Abstract: The present invention relates to a compound which is N-(4-{4-[(6-butyl-8-quinolinyl)oxy]-1-piperidinyl}butyl)ethanesulfonamide and salts thereof, processes for its preparation, to compositions containing it and to its use in the treatment of various diseases, such as allergic rhinitis.

Abstract: A fluid dispensing device is disclosed having a body housing a pump action fluid discharge device having a dispensing nozzle. The fluid dispensing device comprises a body defining a cavity and a dispensing nozzle having a dispensing orifice, a fluid discharging device housed in the cavity, the fluid discharging device having a hollow casing defining a reservoir for containing a volume of fluid and a plunger slidingly engaged within the hollow casing, the plunger having a tubular portion which extends from a first end of the hollow casing for co-operation with the dispensing nozzle to enable pumped delivery of fluid from the reservoir to the dispensing nozzle, wherein the dispensing orifice of the dispensing nozzle is provided with a reversible stopper.

Abstract: A medicament dispensing system for treatment of a disease is disclosed, the system comprising: (i) detecting means for detecting one or more biochemical marker(s) indicative of the disease; (ii) electronic processing means for processing information obtainable from the detecting means; and (iii) medicament dispensing means for dispensing a quantity of medicament determinable by the electronic processing means. The medicament dispensing system is particularly useful for the treatment of respiratory disorders, such as asthma, or for other disorders which may be treated by inhalation, either through the nose or mouth.

Abstract: Compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.

Abstract: An actuation indicator which includes a drums sub-assembly including a rotatable actuation indicator wheel, a rocking ratchet pawl for rotating the indicator wheel in a set direction and a rocking mechanism for the pawl driven by a slipping clutch arrangement, wherein the slipping clutch arrangement includes a slipping clutch spring engaged at one end to a pinion of a rack and pinion assembly and at a second end to the ratchet pawl is described.

Abstract: A medicament dispenser for use in the storage, presentation and/or dispensing of medicament comprising a body shaped for receipt of a medicament container. In association with the body, there is a first transceiver for transmitting and receiving data. A medicament container is receivable by the body. In association with the medicament container, there is a second transceiver for transmitting and receiving data. Data is transferable in two-way fashion from the first transceiver to the second transceiver. The medicament dispenser may be supplied in kit of parts form.

Abstract: A fluid dispenser (5, 105)is disclosed having a housing (9, 109)and a pump action fluid discharge device (8, 108). The pump action fluid discharge device (8, 108) is arranged to be actuated by a pair of opposing levers (20, 21); (120, 121) which are pivotally connected to part of the housing (9, 109). When the levers (20, 21); (120, 121) are squeezed together the fluid discharge device (8, 108) is urged towards a nozzle (11, 111) causing a single dose of fluid to be dispensed from the nozzle (11, 111).

Abstract: There is provided a medicament dispenser for use with a medicament carrier having a plurality of pockets for containing medicament wherein said pockets are spaced along the length of and defined between two peelable sheets secured to each other, said dispenser having an internal mechanism for accessing said medicament contained within said medicament carrier. The internal mechanism comprises a carrier drive means; indexing means and clutch means, in communication therebetween. The clutch means comprises a gearing surface defining plural gear engagement positions; and plural gear teeth for engaging said plural gear engagement positions. The plural gear teeth are arranged such that at any one time only a single gear tooth engages a single gear engagement position.

Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.

Abstract: One aspect of the invention provides an automated system for performing repeated testing using an impactor which comprises a cup manifold defining multiple impaction cups, an impactor head defining transfer passages, and a nozzle manifold which defines multiple nozzles and is disposable between the cup manifold and the impactor head, so that in the assembled impactor a route is defined for through-flow via the impaction cups, the nozzles and the transfer passages. The system comprises an impaction station for performing impaction testing using the assembled impactor; a cup manifold recovery station for recovering sample material from the impactor cups in a solvent; an impactor head cleaning station; and at least one handling system for assembling the impactor for impaction, and for subsequently disassembling the impactor and delivering the cup manifold and the impactor head to their respective stations.

Abstract: There is provided a method of loading a container with a defined quantity of product comprising closing off a perforation in a perforated plate; directing powder into the closed-off perforation by the sweeping action of a first director blade spaced from said perforated plate; and transferring the contents of the perforation to said container. The method is characterized by relative rotary motion of the perforated plate and said first director blade. Suitable apparatus is also provided.

Abstract: A compound of formula (I): wherein X represents O or S; R1 represents C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkylmethyl or C3-8 cycloalkenyl any of which optionally may be substituted by one or more methyl groups or halogen atoms or R1 represents aryl, substituted aryl, heteroaryl or substituted heteroaryl; R2 represents hydrogen, methyl, which may be in either the ? or ? configuration, or methylene; R3 and R4 are the same or different and each independently represents hydrogen, halogen or a methyl group; and ?represents a single or a double bond; or a physiologically acceptable salt or solvate thereof, and pharmaceutical formulations and methods of use thereof.

Abstract: The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.

Abstract: A medicament dispenser comprising: (i) a housing having an outlet; (ii) a medicament container locatable within said housing; (iii) an electronic dose counter associated with said outlet, wherein said dose counter comprises a first sensor for directly detecting a medicament release dispensible from said medicament container through said outlet is disclosed.

Abstract: There is provided a crystalline complex comprising a compound of formula (I) in which the crystal lattice is stabilized by the presence of a guest molecule, characterized in that the crystalline complex is of space group P212121 having unit cell dimensions of about 12.5±1.0 §, 15±1.0 §, and 16.2±1.0 § when determined at either 120K or 150K.

Abstract: The present invention is directed to compounds of formula (I): wherein R1 represents C4-C7 branched alkyl group, a bicycloalkyl group, or a C5-C6 cycloalkyl which optionally may be substituted with a C1-C4 alkyl group; R2 represents hydrogen, a methyl group, which may be in either the ? or ? configuration, or a methylene group; R3 and R4 are the same or a different group and each independently represents hydrogen, halogen or a methyl group; represents a single or a double bond; and physiologically acceptable solvates thereof, physiologically functional derivatives thereof, pharmaceutical compositions comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.