Patents Represented by Attorney, Agent or Law Firm Michael A. Sanzo
  • Alleles of the mqo gene from coryneform bacteria
    Patent number: 7214526
    Abstract: The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: May 8, 2007
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Stephan Hans, Natalie Schischka, Georg Thierbach
  • Enterobacteriaceae strains over-expressing the yfiD gene for the fermentative production of L-amino acids
    Patent number: 7211415
    Abstract: The present invention relates to a process for the production of L-amino acids by fermentation of recombinant microorganisms of the Enterobacteriaceae family, wherein a) the yfiD ORF and/or the pflB gene or nucleotide sequences coding for the gene products are overexpressed in the microorganisms producing the desired L-amino acid, and the microorganisms are cultured in a medium under conditions in which the desired L-amino acid is enriched in the medium or in the cells; and b) the desired L-amino acid is isolated, in a manner such that constituents of the fermentation broth and/or the biomass in its entirety or in portions (>0 to 100%) either remain in the isolated product or are completely removed.
    Type: Grant
    Filed: April 5, 2004
    Date of Patent: May 1, 2007
    Assignee: Degussa AG
    Inventors: Mechthild Rieping, Mike Farwick
  • Method for altering the body temperature of a patient using a nebulized mist
    Patent number: 7201163
    Abstract: Methods for changing the body temperature of a patient by having them breathe a mist created by nebulizer. The temperature of the mist is adjusted using a heat exchanger. The methods may be used to either cool or warm patients for a variety of clinical reasons. In addition, the invention includes a device (Thermomist) that can be used for generating a mist that can be administered to patients.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: April 10, 2007
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Yandong Jiang, Massimo Ferrigno
  • Process for the production of hydrogen peroxide
    Patent number: 7195748
    Abstract: The invention relates to a process for the production of hydrogen peroxide by the anthraquinone process, comprising a hydrogenation stage, an oxidation stage and an extraction stage. According to the invention, catalytic hydrogenation of anthraquinone derivatives dissolved in a working solution is carried out in the presence of added molecular oxygen. Per mol hydrogen, 0.1 to 10 mmol oxygen is preferably introduced into the hydrogenation stage with the hydrogenating gas, in mixture with an inert gas and/or dissolved and/or dispersed in the working solution. This increases the residence time of the catalyst.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: March 27, 2007
    Assignee: Degussa AG
    Inventors: Bernd Jaeger, Thomas Haas, Jürgen Glenneberg, Jürgen Grunert
  • Carbon black granules
    Patent number: 7172652
    Abstract: The present invention is directed to carbon black granules containing a sorbitan triester. In addition, a process for the production of these carbon black granules is described, in which a powdered carbon black or beaded carbon black is beaded with a sorbitan triester. The carbon black granules can be used in polymer blends, lacquers, inks or pigments.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: February 6, 2007
    Assignee: Degussa AG
    Inventors: Heinz Zoch, Norbert Hornick, Alfons Karl, Silke Teike
  • Hypoxia responsive transcription enhancer element from yeast
    Patent number: 6821751
    Abstract: The present invention is directed to DNA elements that enhance cellular gene expression in response to anaerobic growth or the presence of certain inducing agents. The enhancer element may be incorporated into expression vectors and used to increase the production of recombinant proteins.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: November 23, 2004
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Mark Alan Goldberg, Michael Vasconcelles, Yide Jiang
  • G-protein coupled receptor
    Patent number: 6800749
    Abstract: The present invention is directed to a novel neurotensin-like receptor expressed in the central nervous system of humans. The invention encompasses the receptor protein as well as nucleic acids encoding the protein. In addition, the invention is directed to methods and compositions which utilize the receptor.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: October 5, 2004
    Assignee: AstraZeneca Canada Inc.
    Inventors: Sultan Ahmad, Jack Cao, Dajan O'Donnell, Philippe Walker
  • Compound and a novel process for their preparation
    Patent number: 6784210
    Abstract: The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of a phosphine ligand. The compounds synthesized may be used in pharmaceutical preparations for the treatment of a variety of diseases and conditions.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: August 31, 2004
    Assignee: AstraZeneca AB
    Inventors: Keith Fagnou, Mark Lautens
  • Piperazine-containing compounds useful in the treatment of pain
    Patent number: 6784181
    Abstract: The present invention is directed to a compound of general formula (I), wherein R1 is selected from phenyl, pyridinyl, thiophenyl, furanyl, imidazolyl; each phenyl ring and heteroaromatic ring optionally and independently being further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo, as well as their pharmaceutically acceptable salts. The invention includes pharmaceutical compositions comprising these compounds and the use of the compounds in therapy, in particular in the management of pain.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: August 31, 2004
    Assignee: AstraZeneca AB
    Inventors: William Brown, Christopher Walpole, Niklas Plobeck
  • Compounds
    Patent number: 6777561
    Abstract: Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: August 17, 2004
    Assignee: AstraZeneca Canada Inc.
    Inventors: Daniel Delorme, Vlad Gregor, Edward Roberts, Eric Sun
  • Spirooxindole derivatives that act as analgesics
    Patent number: 6774132
    Abstract: The present invention relates to certain spirooxindole derivatives and to pharmaceutically acceptable salts thereof, which exhibit good analgesic properties and are effective in the treatment of chronic pain. The derivatives have the structure of formula I: wherein: Ar is benzene or pyridine; X is NHCO—; —CONH—; or —NH—SO2—; Y is a single bond; and Z is —CH═CHCH2.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: August 10, 2004
    Assignee: AstraZeneca AB
    Inventors: Alf Claesson, Britt-Marie Swahn, Odd-Geir Berge
  • Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain
    Patent number: 6756387
    Abstract: Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, triazolyl and thiazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: June 29, 2004
    Assignee: AstraZeneca AB
    Inventors: William Brown, Christopher Walpole, Zhongyong Wei
  • Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain
    Patent number: 6753335
    Abstract: Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, and triazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: June 22, 2004
    Assignee: AstraZeneca AB
    Inventors: William Brown, Christopher Walpole, Zhongyong Wei
  • Capsular polysaccharides from enterococci
    Patent number: 6722062
    Abstract: The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In addition, the invention is directed to the antigens produced by this purification method and to vaccines which utilize such antigens.
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: April 20, 2004
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Gerald B. Pier, Johannes Huebner, Ying Wang, Lawrence Madoff
  • Treatment of substance P-related disorders
    Patent number: 6709651
    Abstract: The present invention is directed to methods of treating a wide variety of diseases, disorders and conditions characterized by excessive activity of substance P. The treatment involves administering peptidases that recognize and selectively cleave polypeptides at Xaa-Pro sequences.
    Type: Grant
    Filed: July 3, 2001
    Date of Patent: March 23, 2004
    Assignee: B.M.R.A. Corporation B.V.
    Inventors: Eric Grouzmann, Jean-Silvain Lacroix, Michel Monod
  • Treatment of damaged tissue using agents that modulate the activity of alpha-smooth muscle actin
    Patent number: 6710025
    Abstract: The present invention is directed to therapeutic methods that are based upon an ability to modulate cellular contraction. This is accomplished by administering agents that either inhibit or induce the activity of alpha-smooth muscle actin.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: March 23, 2004
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Myron Spector
  • Compounds with analgesic effect
    Patent number: 6710179
    Abstract: Compounds of general formula (I) wherein m is 0 or 1, and n is 1 or 2; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: March 23, 2004
    Assignee: AstraZeneca Canada Inc.
    Inventors: Benjamin Pelcman, Edward Roberts
  • Compounds useful in pain management
    Patent number: 6703483
    Abstract: Compounds of the formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, particular in the management of pain, and more particularly in the management of pain during labor.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: March 9, 2004
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Peter Schiller
  • System for co-culturing bacteria and eukaryotic cells
    Patent number: 6696287
    Abstract: The present invention is directed to an apparatus that can be used for co-culturing bacteria and eukaryotic cells. The apparatus allows the bacteria to be grown under steady state conditions and then perfused over the eukaryotic cells. The invention also includes a variety of methods for studying the attachment and invasion of host eukaryotic cells by bacteria.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: February 24, 2004
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Lawrence C. Paoletti, Gennady Malin
  • G protein-coupled receptors from the rat and human
    Patent number: 6696257
    Abstract: The present invention is directed to novel G protein-coupled receptors that are found predominantly in the dorsal root ganglia. The invention encompasses both the receptor proteins as well as nucleic acids encoding the proteins. In addition, the present invention is directed to methods and compositions which utilize the receptors.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: February 24, 2004
    Assignee: National Research Council of Canada
    Inventors: Sultan Ahmad, Denis Banville, Yves Fortin, Paola Lembo, Dajan O'Donnell, Shi-Hsiang Shen