Patents Represented by Attorney Kathleen R. S. Page

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  • .alpha.-substituted-3-benzyl-benzofurans
    Patent number: 5622974
    Abstract: This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzofurans which are .alpha.-substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: April 22, 1997
    Assignee: Eli Lilly and Company
    Inventor: Brian S. Muehl
  • Derivatives of A82846
    Patent number: 5591714
    Abstract: New N-alkyl and N-acyl derivatives of A82846A, A82846B, A82846C and PA-42867-A are provided. The new glycopeptide derivatives are useful for the treatment of susceptible bacterial infections, especially infections due to Gram-positive microorganisms.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: January 7, 1997
    Assignee: Eli Lilly and Company
    Inventors: Ramakrishnan Nagarajan, Amelia A. Schabel
  • Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
    Patent number: 5578720
    Abstract: This invention provides for crystalline hydrochloride C.sub.1 -C.sub.3 alcohol solvate forms of the compound of formula (I): ##STR1## In particular, crystalline hydrochloride ethanol, methanol, and propanol solvates are disclosed.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: November 26, 1996
    Assignee: Eli Lilly and Company
    Inventors: Jane G. Amos, Perry C. Heath, Douglas E. Prather, John E. Toth
  • One step process for production of dirithromycin
    Patent number: 5578713
    Abstract: The disclosure relates to a new process for the synthesis of the macrolide antibiotic dirithromycin in crystalline form. The process is carried out in a single reaction vessel whereby an acetal dissolved in acetonitrile, in the presence of an acid catalyst, is hydrolyzed to the related hemiacetal which then reacts directly with erythromycylamine to form crystalline dirithromycin.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: November 26, 1996
    Assignee: Eli Lilly and Company
    Inventor: John M. McGill, III
  • Tilmicosin formulation
    Patent number: 5574020
    Abstract: An aqueous, injectable, sustained release tilmicosin formulation comprises 250-350 mg/ml of tilmicosin and 250 mg/ml of propylene glycol, and has a pH adjusted to 6.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: November 12, 1996
    Assignee: Eli Lilly and Company
    Inventors: Paul R. Klink, Thomas D. Thomson
  • Method for selectively deactivating catalase while retaining damino acid oxidase activity
    Patent number: 5559006
    Abstract: "A method for selectively deactivating catalase while retaining D-amino acid oxidase activity is disclosed. The catalase and oxidase are both present in whole cells or a cell-free extract. The method comprises combining the whole cells or the cell-free extract with a basic solution at a pH between about 11 and about 12. The catalase activity is eliminated and the oxidase activity is unaffected. This results in the production of a solution which contains oxidase activity but no catalase activity. The whole cells and cell-free extract are preferably from Triginopsis variabilis.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: September 24, 1996
    Assignee: Eli Lilly and Company
    Inventor: Jeffrey T. Vicenzi
  • Antibiotic A82810
    Patent number: 5552386
    Abstract: New polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
    Type: Grant
    Filed: April 2, 1993
    Date of Patent: September 3, 1996
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Raymond C. Yao
  • Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
    Patent number: 5550231
    Abstract: This invention provides for crystalline hydrochloride C.sub.1 -C.sub.3 alcohol solvate forms of the compound of formula (I): ##STR1## In particular, crystalline hydrochloride ethanol, methanol, and propanol solvates are disclosed. Also disclosed are processess for preparing and using the above compounds.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: August 27, 1996
    Assignee: Eli Lilly and Company
    Inventors: Jane G. Amos, Perry C. Heath, Douglas E. Prather, John E. Toth
  • Carbanilide anticoccidials
    Patent number: 5541224
    Abstract: The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified carbanilide compound. The present invention is also directed to anticoccidial methods, animal feed premixes, and animal feeds employing the specified carbanilide compound and a polyether antibiotic.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: July 30, 1996
    Assignee: Eli Lilly and Company
    Inventor: George O. P. O'Doherty
  • Biotransformation of glycopeptide antibiotics
    Patent number: 5534420
    Abstract: New glycopeptides prepared by biotransformation of a vancomycin-type antibiotic by an Acinomadura citrea culture (NRRL 18382), which are useful intermediates, and methods of preparing the biotransformed intermediates by adding a vancomycin-type glycopeptide to a growing culture of Actinomadura citrea NRRL 18382 and continuing fermentation under submerged aerobic conditions, are provided.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: July 9, 1996
    Assignee: Eli Lilly and Company
    Inventors: Manuel Debono, Robert M. Logan, Gary G. Marconi, R. Michael Molloy, Milton J. Zmijewski, Jr.
  • Anticoccidial method
    Patent number: 5502040
    Abstract: The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed to anticoccidial methods, animal feed premixes, and animal feeds employing two active agents. In such combined therapy, a first substance is a polyether antibiotic, and the second substance is a designated o-phenylenediamine, benzimidazole, or benzimidazoline.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: March 26, 1996
    Assignee: Eli Lilly and Company
    Inventor: George O. P. O'Doherty
  • Ractopamine and growth hormone combinations
    Patent number: 5453418
    Abstract: Combined administration of a growth hormone related substance and ractopamine, cimaterol, clenbuterol, L-644,969, or albuterol to swine provides improved growth feed efficiency, and carcass quality. Administration of ractopamine, cimaterol, clenbuterol, L-644,969, or albuterol to swine that also receive growth hormone related substance reduces greater than normal blood sugar and insulin levels.This application is a continuation of application Ser. No. 07/694,628, filed May 2, 1991, now abandoned, which is a continuation-in-part of application Ser. No. 07/164,675, filed Mar. 7, 1988, now abandoned.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: September 26, 1995
    Assignee: Eli Lilly and Company
    Inventors: David B. Anderson, D. Jay Jones, Alvin L. Melliere
  • Use of disulfonyl methanes for the control of parasites
    Patent number: 5449681
    Abstract: The present invention is directed to the use of disulfonyl methane compounds for the control of parasites in vertebrate animals.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: September 12, 1995
    Assignee: Eli Lilly and Company
    Inventor: David I. Wickiser
  • 1,5-diphenyl-3-formazancarbonitril parasiticides
    Patent number: 5340804
    Abstract: The present invention is directed to the use of 1,5-diaryl-3 -formazancarbonitrile compounds for the control of parasites in vertebrate animals.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: August 23, 1994
    Assignee: Eli Lilly and Company
    Inventor: David I. Wickiser
  • Anticoccidial methods
    Patent number: 5331003
    Abstract: The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed to anticoccidial methods, animal feed premixes, and animal feeds employing two active agents. In such combined therapy, a first substance is a polyether antibiotic, and the second substance is a designated o-phenylenediamine, benzimidazole, or benzimidazoline.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: July 19, 1994
    Assignee: Eli Lilly and Company
    Inventor: George O. P. O'Doherty
  • Ractopamine for pre-and peripubertal female bovidae
    Patent number: 5308870
    Abstract: The present invention is directed to a method for increasing the milk producing capacity of a female bovidae, by administering an effective amount of an active agent to the bovidae during its mammary glands' allometric growth phase preceding first conception. The active agent is ractopamine or a physiologically acceptable salt.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: May 3, 1994
    Assignee: Eli Lilly and Company
    Inventor: Deana L. Hancock
  • Monensin derivatives
    Patent number: 5217993
    Abstract: The present invention is directed to a class of novel C-25-monohydrazine derivatives, and C-25, C-26-bishydrazine derivatives, of the polyether monensin. The derivatives are useful in animal husbandry.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: June 8, 1993
    Assignee: Eli Lilly and Company
    Inventor: George O. P. O'Doherty
  • Fish production
    Patent number: 5216029
    Abstract: This invention is directed to the use of the compound ractopamine for improved production of fish.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: June 1, 1993
    Assignee: Eli Lilly and Company
    Inventors: David B. Anderson, Edward L. Veenhuizen
  • Process for protein particle size reduction using a fluid-energy mill
    Patent number: 5021554
    Abstract: The particle size of amorphous protein material is reduced to uniform particulates without protein decomposition or loss of activity by passing the material through a fluid-energy mill.
    Type: Grant
    Filed: February 24, 1989
    Date of Patent: June 4, 1991
    Assignee: Eli Lilly and Company
    Inventor: William W. Thompson
  • Synergistic treatment method
    Patent number: 4997825
    Abstract: The concentration of endogenous growth hormone in the bloodstream of an economic mammal is increased by the simultaneous administration of an estrogen and a growth hormone releasing factor.
    Type: Grant
    Filed: October 20, 1989
    Date of Patent: March 5, 1991
    Assignee: Eli Lilly and Company
    Inventor: Jack F. Wagner