Patents Represented by Attorney, Agent or Law Firm John L. Haack
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Patent number: 8342403Abstract: A method and optical reader system for label-independent detection as defined herein. The reader system includes: a launch beam; a first lens; a receptacle for receiving at least one optical biosensor article, the article having a mask on one face, and the mask having at least one aperture there through for receiving and transmitting radiation from the collimated launch beam; an angular separator; and an imager to record the image of the optical biosensor article.Type: GrantFiled: October 19, 2010Date of Patent: January 1, 2013Assignee: Corning IncorporatedInventor: Robert Adam Modavis
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Patent number: 8338116Abstract: Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed.Type: GrantFiled: October 26, 2011Date of Patent: December 25, 2012Assignee: Corning IncorporatedInventors: Ye Fang, Ann M. Ferrie, Norman H. Fontaine, Joydeep Lahiri, Po Ki Yuen
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Patent number: 8314049Abstract: A porous ceramic body including a major phase of beta-spodumene and a minor phase of mullite, the aggregate composition of a batch in weight percents of LiAlSi2O6, SiO2, and Al6Si2O13 are as defined herein. Also disclosed is a method for making a porous ceramic article is and includes: mixing inorganic batch ingredients including sources of silica, alumina, and lithia, with a liquid and an organic binder to form a plasticized batch mixture; forming a green body; and heating to the porous ceramic article, comprised of a major phase of beta-spodumene and a minor phase of mullite.Type: GrantFiled: November 30, 2010Date of Patent: November 20, 2012Assignee: Corning IncorporatedInventors: Keith Norman Bubb, Cameron Wayne Tanner
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Patent number: 8313898Abstract: A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.Type: GrantFiled: February 19, 2009Date of Patent: November 20, 2012Assignee: Corning IncorporatedInventors: Ye Fang, Elizabeth Tran, David H. Randle, Anthony Glenn Frutos
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Patent number: 8278410Abstract: Fused thiophene (FT) compounds, FT polymers, FT containing articles, and methods for making and using the FT compounds and polymers thereof of the formulas, as defined herein.Type: GrantFiled: February 28, 2011Date of Patent: October 2, 2012Assignee: Corning IncorporatedInventors: Mingqian He, Thomas Mark Leslie, Weijun Niu
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Patent number: 8278346Abstract: Di-tin fused thiophene (FT) compounds, FT polymers, such as of the formula -{-(FTx)-(Ar)m-}n-, FT polymer containing articles or devices, and methods for making and using the FT compounds and polymers thereof of the formulas, as defined herein.Type: GrantFiled: August 6, 2010Date of Patent: October 2, 2012Assignee: Corning IncorporatedInventors: Mingqian He, Weijun Niu
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Patent number: 8257965Abstract: The present invention overcomes the problems and disadvantages associated with prior art arrays by providing an array comprising a plurality of biological membrane microspots associated with a surface of a substrate that can be produced, used and stored, not in an aqueous environment, but in an environment exposed to air under ambient or controlled humidities. Preferably, the biological membrane microspots comprise a membrane bound protein. Most preferably, the membrane bound protein is a G-protein coupled receptor, an ion channel, a receptor serine/threonine kinase or a receptor tyrosine kinase.Type: GrantFiled: January 29, 2010Date of Patent: September 4, 2012Assignee: Corning IncorporatedInventors: Ye Fang, Anthony G. Frutos, Steven J. Jonas, Peter J. Kalal, Joydeep Lahiri
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Patent number: 8243276Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.Type: GrantFiled: November 30, 2009Date of Patent: August 14, 2012Assignee: Corning IncorporatedInventors: James Gregory Couillard, Norman Henry Fontaine, Guangshan Li, Anping Liu, Jinlin Peng, Donnell Thaddeus Walton
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Patent number: 8242299Abstract: A composite including a cross-linked interpenetrating network of an organic polymer including an alcohol adduct of, for example, a glycidyl ether substituted acrylate or epoxy substituted acrylate; and a sol-gel polymer. The composite having a low or no-shrinkage characteristic, and a method for making and using the composite, as defined herein.Type: GrantFiled: May 25, 2010Date of Patent: August 14, 2012Assignee: Corning IncorporatedInventor: Nikita Sergeevich Shelekhov
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Patent number: 8217183Abstract: ??-di-R-substituted fused thiophene (DCXFT4) compounds, and a method for making a compound of the formula (V): where each R is a C4 to C25 hydrocarbylene, the method including di-acylating tetra-bromo dithiophene (I); contacting the bromo-dithiophene compound (II) with a 2-mercaptoacetate to form cyclized fused thiophene (III); converting fused thiophene (III) to the corresponding diacid (IV); and decarboxylating the diacid (IV) to the fused thiophene (V), of the formulas as defined herein.Type: GrantFiled: May 18, 2010Date of Patent: July 10, 2012Assignee: Corning IncorporatedInventors: Mingqian He, Jieyu Hu, James R. Matthews, Weijun Niu
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Patent number: 8218586Abstract: A wavelength tunable system including a laser having a lasing cavity and an external cavity, the cavities having a common optical axis; a reflective grating fixed in the external cavity; a collimating lens between the lasing cavity and the reflective grating; and an adjustable reflective mirror defining one end of the external cavity and optically coupled to the fixed reflective grating, the adjustable reflective mirror pivots about the fixed reflective grating, and a method of use as defined herein.Type: GrantFiled: November 13, 2009Date of Patent: July 10, 2012Assignee: Corning IncorporatedInventors: Thomas James Dunn, Jack Weston Frankovich, Christopher Alan Lee
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Patent number: 8168399Abstract: Described herein are supports for assaying an analyte and methods of making and using thereof.Type: GrantFiled: June 9, 2011Date of Patent: May 1, 2012Assignee: Corning IncorporatedInventors: Anthony G. Frutos, David Henry
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Patent number: 8163561Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.Type: GrantFiled: November 30, 2009Date of Patent: April 24, 2012Assignee: Corning IncorporatedInventors: Norman Henry Fontaine, Joydeep Lahiri, Guangshan Li, Anping Liu, Jinlin Peng
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Patent number: 8158340Abstract: Described herein are methods for detecting conformational changes in bioentities.Type: GrantFiled: October 25, 2006Date of Patent: April 17, 2012Assignee: Corning IncorporatedInventor: Shawn M. O'Malley
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Patent number: 8148092Abstract: The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution.Type: GrantFiled: May 20, 2009Date of Patent: April 3, 2012Assignee: Corning IncorporatedInventors: Ye Fang, Ann M. Ferrie, Norman H. Fontaine, Joydeep Lahiri, Po Ki Yuen
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Patent number: 8133422Abstract: A batch mixture including ceramic-forming ingredients, a pore former, a binder comprising an ammonium salt of an alkylated cellulose binder, and a liquid vehicle, as defined herein. Also disclosed is a method for producing a ceramic precursor article as defined herein having excellent extrusion properties.Type: GrantFiled: October 30, 2008Date of Patent: March 13, 2012Assignee: Corning IncorporatedInventors: Patricia Ann Beauseigneur, Kevin Ying Chou
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Patent number: 8129198Abstract: A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.Type: GrantFiled: August 11, 2010Date of Patent: March 6, 2012Assignee: Corning IncorporatedInventors: Ye Fang, Ann M. Ferrie, Yulong Hong, Brian L. Webb
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Patent number: 8105822Abstract: A biosensor or cell culture article including: a substrate having a bio-compatible layer. The bio-compatible layer can be obtained from surface oxidation of a substrate coating comprising the reaction product of a suitable oxidizable polymer and modifier compound, such as a triamine, attached to the oxidizable polymer. Methods for making the biosensor or cell culture article and methods for performing an assay of a ligand with the biosensor article are also disclosed.Type: GrantFiled: November 18, 2008Date of Patent: January 31, 2012Assignee: Corning IncorporatedInventor: Terry T. Goodrich
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Patent number: 8101405Abstract: A biosensor article including a substrate having nanoparticles on the substrate surface, the nanoparticle including: a polymer of formula (I) where (x), (y), (z), R, R?, R?, S, W, and X, are as defined herein. Methods for making the biosensor article or cell culture article and methods for performing an assay of a ligand with the biosensor article are also disclosed.Type: GrantFiled: November 17, 2009Date of Patent: January 24, 2012Assignee: Corning IncorporatedInventors: Bertrand De Lambert, David Henry
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Patent number: 8088877Abstract: A curable composition and a process for using the curable composition within a grating-coupled waveguide (GCW) sensor are disclosed. The composition can be used for facile replication of optical components, specifically those used in a label-independent detection system where operation of the waveguide is dependent on the detailed formation of micro and nano size patterns. The photo or electron beam curable composition has low viscosity (?500 cPs) and cures to an optically clear material with high glass transition temperature (?70° C.), low shrinkage on cure, low outgassing, and low extractables.Type: GrantFiled: February 12, 2009Date of Patent: January 3, 2012Assignee: Corning IncorporatedInventors: Paul J. Shustack, Kimberly S. Wayman