Abstract: Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.

Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.

Abstract: There is provided a radio-frequency communication device that can sufficiently eliminate a leakage signal from a transmission side included in a received signal. The communication device includes a cancel amplitude controlling unit 62 selectively suppressing supply of a cancel signal to a cancel signal synthesizing unit 52, a received-signal terminating unit 50 selectively terminating a received-signal input terminal 64i, a signal strength detecting unit 78 detecting a signal strength, a memory unit 82 storing a signal strength detected by the signal strength detecting unit 78, a signal strength comparing unit 80 comparing a plurality kinds of signal strengths read out from the memory unit 82, and a cancel signal controlling unit 72 controlling an amplitude and/or a phase of the cancel signal based on a result of the comparison by the signal strength comparing unit 80.

Abstract: In a system and method for processing a form comprising a plurality of entry markings, an area-array image sensor may capture an image of the form in free-space without requiring relative movement of the sensor and the form. A processor may interpret the captured image to determine at least a first entry selection based, at least in part, on the position of at least one of the plurality of entry markings with respect to at least one other marking in the image.

Abstract: A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap assembly containing a cap and an absorbent material is removably attached to the plunger.

Abstract: A liquid delivery apparatus is provided for depositing liquid materials onto prescribed areas. The apparatus includes a sensing and delivery pin and a photo sensor. The apparatus is sized to deliver a droplet of liquid material to the surface of a target area without coming into contact with the target surface. The apparatus is also capable of drawing geometric features, such as lines and grids of liquid material. The photo sensor measures the intensity of light during a processing cycle. Measured reflected-light intensity can be compared in real-time to a reference curve which is based on test process cycles representing the light intensity expected when the process proceeds in the preferred fashion to produce a normal spot having an expected droplet size. The light intensity measurements can also be fitted with a mathematical function such as an asymmetric double sigmoidal curve.

Abstract: The present invention relates to peptide nucleic acid (PNA) probes, PNA probe sets and methods for the analysis of certain Staphylococcus species optionally present in a sample. The invention further relates to diagnostic kits comprising such PNA probes or PNA probe sets.

Abstract: Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation time. The methods comprise ionizing the hormones and analyzing the hormones by mass spectrometry. In addition, methods, systems and kits for the simultaneous or sequential analysis of free thyroxine (FT4) hormone and free-triiodothyronine (FT3) is disclosed comprising ionization of the FT4 and FT3 hormone in the negative mode using an electrospray source.

Abstract: A break-open single-dose sealed package having: a first sheet of semi-rigid plastic material; a second sheet of flexible plastic material set on top of and welded to the first sheet of semi-rigid plastic material to define a sealed pocket that contains a dose of a product; and an incision made in the first sheet of semi-rigid plastic material for guiding controlled breaking of the first sheet along the incision so as to bring about formation, through the first sheet, of an opening for exit of the product; the incision has along its own length a variable depth in order to determine a progressive breaking of the first sheet along the incision.

Abstract: Embodiments relate to Rifaximin polymorphic, salt, and hydrate forms, methods of producing polymorphic forms and to their use in medicinal preparations and to therapeutic methods using them.

Abstract: This invention relates to novel compounds that are substituted oxazolidinones derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel oxazolidinones compounds that are derivatives of rivaroxaban. The invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and condition that are beneficially treated by administering a selective inhibitor of factor Xa, such as rivaroxaban.

Abstract: A venting liner is connectable in fluid communication between a closure and an interior of a device for venting gas from the interior into the ambient atmosphere. The venting liner has an outer foam layer defining an inner surface and an outer surface, a plurality of fluid-flow apertures spaced relative to each other, extending between the inner and outer surfaces, and forming substantially vertical fluid-flow paths through the outer layer, and a plurality of relatively raised portions extending outwardly relative to the outer surface adjacent to respective fluid-flow apertures. A plurality of the relatively raised portions are engageable with the closure, define a substantially horizontal, tortuous fluid-flow path between the outer surface and the closure, and are in fluid communication with a plurality of fluid-flow apertures for venting gas flowing substantially vertically through the fluid-flow aperture(s) and, in turn, substantially horizontally between the outer surface and the closure.

Abstract: A dispenser is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials that may react upon exposure to air, such as glue. Means are provided in the dispenser to effect controlled delivery of a pre-determined amount of the substance contained in the dispenser. A one-way valve is provided to hermetically seal the portion of the dispenser containing the substance to be dispensed.

Abstract: In a reception management apparatus, when a print button is operated after scheduled visitor information is selected, a badge ID representing print number is assigned to the selected scheduled visitor information and thereby print data of an entry pass associated with the scheduled visitor information is created and output to a printer. At the same time, the badge ID is assigned to and displayed in the scheduled visitor information in the appointment list display window. Further, when a shared button is operated after the scheduled visitor information is selected, the badge ID representing print number is assigned to the selected scheduled visitor information and thereby print data of the entry pass associated with the scheduled visitor information is created and output to the printer. At the same time, the personal information corresponding to the scheduled visitor information is stored in the entry-permitted list as entry-permitted visitor information.

Abstract: A system for dispensing with a valve-less block including internal air passages coupled with an air source and internal dispensing passages coupled with a flow channel. The flow channel is disposed external to the block and couples with a fluid source. The dispensing passages are further configured in fluid communication with the air passages and place the flow channels in fluid communication with the air passages. A port is defined in the block to dispense fluid from the block. At least one sensor is coupled with each flow channel and indicates the presence of at least one of air and fluid in the flow channel. The detection of air or fluid ensures a location of a flow front of a fluid residing in the flow channel, and ensures the presence of an air gap that serves as a check valve to prevent mixing of fluids and to prevent backflow.

Abstract: Disclosed is a holding device (1) for a poster-shaped information carrier, comprising two board segments (2) for receiving the information carrier therebetween, at least one of the board segments (2) being transparent in order for the information support to be visible. A base (3) is used for inserting the two board segments (2). A means (4) is provided for leaving a gap between the two board segments (2) for receiving the information carrier. Said means (4) for leaving the gap (20) between the two board segments (2) is a web which is arranged within the base (3) and extends between the board segments (2), and/or a spacing element (4) that lies between the board segments (2).

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: A system and methods for generating 3D images (24) from 2D bioluminescent images (22) and visualizing tumor locations are provided. A plurality of 2D bioluminescent images of a subject are acquired during a complete revolution of an imaging system about a subject, using any suitable bioluminescent imaging system. After imaging, the 2D images are registered (20) according to the rotation axis to align each image and to compensate for differences between adjacent images. After registration (20), corresponding features are identified between consecutive sets of 2D image (22). For each corresponding feature identified in each set of 2D images an orthographic projection model (24) is applied, such that rays are projected through each point in the feature. The intersection point of the rays are plotted in a 3D image of a tumor is generated. The 3D image can be registered with a reference image of the subject, so that the shape and location of the tumor can be precisely visualized with respect to the subject.