Abstract: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which the yjgF ORF or the nucleotide sequence which codes for it are attenuated, in particular eliminated, b) concentration of the L-amino acid in the medium or in the cells of the bacteria, and optionally c) isolation of the L-amino acid.

Abstract: The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a cofactor-dependent enzymatic transformation of an organic compound and an enzymatic regeneration of the cofactor, wherein the reaction system operates in aqueous solution with an amount of substrate above the solubility limit thereof. In the preferred embodiments, an alcohol dehydrogenase is the cofactor-dependent enzyme, and the regeneration of the cofactor (e.g. NADH or NADPH) is acheved by means of formate dehydrogenase.

Abstract: The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.

Abstract: The present invention is directed to a process for preparing ?-amino-?-hydroxycarboxamides. The process works with epoxycarboxamides of the formula 2 which are reacted with ammonia or other amines.

Abstract: The invention provides a process for the removal of polysulfanes from gas streams formed during H2S synthesis.

Abstract: The invention concerns coated sodium percarbonate granules comprising a core produced by fluidized bed spray granulation, containing sodium percarbonate as its main component, an inner coating layer containing an organic, hydrate-forming salt as its main component, and an outer coating layer containing as its main component at least one surfactant containing in the molecule one or more sulfate or sulfonate groups in the form of an alkali metal, alkaline-earth metal or ammonium salt. The invention also concerns a process for the production of the granules, the use of the granules in bleaching and cleaning agents, and bleaching and cleaning agents containing the granules. The sodium percarbonate granules according to the invention display improved storage stability combined with high internal stability and a high active oxygen content.

Abstract: The invention relates to a process for the preparation of L-amino acids by the fermentation of recombinant microorganisms of the family Enterobacteriaceae. The microorganisms produce the desired L-amino acid and overexpress the E. coli or S. typhimurium yibD gene encoding the putative glycosyl transferase enzyme. The microorganisms are cultivated in a medium under conditions in which the desired L-amino acid is enriched in the medium or in the cells. The amino acid is then isolated, optionally with constituents of the fermentation broth, and/or all or part (?0 to 100%) of the biomass.

Abstract: Laundry detergents comprising a fabric softening effective amount of an alkoxypropylamine of structures (I) or (II) R1—O—(CH2)3—NHR2??(I) R1—O—(CH2)3—NR32(CH3)+X???(II) wherein R1 is a C8-20 alkyl group, R2 is hydrogen or (CH2)3NH2, R3 is CH3 or CH2CH2OH and X? is an anion, or of a salt of a compound of structure (I), provide simultaneous cleaning and softening of fabrics without the need for an additional fabric softener.

Abstract: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family in which the ytfQ-ORF is overexpressed.

Abstract: The present invention is directed to immunogenic conjugates comprised of a polymer, preferably a polysaccharide, with a covalently attached antigen and an agent for boosting a patient's immune response. The conjugates may be used in vaccines for a wide range of diseases.

Abstract: The present invention is directed to a process for the isolation of tris(2,3-dibromopropyl)isocyanurate. The process uses an adsorbent which promotes easy conversion into a solid form of TDPI. The invention also includes to the solid TDPI product prepared in this way and its use in providing flame retardancy to plastics.

Abstract: The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain these alleles.

Abstract: The present invention relates to a process for preparing mercaptoorganyl(alkoxysilanes), by hydrogenating bis(alkoxy-silylorganyl) polysulphides with hydrogen in the presence of at least one alcohol and a doped metal catalyst. The doped metal catalyst comprises at least one substance from the group consisting of iron, iron compound, nickel, nickel compound, palladium, palladium compound, osmium, osmium compound, ruthenium, ruthenium compound, rhodium, rhodium compound, iridium and iridium compound plus at least one doping component.

Abstract: The present invention relates to the preparation of ?-hydroxy ketones of the general formula I. In particular, the invention relates to novel imidazolinium carboxylate adducts and to a novel process for using catalytic amounts of imidazolium and imidazolinium carboxylate adducts in the acyloin reaction of aldehydes to prepare hydroxy ketones of the general formula I, where R and R? are the same or different and are each H or a straight-chain or branched and optionally substituted C1-C12-alkyl radical, and R??H3CSCH2CH2, t-butyl, n-butyl, sec-butyl, n-propyl, i-propyl, an optionally heteroatom-substituted C6-C18-aryl, heteroaryl, C6-C18-arylalkyl, especially phenylmethyl, where phenyl may again be heteroatom-substituted, or heteroalkyl.

Abstract: The invention relates to a Rhodococcus polynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein P15K which activates this enzyme and of a cobalt transporter, to transformed microorganisms in which the nucleotide sequences encoding these proteins are present in increased quantity, and to the use of the transformed microorganisms for preparing amides from nitriles.

Abstract: The present invention is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gp120 on the HIV viral surface may be increased by sulfating tyrosine residues. In addition, the invention is directed to a method for increasing the affinity of antibodies for their antigens by sulfating tyrosine residues in the antibody amino acid chain.

Abstract: Process for the extraction of substances from at least one silane-modified oxidic or silicatic filler, wherein at least one gas compressed by means of pressure and/or temperature is employed as the extraction agent and the compressed gas is led in the radial direction through the filler in the pressure container and/or the substances extracted from the silane-modified filler are removed from the compressed gas with a suitable sorbent. A device for carrying out the process is furthermore described, wherein this comprises at least one pressure container having at least one internal container, sieve or insert for accommodation of the fillers which is permeable to gas and at least one gas feed and gas removal in the bulk bed of filler, and has a radially designed gas feed or gas removal from the bulk bed of filler.

Abstract: The invention relates to liquid detergent and cleaning agent compositions of high storage stability. They comprise a liquid medium with a water content of up to 15 wt. % and particulate coating bleaching agents suspended therein. The bleaching agent has a dissolving time of at least 5 minutes and a coating of at least two layers: The innermost layer comprises one or more hydrate-forming inorganic salts as the main component(s), and an outer layer, which makes up 0.2 to 5 wt. % of the coated bleaching agent, comprises alkali metal silicate(s) with a modulus of SiO2 to M2O (M=alkali metal) of greater than 2.5 as the main component(s). Preferred compositions comprise sodium percarbonate with an innermost layer of substantially sodium sulfate and an outermost layer of substantially 0.5 to 1.5 wt. % sodium silicate (modulus 3.2 to 4.2) as the bleaching agent.

Abstract: The present invention is directed to a therapeutic composition in which human PDGF is bound directly to peptides that self assemble into a biologically compatible gel. When implanted in a patient's body, the composition provides for the slow, sustained release of PDGF. The composition will be especially useful in treating patients who have undergone a myocardial infarction.

Abstract: The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts.