Abstract: This invention provides methods for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable from the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis from dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated with the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medically relevant condition.

Abstract: The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant, measured with respect to human Id1 protein and/or mouse Id1 protein, equal to or greater than 1×108/molar. The antibody has no substantial cross-reactivity with other family Id proteins such as Id2, Id3, or Id4, or other endogenous proteins present in the cells that express Id1 protein. The high specificity and high affinity of the rabbit monoclonal antibodies of the present invention allows sensitive and specific detection and/or quantitation of Id1 protein in biological samples. The antibodies are useful in immunochemical-based assays such as ELISA, western blot, and immunohistochemical staining.

Abstract: Novel compounds of 2-(substituted arylmethyl)-3-(substituted phenyl)-2H-indazoles and 1-(substituted arylmethyl)-3-(substituted phenyl)-1H-indazoles are synthesized, and useful as anti-angiogenic agents.

Abstract: A process for preparing lipids which contain docosahexaenoic acid (DHA) and/or docosapentaenoic acid (DPA) is disclosed. The process includes the steps of cultivating in a medium a microorganism which belongs to the genus Ulkenia having the ability to produce DHA and/or DPA and recovering the lipids from the culture. The process may further include the step of separating DHA and/or DPA from the lipids.

Abstract: A motor vehicle (1) with a hatchback (H1) comprising lateral frame parts (H3) rising in the direction of travel, between which in a rear window (H4) is received in at least one position and which rest on a rear section (8) of lateral members of the bodywork of the vehicle (6) when the hatchback (H1) is in a closed position, forming part of the outer surface of the vehicle. According to the invention, when the hatchback (H1) is opened, it can be moved with the most forward-lying area (HF) thereof counter to the direction of travel (F) and a passageway (D1) enabling the roof parts (P1;P2;H4) to move inside the bodywork of the vehicle (6) is opened up in the overlapping area when the hatchback (H1) is closed.

Abstract: An upper-completion single trip system is described which includes a hydraulic internal seal receptacle assemble. The HISR assembly includes an overshot assembly selectively connected to a mandrel assembly. Once fully actuated, relative axial motion therebetween is allowed, which provides a spacer apparatus for the tubing above and below the HISR assembly. A shearable anchor latch as well as an indexing mule shoe are also provided in the HISR system, which allow multiple completion steps to be performed in a single trip. The HISR system is particularly well-suited for installation of permanent downhole gauges or intelligent systems—installations where rotation of pipe is prohibited. The system is also particularly well-suited for submersible pumps. A method of performing multiple completion activities in a single trip is also described.

Abstract: The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.

Abstract: A composition for inhibiting or preventing the formation of emulsions in the presence of treating acids during the acid stimulation of hydrocarbon wells is provided. The composition includes an alkyl aryl sulfonic acid or salt thereof, an acetylenic alcohol, an alkyl diphenyl oxide sulfonic acid or derivative thereof, in an alkyl alcohol solvent. The disclosed compositions can be used in an acid treatment solution, such as 15% hydrochloric acid, to prevent and resolve live acid and spent acid emulsions for a wide range of crude oils.

Abstract: A mobile apparatus and method for recycling an invert emulsion based drilling fluid, in which the invert emulsion based drilling fluid includes an oleaginous component and an aqueous component. The apparatus includes an emulsion breaking tank, a water treatment tank, a filter press, and hydrocarbon filters. The method includes: mixing said invert emulsion drilling fluid with a emulsion breaker, wherein the emulsion breaker is a mixture of an alkyl glucoside and an alkane sulfonate; and separating the oleaginous component of the invert emulsion drilling fluid from the aqueous component of the invert emulsion drilling fluid. The method preferably utilizes an emulsion breaker that is a combination of an anionic surfactant, a nonionic surfactant and an alkyl polyglycoside surfactant.

Abstract: This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae III, IIIa, and IIIb, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae IIIa and IIIb, which are potent and have a good oral bioavailability.

Abstract: The invention relates to a device for automatically supplying feed and/or drink to an animal, comprising at any rate at least one trough, a flap, a control unit for controlling the flap, so that the flap is capable of being put in an open position and in a closed position for giving the animal access to the trough, respectively preventing the animal from having access to the trough, and an identification device for identifying the animal and for emitting an identification signal that is indicative of the identified animal.

Abstract: Disclosed are Bacillus thuringiensis strains comprising novel crystal proteins which exhibit insecticidal activity against coleopteran insects including red flour beetle larvae (Tribolium castaneum) and Japanese beetle larvae (Popillia japonica). Also disclosed are novel B. thuringiensis crystal toxin genes, designated cryET33 and cryET34, which encode the colepteran-toxic crystal proteins, CryET33 (29-kDa) crystal protein, and the cryET34 gene encodes the 14-kDa CryET34 crystal protein. The CryET33 and CryET34 crystal proteins are toxic to red flour beetle larvae and Japanese beetle larvae. Also disclosed are methods of making and using transgenic cells comprising the novel nucleic acid sequences of the invention.

Abstract: The invention is directed to a method for improving the performance of electrophoretic displays by modifying the electrical properties of the display cells.

Abstract: A system for deriving hash values for packets in a packet processing system is described. In this system, hash derivation logic is configured to derive a hash value for the packet responsive to a key that drives processing of the packet. The hash value is useful for supporting additional processing of the packet, such as link aggregation and equal cost multi-path.

Abstract: The present invention is directed to a proteorhodopsin mutant having improved optical characteristics. One improved optical characteristic is having a lower pH (pKrh) at which equal concentrations of the acidic and basic spectral form of the proteorhodopsin molecules are present. Another improved optical characteristic is having a smaller difference in maximum absorption wavelength between the basic and the acidic form. The mutant comprises a mutation in a conserved amino acid residue of a proteorhodopsin variant, which causes spectral shifts. A preferred mutation site is a conserved histidine residue at amino acid position 75 of Bac31A8, or position 77 of Hot75m1, or its equivalent position of a proteorhodopsin variant. Another preferred mutation site is a conserved arginine residue at amino acid position 94 of Bac31A8, or position 96 of Hot75m1, or its equivalent position of a proteorhodopsin variant.

Abstract: The present invention relates to transgenic plants, such as wheat or maize, comprising plant cells having SEQ. ID. NO. 1 and seeds derived from those plants. It also relates to the use of said seed for the preparation of a flour which in turn is used for the preparation of food and/or feed such as dough, batters, pastries, cookies, pasta, wafers, bread and/or confectionery. The thus obtained gliadin-free foodstuff is beneficial for feeding patients suffering from coeliac disease and/or other forms of gluten intolerance.

Abstract: Cement compositions containing an expandable material are disclosed. The compositions are suitable for use in oil and gas wells. An example of such an expandable material is a polymer encapsulated chemical that expands upon heating. Examples of cement compositions containing polymer encapsulated isobutane or isopentane are disclosed. The use of cement compositions containing an expandable material can reduce the formation of micro-annulus or other deleterious physical properties in the set cement.

Abstract: The present invention relates to a tamperhead structure including metal and/or non-metal components. The structure may include a top plate and a bottom plate separated by a plurality of spacers. The head structure may also include a plurality of plungers attached to the bottom plate and a stripper shoe attached to each of the plurality of plungers. Each of the components of the tamperhead structure may be fabricated from metal material, non-metal material or a combination of both metal and non-metal materials.

Abstract: The present invention relates to an improved EPD which comprises both the traditional up/down switching and the in-plane switching modes. In other words, the improved EPD has dual switching modes. The monochrome EPDs of the present invention are capable of displaying highlight color of choice which is different from the text. For example, white background, blue text, and red highlight can be shown in any selected areas of the display. Furthermore, the full color EPDs of the present invention are capable of displaying high contrast images of high color saturation. Both high quality black and white states are possible in the full color displays of the present invention. The EPDs of the present invention do not need complex circuitry design, and are compatible with low cost and high yield roll-to-roll manufacturing processes.