Patents Represented by Attorney Matthew J. Russo

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  • Apoptosis signal-regulating kinase 1 inhibitors
    Patent number: 8178555
    Abstract: The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: May 15, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Edcon Chang, Stephen L. Gwaltney, Angie Vassar
  • Glucokinase activators
    Patent number: 8173645
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: May 8, 2012
    Assignee: Takeda San Diego, Inc.
    Inventors: Zacharia Cheruvallath, Jun Feng, Prasuna Guntupalli, Stephen L. Gwaltney, Joanne Miura, Mark Sabat, Mingnam Tang
  • Glucokinase activators
    Patent number: 8163779
    Abstract: Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: April 24, 2012
    Assignee: Takeda San Diego, Inc.
    Inventors: Zacharia Cheruvallath, Jun Feng, Prasuna Guntupalli, Stephen L. Gwaltney, Joanne Miura, Mark Sabat, Mingnam Tang, Haxia Wang
  • Renin inhibitors
    Patent number: 8148367
    Abstract: Disclosed are compounds, pharmaceutical compositions, kits, articles of manufacture, methods of using, and methods of preparing compounds having the formula: wherein the variables are as defined herein. The disclosed compounds are inhibitors of Renin.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: April 3, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Lily Kwok, Betty Lam, Zhe Li, Zhiyuan Zhang
  • Renin inhibitors
    Patent number: 8138168
    Abstract: The invention relates to compounds having the formulae: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: March 20, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Benjamin Jones, Stephen W. Kaldor, Walter Keung, Andre A. Kiryanov, Zhe Li, Jeffrey A. Stafford, John Tyhonas, Craig Behnke
  • Renin inhibitors
    Patent number: 8133898
    Abstract: The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:—wherein the variables are as defined herein.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: March 13, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Stephen L. Gwaltney, Zhiyuan Zhang, Betty Lam
  • Renin inhibitors
    Patent number: 8129538
    Abstract: The invention relates to compounds having the formula: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: March 6, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Walter Keung, Zhe Li
  • Substituted 7,8,9,10-tetrahydro-5H-dipyrido[1,2-a:3?,2?-e]pyrazin-6(6aH)-ones
    Patent number: 8124606
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R5, R6, R7, R11, X, and m are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: February 28, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • Substituted 6a,7,8,9-tetrahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-ones
    Patent number: 7928105
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R5, R6, R7, R31, u, and X are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: April 19, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • Amino acids with affinity for the ?2?-protein
    Patent number: 7388023
    Abstract: Certain ?-amino acids that bind to the alpha-2-delta (?2?) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed are methods of making the ?-amino acids.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: June 17, 2008
    Assignee: Warner-Lambert Company LLC
    Inventors: Peter Garth Blazecka, Joseph Richard Bozelak, Norman Lloyd Colbry, Timothy Thomas Curran, Annise Paige Goodman, Kevin E. Henegar, Garrett Hoge, Paul D. Johnson, Augustine Tobi Osuma, Mark Stephen Plummer, Jacob Bradley Schwarz, Derek Clinton Vrieze, Ji Zhang
  • Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts
    Patent number: 7230135
    Abstract: P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: June 12, 2007
    Assignee: Warner Lambert Company LLC
    Inventors: Garrett Stewart Hoge, II, Om Prakash Goel
  • Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
    Patent number: 7122678
    Abstract: The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: October 17, 2006
    Assignee: Warner-Lambert Company
    Inventors: Justin Stephen Bryans, David Christopher Horwell, Andrew John Thorpe, David Juergen Wustrow, Po-Wai Yuen
  • Process for preparing single enantiomers of 5,5,5,5?,5?,5?-hexafluoroleucine and protected analogs
    Patent number: 6974879
    Abstract: A process for synthesizing L and D-5,5,5,5?,5?,5?-hexafluoroleucine and protected analogs is disclosed. These compounds have utility in the preparation of fluorous peptides and proteins, which display interesting and unusual properties including strong self-association and an affinity for lipid bilayers.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: December 13, 2005
    Assignee: Warner-Lambert Company
    Inventors: James T. Anderson, Edward Neil Marsh, Peter Laurence Toogood
  • Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate
    Patent number: 6933390
    Abstract: The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of further catalysts at room temperature.
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: August 23, 2005
    Assignee: Warner-Lambert Company
    Inventors: Hubert Barth, Klaus Steiner, Simon Schneider, Ulrich Bayer, Manfred Westermayer, Ulrike Wolfsperger, Hans-Jürgen Betche
  • Preparation of quinapril hydrochloride
    Patent number: 6858735
    Abstract: Methods and materials for preparing quinapril, its pharmaceutically acceptable salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric acid ethyl ester with (3S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tert-butyl ester to yield quinapril tert-butyl ester, which is subsequently reacted with an acid to yield quinapril or an acid addition salt of quinapril.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: February 22, 2005
    Assignee: Warner-Lambert Company LLC
    Inventor: Sandra Marie Jennings
  • Non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation
    Patent number: 6855849
    Abstract: Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: February 15, 2005
    Assignee: Warner-Lambert Company
    Inventors: Garrett Stewart Hoge, II, Om Prakash Goel
  • Process for preparing single enantiomers of 5,5,5,5?,5?,5?-hexafluoroleucine and protected analogs
    Patent number: 6787664
    Abstract: A process for synthesizing L and D-5,5,5,5′,5′,5′-hexafluoroleucine and protected analogs is disclosed. These compounds have utility in the preparation of fluorous peptides and proteins, which display interesting and unusual properties including strong self-association and an affinity for lipid bilayers.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: September 7, 2004
    Assignees: Warner-Lambert Company LLC, The Regents of the University of Michigan
    Inventors: James T. Anderson, Edward Neil Marsh, Peter Laurence Toogood
  • Method for arylating aza-heterocycles with activated aromatic compounds in the presence of caesium carbonate
    Patent number: 6774242
    Abstract: The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of further catalysts at room temperature.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: August 10, 2004
    Assignee: Goedecke GmbH
    Inventors: Hubert Barth, Klaus Steiner, Simon Schneider, Ulrich Bayer, Manfred Westermayer, Ulrike Wolfsperger, Hans-Jürgen Betche
  • Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts
    Patent number: 6750171
    Abstract: P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: June 15, 2004
    Assignee: Warner-Lambert Company LLC
    Inventors: Garrett Stewart Hoge, II, Om Prakash Goel
  • Method for producing symmetrical and asymmetrical carbonates
    Patent number: 6740768
    Abstract: Process for the preparation of symmetrical and asymmetrical carbonates of the general formula I by reaction of alcohols of the general formula II and alkyl or aryl halides of the general formula III, R—OH  II R′—HAL  III with carbon dioxide and caesium carbonate at room temperature in dipolar aprotic solvents.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: May 25, 2004
    Assignee: Goedecke GmbH
    Inventors: Hubert Barth, Klaus Steiner, Simon Schneider, Ulrich Bayer, Manfred Westermayer, Ulrike Wolfsperger