Patents Represented by Attorney John J. McDonnell

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  • Method for cholesterol lowering
    Patent number: 4459310
    Abstract: This invention encompasses a new use for 16-loweralkyl-16-hydroxy prostaglandins such as misoprostol. This class of prostaglandin has been found useful in lowering cholesterol blood levels in patients with hypercholesterolemia.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: July 10, 1984
    Assignee: G.D. Searle & Co.
    Inventor: Esam Z. Dajani
  • 2-Cyanosteroids
    Patent number: 4459235
    Abstract: The invention relates to novel 2-cyanosteroids of Formula I which are useful for the induction of menses and the termination of pregnancy.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: July 10, 1984
    Assignee: G. D. Searle & Co.
    Inventors: Leland J. Chinn, Karlene W. Salamon
  • Psyllium hydrophilic mucilloid composition
    Patent number: 4459280
    Abstract: This invention relates to a method of increasing the dispersibility and mixability of psyllium hydrophilic mucilloid by applying a film of hydrolyzed starch oligosaccharide, a mono-or di-saccharide, a polyglucose, or a polymaltose.
    Type: Grant
    Filed: July 23, 1982
    Date of Patent: July 10, 1984
    Assignee: G. D. Searle & Co.
    Inventors: John A. Colliopoulos, David B. Paul, James G. Young
  • Process for isolating organic compounds and lithium salt complexes useful in said process
    Patent number: 4452994
    Abstract: An improved process for isolating organic compounds from crude product or reaction mixtures by dissolving said crude product or reaction mixture in a suitable solvent, contacting the resulting solution with a lithium salt to form a solid metal salt complex, separating, and thereafter recovering a pure product by decomposing the lithium salt complex.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: June 5, 1984
    Assignee: G. D. Searle & Co.
    Inventors: John B. Hill, Robert A. Erickson
  • Dipeptide sweetener-metal complexes
    Patent number: 4448716
    Abstract: The invention relates to metal complexes of dipeptide sweeteners, such as L-aspartyl-L-phenylalanine methyl ester, with improved dissolution rate, solubility and stability.
    Type: Grant
    Filed: March 4, 1982
    Date of Patent: May 15, 1984
    Assignee: G. D. Searle & Co.
    Inventor: Josef H. Tsau
  • Method and intermediates for producing .alpha.-L-aspartyl-L-phenylalanine
    Patent number: 4440677
    Abstract: This invention encompasses a method and intermediates for preparing a commercial sweetening agent, .alpha.-L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydride by reaction with acetic anhydride. N-acetoacetyl-L-aspartic anhydride is reacted with L-phenylalanine methyl ester to provide N-acetoacetyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester which is converted to .alpha.-L-aspartyl-L-phenylalanine methyl ester by reaction with hydroxylamine hydrochloride.
    Type: Grant
    Filed: June 20, 1983
    Date of Patent: April 3, 1984
    Assignee: G. D. Searle & Co.
    Inventors: Hugh L. Dryden, John B. Hill
  • Dipeptide sweetener sulfate and sulfonate salts
    Patent number: 4439460
    Abstract: Aspartyl dipeptide sweetener sulfate and alkyl sulfonate salts are described which have high thermal stability and a fast rate of dissolution in aqueous media. These salts can be almost universally substituted in place of sugar and are effective in baking and cold drink applications.
    Type: Grant
    Filed: June 1, 1982
    Date of Patent: March 27, 1984
    Assignee: G. D. Searle & Co.
    Inventors: Josef H. Tsau, James G. Young
  • Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins
    Patent number: 4420568
    Abstract: An immunochemical method and reagent compounds for determining ligands in a sample. The reagent compounds are derivatives of a triazinylaminofluorescein and are represented by the structural formula ##STR1## wherein Y is halo or lower alkyl; andR is a ligand-analog wherein said ligand-analog has at least one common epitope with said ligand so as to be specifically recognizable by a common antibody.The reagent compound and an antibody specific to the ligand are added to the sample in a fluorescence polarization immunoassay.
    Type: Grant
    Filed: November 30, 1981
    Date of Patent: December 13, 1983
    Assignee: Abbott Laboratories
    Inventors: Chao-Huei J. Wang, Stephen D. Stroupe, Michael E. Jolley
  • Assimilation test for identifying yeasts
    Patent number: 4379841
    Abstract: The disclosure relates to a culture medium containing as a sole carbon source 4-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid or a mixture thereof, and to an assimilation test for identifying yeasts utilizing such a culture medium.
    Type: Grant
    Filed: October 2, 1981
    Date of Patent: April 12, 1983
    Assignee: Abbott Laboratories
    Inventor: Billy H. Cooper
  • Determination of thyroxine binding globulin
    Patent number: 4341865
    Abstract: This invention encompasses a method for measuring unsaturated thyroxine binding globulin in serum comprising intermixing with the serum:(i) thyroxine irreversible enzyme inhibitor conjugate which binds to the unsaturated thyroxine binding globulin thereby inactivating the irreversible enzyme inhibitor portion of the conjugate;(ii) an enzyme which is irreversibly inhibited by the thyroxine irreversible enzyme inhibitor conjugate unbound by the thyroxine binding globulin; and(iii) a substrate for the enzyme; and monitoring the enzyme substrate reaction.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: July 27, 1982
    Assignee: Abbott Laboratories
    Inventor: Houston F. Voss
  • Culture media for inactivation of bacterial growth inhibitors
    Patent number: 4340679
    Abstract: This invention encompasses methods and reagents for inactivation of bacterial growth inhibitors present in blood, serum or plasma. It has been found that salicylates and closely related compounds will neutralize bacterial growth inhibitors present in the blood of many patients. The addition of salicylate to conventional growth medium also provides a reagent for monitoring the antibiotic levels in blood by enabling measurement of the effect of the antibiotic against a standard test organism without interference from the bacterial growth inhibitor present in sera.
    Type: Grant
    Filed: May 8, 1980
    Date of Patent: July 20, 1982
    Assignee: Abbott Laboratories
    Inventors: George M. Fukui, Herbert J. Spencer, Laurens R. Williams, II
  • Detection of neisseria gonorrhoeae
    Patent number: 4332890
    Abstract: A procedure for detection of Neisseria gonorrhoeae in a microbial growth culture. Lysates of the suspect organism are tested by reverse passive hemagglutination with particles sensitized with antibodies to eleven N. gonorrhoeae strains, ATCC 31397, 31398, 31399, 31400, 31401, 31402, 31403, 31404, 31405, 31406, and 31407.
    Type: Grant
    Filed: May 15, 1978
    Date of Patent: June 1, 1982
    Assignee: Abbott Laboratories
    Inventor: Alan S. Armstrong
  • Laboratory assay device
    Patent number: 4320087
    Abstract: A device useful in the performance of a variety of immunologic and biochemical assays which comprises a container enclosing a solid phase reagent with an adsorbent and a retaining means for prohibiting the removal of said solid phase reagent is disclosed. The device is particularly well adapted to perform heterogeneous immunoassays and to permit processing large numbers of said immunoassays by facilitating the separation of assay medium from the solid phase reagents.
    Type: Grant
    Filed: January 23, 1978
    Date of Patent: March 16, 1982
    Assignee: Abbott Laboratories
    Inventors: Kue H. Chau, Robert A. Beard
  • Method and apparatus for collecting blood samples
    Patent number: 4311482
    Abstract: This invention encompasses methods and apparatus for collecting blood samples. It has been discovered that p-aminobenzoyldiethylaminoethanol (procaine) is unexpectedly potent in stabilizing blood samples against platelet release reactions. Methods and apparatus of this invention are particularly useful for collecting blood samples for subsequent platelet factor 4 determination.
    Type: Grant
    Filed: October 9, 1979
    Date of Patent: January 19, 1982
    Assignee: Abbott Laboratories
    Inventors: Erwin F. Workman, Jr., Deborah M. Clark
  • Multiple cuvette assembly
    Patent number: D265124
    Type: Grant
    Filed: March 19, 1979
    Date of Patent: June 22, 1982
    Assignee: Abbott Laboratories
    Inventor: Harold S. Terk
  • Test tube rack or the like
    Patent number: D265126
    Type: Grant
    Filed: May 8, 1980
    Date of Patent: June 22, 1982
    Assignee: Abbott Laboratories
    Inventor: Glenn L. Beall
  • Sample cup
    Patent number: D266358
    Type: Grant
    Filed: June 2, 1980
    Date of Patent: September 28, 1982
    Assignee: Abbott Laboratories
    Inventor: Ralph M. Kerns
  • Premature nipple or the like
    Patent number: D271798
    Type: Grant
    Filed: March 4, 1981
    Date of Patent: December 13, 1983
    Assignee: Abbott Laboratories
    Inventor: Antonino Araujo, Jr.
  • Sample cup or the like
    Patent number: D273807
    Type: Grant
    Filed: June 4, 1981
    Date of Patent: May 8, 1984
    Assignee: Abbott Laboratories
    Inventor: James T. Holen
  • Reagent cassette (or the like)
    Patent number: D273987
    Type: Grant
    Filed: August 20, 1981
    Date of Patent: May 22, 1984
    Assignee: Abbott Laboratories
    Inventors: James T. Holen, Julius S. Becker, Robert Case