenyl groups. R6 and R7 are methyl or ethyl groups. The polymer has a degree of polymerization between 100 to 2000, and preferably approximately 250. The polymer also contains trimethyl silyl treated silica as a reinforcer in the weight ratio of approximately 15 to 45 parts of reinforcer to 100 parts of the polymer. After cross-linking, the polymer has properties of an optical refractive index which is at least 1.44, a type A durometer hardness of at least 35, tensile strength of at least 500 psi and tear strength of at least 20 pli.

Abstract: A stable physiologic balanced salt solution of a hyaluronate salt, such as sodium hyaluronate, is provided which contains calcium ion, for example, in the form of calcium chloride or calcium acetate, and magnesium ion, for example in the form of magnesium chloride or magnesium acetate, together with sodium chloride, potassium chloride or potassium acetate, sodium acetate, sodium citrate and water, and optionally bicarbonate, dextrose and glutathione disulfide, preservatives and other conventional ingredients employed in irrigating solutions. This solution is used as a visco-elastic ophthalmic device during ophthalmic surgery.

Abstract: An apparatus for inserting an intraocular lens through an incision into an eye includes a tube defining a hollow passage, an injector rod longitudinally moveable within the hollow passage and a force transfer assembly coupled to the injector rod. The injector rod has a distal portion adapted to contact the intraocular lens within the hollow passage of the tube to urge the intraocular lens distally through the hollow passage. The force transfer assembly is adapted to transfer sufficient force to the injector rod to effect the longitudinal movement of the injector rod and is further adapted to prevent the transfer of sufficient force to the injector rod to effect the longitudinal movement of the injector rod in response to an increased amount of force being applied to the force transfer assembly.

Abstract: A battery element of a lead acid battery including a negative plate, a positive and a separator having an organic polymer having phosphonic functionality in the negative plate to improve capacity maintenance.

Abstract: An IOL implantable in an eye comprising an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes comprises a tube, a rod having a distal end portion, and a tip carried by the distal end portion. The tip is softer than the distal end portion of the rod. Methods for inserting an IOL into an eye using such apparatus are within the scope of the present invention.

Abstract: New methods for producing intraocular lenses (IOLs) include a combination of steps which provide outstanding pull strength between the fixation member of the IOL and the optic of the IOL without requiring the lens body region of the fixation member to have enlarged anchor structures. In one embodiment, the present methods include providing an optic member having a recess; providing a fixation member having a lens bonding region free of enlarged anchor structures; placing the lens bonding region into the recess; and thereafter doing at least one of reducing the size of the recess and increasing the cross-sectional area of the lens bonding region. The lens bonding region of the fixation member is thereby secured to the optic member.

Abstract: An apparatus for inserting a folded intraocular lens through an incision into an eye comprising a tube defining a hollow passage, the tube having an ejection port through which said intraocular lens is passed from the hollow passage into an eye, an injector rod longitudinally movable within the hollow passage of the tube, the injector rod having a distal segment adapted to contact the folded intraocular lens within the hollow passage of the tube to urge the folded intraocular lens distally through the hollow passage, a housing including a distal portion adapted to hold the tube, and a proximal portion coupled to the distal portion, and a rotation assembly located relative to the distal portion so that the distal portion is axially rotated relative to the proximal portion as the injector rod is moved distally through the tube.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye. The interior wall is configured, for example, roughened, so that a portion of the interior wall remains out of contact with the deformable optic of the IOL as the IOL passes through the hollow space. Advantageously reduced amounts of force are required to pass the IOL through the hollow space.

Abstract: Apparatus for insertion of intraocular lenses into the eye are disclosed. In one embodiment, the apparatus comprises a loading chamber and an injection portion. The loading chamber has a proximal end and a distally extending opening. The loading chamber defines a first lumen and is adapted to receive an intraocular lens in an unfolded state at the distally extending opening and to fold the intraocular lens and maintain the intraocular lens folded as the intraocular lens is placed in the first lumen. The injection portion defines a second lumen aligned with the first lumen and is adapted to receive the folded intraocular lens from the first lumen in the second lumen. The injection portion has an open distal end through which the folded intraocular lens from the second lumen passes to be inserted into an eye.