Abstract: The present invention comprises compounds of the formula ##STR1## and the biologically acceptable acid addition salts thereof wherein R.sub.1 represents hydrogen, or lower alkyl having 1-4 carbon atoms; R.sub.2 represents p-hydroxybenzyl or benzyl; R.sub.3 represents an alkyl having 1-6 carbon atoms; R.sub.4 represents amino or guanidino; R.sub.5 represents p-nitrophenyl, methylnitrophenyl, dinitrophenyl, naphthyl, or nitronaphthyl; and n is 3 or 4.

Abstract: The present invention encompasses a method for reducing offensive odors in poultry houses comprising adding at least 10 pounds of composted cow manure per ton of poultry manure. The method of the present invention substantially reduces offensive odor in poultry houses especially ammonia odor and thereby provides a healthier environment for poultry and poultry workers. Since the ammonia loss to the environment is reduced, the nitrogen is retained in the poultry manure providing a product with higher nitrogen content.

Abstract: The present invention comprises compounds of the formula ##STR1## and the biologically acceptable acid addition salts thereof, wherein R.sub.1 represents an alkylene having 2-4 carbon atoms; R.sub.2 is selected from the group consisting of amino and quanyl; R.sub.3 is selected from the group consisting of nitrophenyl, methylnitrophenyl, dinitrophenyl, naphthyl and nitronaphthyl; X represents halo or lower alkyl having 1-4 carbon atoms; and n is 3 or 4. The compounds of the present invention are analytical reagents useful for measuring proteolytic enzymes such as thrombin and trypsin. The enzymatic hydrolysis of the invention compounds provides a chromogenic amine by which the proteolytic enzyme concentration can be determined spectrophotometrically.

Abstract: The present invention encompasses a compound of the formula ##STR1## and the biologically acceptable acid addition salts thereof wherein R is hydrogen, tosyl, carbobenzoxy or benzoyl. These compounds are chromogenic substrates for proteolytic enzymes useful in antithrombin III determination.

Abstract: A method for determining glycosylated hemoglobin in blood samples which involves liberating hemoglobins from red blood cells by chemical or physical means and reacting non-glycosylated hemoglobin with an allosteric site binding substance which reacts with the allosteric binding site of non-glycosylated hemoglobin and thereby alters the distribution between allosteric forms of the hemoglobins and measuring the change. This method is useful in monitoring glucose metabolism for detecting and controlling diabetes.

Abstract: The present invention encompasses a stabilized platelet factor 4 immunoassay standard comprising an aqueous solution containing 10 to 100 ng/ml of platelet factor 4, carrier protein, and an effective stabilizing amount of heparin, as well as .sup.125 I labeled platelet factor 4 reagent stabilized in the same manner. These reagents are useful for testing blood plasma for activation of the coagulation system.

Abstract: The present invention encompasses an internal reflectance spectrometer comprising:(a) a prism adaptable for optically coupling test sample to one surface thereof;(b) a means for irradiating the test sample with light of wave length absorbed by the test sample, said means directing light to enter the test sample from the prism surface having test sample thereon at an angle between the critical angle and about 35.degree. less than the critical angle, said light refracted in the test samples so that said light is internally reflected from the test sample remote from the prism surface; and(c) a means for detecting the internally reflected light.The instrument of the present invention is a full range absorbtion spectrometer.

Abstract: A method for analyzing blood serum or plasma wherein the blood serum or plasma is treated with about 1.4 or more volumes of acetonitrile, propionitrile, tetrahydrofuran or mixtures thereof to precipitate proteins and to provide a supernatant. The separated supernatant is subsequently examined for a component of interest.

Abstract: The reaction of 1-(halo/cyano/sulfonyloxy)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazin es with an amine affords the corresponding 1-(substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines which compounds are useful anti-inflammatory or anti-diarrheal agents.

Abstract: The present invention encompasses acid addition salts of a compound of the formula ##STR1## wherein: R.sub.1 represents phenylsulfonyl, benzoyl, carbobenzoxy, and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, phenyl, or hydroxy substituted derivatives thereof; or alkanoyl having 2-12 carbon atoms; R.sub.2 represents alkyl having 1-10 carbon atoms, alkoxyalkyl having 2-6 carbon atoms, cycloalkyl having 5-7 carbon atoms, benzyl and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, carboxy, hydroxy, or substituted derivatives thereof; R.sub.3 represents hydrogen or guanyl, and m is 3 or 4.Compounds of the present invention are useful as analytical reagents. Enzymatic hydrolysis provides --S--R.sub.2 which can be further reacted with 5,5'-dithiobis (2-nitrobenzoic acid) to provide a colored product by which the enzyme concentration can be determined spectrophotometrically.

Abstract: Method for converting dextro rotatory chitin to levo rotatory chitin comprising dissolving chitin in a composition containing dimethyl acetamide, N-methyl-pyrrolidone or mixture thereof and lithium chloride.

Abstract: The present invention encompasses the acid addition salts of a compound of the formula ##STR1## wherein R.sub.1 represents phenylsulfonyl, benzoyl, carbobenzoxy, and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, phenyl, or hydroxy substituted derivatives thereof; or alkanoyl having 2-12 carbon atoms; and R.sub.2 represents alkyl having 1-10 carbon atoms, or alkoxyalkyl having 2-6 carbon atoms, cycloalkyl having 5-7 carbon atoms, or benzyl and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, hydroxy, carboxy, or phenyl substituted derivatives thereof.Compounds of the present invention are useful as analytical reagents. Enzymatic hydrolysis provides --S--R.sub.2 which can be further reacted with 5,5'-dithiobis (2-nitrobenzoic acid) to provide a colored product by which the enzyme concentration can be determined spectrophotometrically.

Abstract: Compounds of the formula ##STR1## wherein R is phenyl cyclohexyl or lower alkyl containing 1-6 carbon atoms; R" is hydrogen or methyl; R'" is alkenyl or alkynyl having 3-5 carbon atoms; R' is hydrogen, tetrahydrofuran-2-yl tetrahydropyran-2-yl or trialkylsilyl wherein the alkyl contains 1-4 carbon atoms. Compounds of the present invention are useful in synthesizing prostaglandin like molecules which are active anti-secretory agents.

Abstract: The invention relates to copolymers of 5-hydroxycytidylic acid and at least one other polynucleotide selected from cytidylic acid and monomers derived therefrom by bromination. The polymers of the invention are prepared by the bromination of polycytidylic acid and subsequent hydrolysis of the product. The copolymers of the invention demonstrate antiviral properties in vivo.

Abstract: The present invention encompasses compounds of the formula: ##STR1## wherein n is 0 or 1; Y represents ethylene or vinylene; R represents hydrogen or lower alkyl having 1-7 carbon atoms; R', R", R'" each individually represent hydrogen or methyl; Ar represents phenyl, halosubstituted phenyl, alkyl substituted phenyl wherein the alkyl contains 1-4 carbon atoms, alkoxy substituted phenyl wherein the alkoxy contains 1-4 carbon atoms, trifluoromethylphenyl, or biphenyl; and the wavy line indicates R or S stereochemistry.

Abstract: The present invention encompasses an antimicrobial composition comprising an extract of lytic enzymes from Physarum. These lytic enzymes are particularly effective antimycotic agents when used in conjunction with conventional antimycotic agents.

Abstract: The reaction of 1-(halo/cyano/sulfonyloxy)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazin es with an amine affords the corresponding 1-(substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines which compounds are useful anti-inflammatory or anti-diarrheal agents.

Abstract: The present invention encompasses a vaccine for the prevention of disease associated with feline leukemia virus which comprises an effective amount of an adjuvant and about 10.sup.5 -10.sup.7 feline lymphoblastoid cells chronically infected with feline leukemia virus and having viral associated antigen on their surface wherein the virus and cells are inactivated by chemical or physical means without destroying immunogenicity.

Abstract: The present invention encompasses compounds of the formula ##STR1## AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF WHEREIN R represents hydrogen, alkanoyl having 1 to 7 carbon atoms, or lower alkyl having 1 to 7 carbon atoms; X and Y represent alkylene having 1 to 3 carbon atoms and Ar, Ar', and Ar" represent phenyl, halosubstituted phenyl, lower alkyl substituted phenyl wherein the lower alkyl contains 1 to 4 carbon atoms; and Ar'" represents phenyl, pyridyl, lower alkyl substituted phenyl wherein the lower alkyl contains 1 to 4 carbon atoms or halosubstituted phenyl. Compounds of the present invention are prepared by reaction of triarylalkanoyl halide with appropriately substituted piperidine followed by subsequent reduction of the resulting amide. Compounds of the present invention are potent antidiarrheal compounds with unexpected separation of antidiarrheal and central nervous system properties.

Abstract: The present invention relates to compounds of the formula ##STR1## having the [(X-substituted)phenyl]phenylmethyl moiety attached to the 2, 3, or 4 position of the piperidine ring and wherein X is hydrogen, halo, trifluoromethyl, (lower alkyl) containing 1-7 carbon atoms, or (lower alkoxy) containing 1-7 carbon atoms, A represents alkylene containing 1-3 carbon atoms, and R.sub.1 and R.sub.2 represent (lower alkyl) containing 1-7 carbon atoms or R.sub.1 and R.sub.2 together with N represent piperidino or morpholino and the pharmaceutically acceptable salts thereof. The compounds of this invention are prepared by the reaction of an appropriate [(X-substituted)phenyl]phenylmethylpiperidine with an appropriate 1-halo-2-dialkylaminoalkane. The compounds of this invention are useful as anti-arrythmic agents.