Patents Represented by Attorney, Agent or Law Firm Lahive & Cockfield
  • CD10-activated prodrug compounds
    Patent number: 7771962
    Abstract: The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing the prodrug are also disclosed.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: August 10, 2010
    Assignee: Medarex, Inc.
    Inventors: Christopher R. Bebbington, Matthew H. Nieder, Pina M. Cardarelli, Sanjeev Gangwar, Lesley B. Pickford, Chin Pan
  • Methods and compositions for controlling appetite and modulating insulin sensitivity
    Patent number: 7767402
    Abstract: The invention features methods of enhancing whole body insulin sensitivity by modulating the endoplasmic reticulum (ER) stress response pathway in adipose cells. In one aspect, the methods involve targeting chaperone proteins important in the ER stress response pathway, for example, BiP and ERO-1. Another aspect features targeting the upstream transcription factors (e.g., CHOP-1 and XBP-1) of the genes encoding the chaperone proteins (and/or other ER proteins). Screening assays for identification of modulators of these ER proteins and/or transcription factors are also featured.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: August 3, 2010
    Assignee: University of Massachusetts
    Inventor: Silvia Corvera
  • Method and apparatus for integrated modeling, simulation and analysis of chemical and biological systems having a sequence of reactions, each simulated at a reaction time determined based on reaction kinetics
    Patent number: 7769576
    Abstract: A system for modeling, simulating and analyzing chemical and biochemical reactions includes a modeling environment for constructing a model of a chemical or biochemical system comprising a plurality of chemical reactions. Each chemical reaction has a probability distribution associated therewith based on the kinetics of the particular chemical reaction. The probability distribution may be set by a user, determined automatically, or experimentally determined. The system also includes a simulation engine accepting as input said constructed model of the chemical or biochemical system and generating as output an expected result. The simulation engine calculates a reaction time for each chemical reaction based on the probability distribution associated with the particular chemical reaction. An analysis environment communicates with the simulation engine and displays the expected result.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: August 3, 2010
    Assignee: The MathWorks, Inc.
    Inventors: Ricardo E. Paxson, Joseph F. Hicklin
  • Fuel cell stack with dummy cell
    Patent number: 7767355
    Abstract: A fuel cell stack 10 includes a stacked structure 14 composed of a plurality of electricity-generating cells stacked successively, and dummy cells arranged at both ends in a stacking direction of the stacked structure 14. Each dummy cell 16 each includes a conductive plate 52 and first and second metallic separators 54, 56 which sandwich the conductive plate 52. The conductive plate 52 is formed of a metallic plate having substantially the same shape as that of the electrolytic membrane electrode assembly 22. The first and second metallic separators 54, 56 are structured in the same manner as the first and second metallic separators 24, 26 of the electricity-generating cell 12.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: August 3, 2010
    Assignee: Honda Motor Co., Ltd.
    Inventors: Hideo Kato, Katsumi Hayashi, Shigeru Inai, Ryo Jinba, Masahiko Sato, Yohei Hidaka
  • Fuel cell system and charge amount adjustment method for energy storage
    Patent number: 7767352
    Abstract: When it is detected that the ignition switch is turned off a short period of time after the ignition switch turned on at the temperature below the freezing point, the charge threshold of a capacitor is changed to a larger charge threshold C for increasing the amount of electrical energy charged in the capacitor based on the charge threshold C. The capacitor is used for performing a scavenging process for a sufficient period of time. At the time of starting operation of the fuel cell system at the temperature below the freezing point the next time, using the electrical energy of the capacitor, a fuel cell is warmed rapidly by a heater or the like to start operation of the fuel cell system.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: August 3, 2010
    Assignee: Honda Motor Co., Ltd.
    Inventors: Chihiro Wake, Koichiro Miyata, Jumpei Ogawa
  • Imidazotriazines and imidazopyrimidines as kinase inhibitors
    Patent number: 7767675
    Abstract: The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: August 3, 2010
    Assignee: Incyte Corporation
    Inventors: Jincong Zhuo, Meizhong Xu, Chunhong He, Colin Zhang, Ding-Quan Qian, Brian Metcalf, Wenqing Yao
  • Hierarchical references or links in modeling environments
    Patent number: 7769570
    Abstract: Methods and systems for making a reference to a resource in modeling environments are disclosed. The resource to which the reference is made includes the data of the system designed and/or executed in the modeling environments. The system includes subsystems and hierarchical references are made to the data of the subsystems. In response to users' action to select one of the hierarchical references to the resource, the hierarchical references included in the selected hierarchical reference are provided to users so that the users may navigate the data of the subsystems and select one of the subsystems. If users activate the selected hierarchical reference, the data corresponding to the selected hierarchical reference is retrieved and provided to the users.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: August 3, 2010
    Assignee: The MathWorks, Inc.
    Inventor: Pieter J. Mosterman
  • Dynamically sizing a collaboration of concurrent computing workers based on user inputs
    Patent number: 7765561
    Abstract: A dynamic collaboration of processes in a concurrent computing environment is disclosed. A user can modify the size of collaboration or the number of processes that execute a computational job after the processes have been launched on the concurrent computing environment. A launched or running process can establish a communication channel with other processes in the collaboration so that the launched or running process can join the collaboration to execute the job. The user can also release a process from the collaboration so the released process can join a new collaboration to execute a different job. Once a job is completed, the processes can leave the collaboration, and the processes are then free to join a new collaboration subsequently.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: July 27, 2010
    Assignee: The MathWorks, Inc.
    Inventor: Edric Ellis
  • Transforming graphical objects in a graphical modeling environment
    Patent number: 7765529
    Abstract: In a graphical modeling environment, one of a selection of transformation operations is performed on a graphical object by first selecting the graphical object. A user may select a particular transformation operation to be executed on the graphical object from a list of transformation operations displayed to the user. A transformed graphical object derived from the selected graphical object may be then automatically created without retrieving the transformed graphical object from a library or other source.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: July 27, 2010
    Assignee: The MathWorks, Inc.
    Inventors: Sanjai Singh, John Ciolfi
  • Antagonists of interleukin-15
    Patent number: 7763434
    Abstract: Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R?-subunit and that are incapable of transducing a signal through either the ?- or ?-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the ?- or ?-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: July 27, 2010
    Assignee: Immunex Corporation
    Inventors: Kenneth H. Grabstein, Dean K. Pettit, Raymond J. Paxton
  • Exhaust gas purifying apparatus for internal combustion engine
    Patent number: 7758833
    Abstract: An exhaust gas purifying apparatus for an internal combustion engine is provided with a NOx removing device and a particulate filter in an exhaust system. A temperature of the exhaust system is detected. A switching control is performed for alternately performing a process for removing sulfur oxide accumulated in said NOx removing device and a regeneration process for burning particulates trapped in said particulate filter, when it is determined to be necessary to perform at least one of the removal of the sulfur oxide in said NOx removing device and the regeneration of the particulate filter. The switching control is performed according to the detected exhaust system temperature.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: July 20, 2010
    Assignee: Honda Motor Co., Ltd.
    Inventors: Akira Odajima, Isao Kaneko, Shingo Tsuruta, Yoshihiko Watanabe, Hidetaka Maki
  • RNA interference pathway genes as tools for targeted genetic interference
    Patent number: 7759463
    Abstract: Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: July 20, 2010
    Assignee: University of Massachusetts
    Inventors: Craig C. Mello, Hiroaki Tabara, Andrew Fire, Alla Grishok
  • Fuel cell having a seal member
    Patent number: 7759014
    Abstract: A power generation cell includes a membrane electrode assembly, and a cathode side metal separator and an anode side metal separator sandwiching the membrane electrode assembly. A seal member covers inner surfaces of inlet through holes. The seal member includes a plurality of flow grooves and a plurality of receivers. The flow grooves guide a fuel gas from the inlet through holes to a fuel gas flow field through an inlet buffer. The receivers directly contact an anode.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: July 20, 2010
    Assignee: Honda Motor Co., Ltd.
    Inventors: Toshiya Wakahoi, Hiroyuki Tanaka, Yosuke Fuji
  • Fuel cell
    Patent number: 7758991
    Abstract: A coolant flow field is formed on a surface of a second metal separator. Further, a rubber bridge dividing the coolant flow field and a coolant supply passage is formed on the surface. The rubber bridge includes a plurality of channels connecting the coolant flow field and the coolant supply passage, a plurality of grooves between the channels, and a partition closing the grooves to prevent the flow of a coolant in the respective grooves.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: July 20, 2010
    Assignee: Honda Motor Co., Ltd.
    Inventors: Shuhei Goto, Kazuo Nunokawa, Takahiro Takeshita, Ken Takahashi, Narutoshi Sugita, Hiroyuki Tanaka
  • Simplified data signal support for diagramming environment languages
    Patent number: 7761273
    Abstract: A computer-implemented method may include defining an input bus signal in a graphical block diagram model by associating the input bus signal with a first group of signals, at least two of the first group of signals having a different data type; defining an output bus signal in the graphical block diagram model by associating the second bus signal with a second group of signals, each of the second group of signals corresponding to one of the first group of signals; defining an input to a non-virtual operation block in the graphical block diagram model as the input bus signal; defining an output to the non-virtual operation block in the graphical block diagram as the output bus signal; and simulating an operation performed on the input bus signal by the non-virtual operation block, the operation being performed on each of the first group of signals and output to each of the second group of signals.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: July 20, 2010
    Assignee: The MathWorks, Inc.
    Inventors: Peter Szpak, Matthew Englehart
  • Methods and compositions for enhancing the efficacy and specificity of RNA silencing
    Patent number: 7750144
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: July 6, 2010
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, György Hutvágner, Dianne Schwarz, Martin Simard
  • Integrated instrument driver network
    Patent number: 7752005
    Abstract: An application development environment is provided. A selection of instruments is provided. A selection of an instrument is received. The selected instrument is automatically queried for an identification information of an instrument driver. An absence of the instrument driver is determined in the application development environment. The instrument driver is identified at a remote storage location, the instrument driver having metadata. The identified instrument driver is verified based on the metadata. The verified instrument driver is automatically retrieved from the remote storage location. The retrieved instrument driver is installed in the application development environment. Communications are established between the application development environment and the selected instrument via the installed driver.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: July 6, 2010
    Assignee: The Math Works, Inc
    Inventor: Patrick L. Edson
  • Bread roll
    Patent number: D618878
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: July 6, 2010
    Inventor: Harold Brian Nakan
  • Mobile toy robot
    Patent number: D620538
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: July 27, 2010
    Assignee: Robonica (Proprietary) Limited
    Inventors: Johannes Petrus Poolman, Christian Kunneke, Johannes Gerhardus Benade, Pieter Etienne Dreyer
  • Premium filter
    Patent number: D621001
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: August 3, 2010
    Assignee: Tana Industries Ltd
    Inventors: Eldad Maziel, Avner Sadot, Yoav Dracher