Abstract: Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
Type:
Grant
Filed:
February 27, 2002
Date of Patent:
February 10, 2004
Assignee:
Warner-Lambert Company LLC
Inventors:
Garrett Stewart Hoge, II, Om Prakash Goel
Abstract: A novel solid pharmaceutical dispersion that improves the bioavailability of poorly water soluble drugs is produced by combining the drug with a polymer carrier such as polyvinylpyrrolidone. The drug is combined with the carrier without the need for using organic solvents or melting temperatures (fusion) through the use of a transition compound such as polyethylene glycol which partially solubilizes the drug and/or plasticizes the polymer.
Type:
Grant
Filed:
March 28, 1994
Date of Patent:
January 13, 2004
Assignee:
Warner-Lambert Company
Inventors:
Isaac Ghebre-Sellassie, Robert Reisch, Jr., Riten Parikh, Mahdi B. Fawzi, Russell U. Nesbitt
Abstract: The invention relates to a method of producing heterocyclic carbamates of the general formula (I) by reacting aza-heterocyclic compounds with alkyl- or aryl-halides in the presence of carbon dioxide and alkali carbonate, and to new compounds of the general formula (I).
Type:
Grant
Filed:
July 6, 2001
Date of Patent:
May 20, 2003
Assignee:
Warner-Lambert Company LLC
Inventors:
Hubert Barth, Klaus Steiner, Simon Schneider, Ulrich Bayer, Manfred Westermayer, Ulrike Wolfsperger, Hans-Jürgen Betche
Abstract: An abutment for securing a dental prosthesis to an implant fixture is disclosed. The abutment includes a base and an attachable coping. The attachable coping carries the dental prosthesis and is mounted on the base of the abutment using a ball-and-socket joint, which permits the dental prosthesis to be easily and accurately aligned with adjacent teeth, implant fixtures or other prostheses. A connector inserted through an aperture in the base of the abutment secures the abutment and the prosthesis to the implant fixture.
Abstract: A single pass, continuous, automated system for producing a pharmaceutical granulation includes multiple feeders to feed powders and liquids, a twin screw processor to granulate, a radio frequency or microwave based drying apparatus to dry the granulation, and at least one mill to process the dried granulation to desired particle sizes. The system incorporates means for monitoring key process parameters on-line, all of which are controlled by a controller provided with feedback at each component of the system. The granulation produced can be compressed into a tablet or incorporated into a capsule, both having a uniform distribution of the active ingredient. The system produces product having consistent properties even when production is scaled up for manufacture of the tablet in commercial volume.
Type:
Grant
Filed:
May 22, 2000
Date of Patent:
December 31, 2002
Assignee:
Warner-Lambert Company
Inventors:
Isaac Ghebre-Sellassie, Matthew J. Mollan, Jr., Nitin Pathak, Mayur Lodaya, Mebrahtu Fessehaie