Abstract: The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1.
Type:
Grant
Filed:
June 26, 2008
Date of Patent:
September 25, 2012
Assignee:
4SC AG
Inventors:
Thomas Stengel, Mathias Schmidt, Steffen Weinbrenner, Alexander Weber, Petra Gimmnich, Volker Gekeler, Thomas Beckers, Astrid Zimmermann, Thomas Maier, Beate Schmidt, Florian Dehmel
Abstract: Disclosed are novel liquid-crystal compounds, processes and intermediates for the preparation thereof, the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, and to LC media and LC displays containing the same.
Type:
Grant
Filed:
January 15, 2010
Date of Patent:
September 25, 2012
Assignee:
Merck Patent Gesellschaft Mit Beschrankter Haftung
Inventors:
Axel Jansen, Detlef Pauluth, Bernd Fiebranz, Bernhard Rieger
Abstract: The present invention relates to pearlescent pigments based on glass flakes which are distinguished by the fact that they have the following layer structure: A) optionally a layer of SiO2, B) a high-refractive-index coating have a refractive-index n>1.8 which essentially consists of TiO2, C) a low-refractive-index layer comprising SiO2 and/or Al2O3 and optionally D) an outer protective layer, and to the use thereof in paints, coatings, automobile paints, powder coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, paper, in toners for electrophotographic printing processes, in seed, in greenhouse sheeting and tarpaulins, as absorbers in the laser marking of paper and plastics, as absorbers for the laser welding of plastics, in cosmetic formulations, for the preparation of pigment pastes with water, organic and/or aqueous solvents, for the preparation of pigment compositions and dry preparations.
Type:
Grant
Filed:
August 10, 2005
Date of Patent:
September 18, 2012
Assignee:
Merck Patent GmbH
Inventors:
Sabine Melson, Marc Entenmann, Marita Jekel, Marcus Mathias
Abstract: The present invention relates to the use of compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, for the development of UV-A or UV-B protection during use, to corresponding novel compounds and compositions, and to corresponding processes for the preparation of compounds and compositions.
Abstract: The present invention relates to dielectrically positive liquid-crystalline media comprising one or more compounds of the formula I in which the parameters have the meaning indicated in the specification, and optionally one or more compounds selected from the group of the compounds of the formulae II and III in which the parameters have the meaning indicated in the specification, and optionally one or more compounds of the formula IV in which the parameters have the meaning indicated in the specification, and to liquid-crystal displays containing these media, especially to active-matrix displays and in particular to TN, IPS and FFS displays.
Type:
Grant
Filed:
January 27, 2009
Date of Patent:
September 18, 2012
Assignee:
Merck Patent GmbH
Inventors:
Markus Czanta, Harald Hirschmann, Michael Wittek, Volker Reiffenrath, Renate Bender, Christian Hock, Brigitte Schuler
Abstract: The present invention relates to salts having thiouronium or uronium cations, to processes for the preparation thereof, and to the use thereof as ionic liquids.
Type:
Grant
Filed:
May 28, 2004
Date of Patent:
September 18, 2012
Assignee:
Merl Patent GmbH
Inventors:
Nikolai (Myloka) Ignatyev, Urs Welz-Biermann, German Bissky, Helge Willner, Andriy Kucheryna
Abstract: The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula I as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their use for the manufacture of a pharmaceutical composition and new tetrahydro- and dihydroquinazolinones.
Abstract: The present application is directed to novel P2X7R antagonists that are N-indol-3-yl-acetamide and N-azaindol-3-yl-acetamide compounds, pharmaceutical compositions comprising the same and their use for the prophylactic or therapeutic treatment of diseases mediated by P2X7R activity.
Abstract: The invention relates to a snowboard binding with a sole-plate which is to be fastened on the surface of a snowboard and to which, firstly, an instep element is fastened or coupled, which instep element can be adjusted between a clamping position and a release position and by means of which the upper side of a shoe, which can be accommodated in the snowboard binding can be partially embraced, and to which, secondly, a leg support is pivotably coupled, which leg support can be pivoted between a rear entry position and a front travelling position with control means provided by means of which a pivoting movement of the leg support into the entry position is coupled at least in some sections to an adjustment movement of the instep element from the clamping position into the release position.
Type:
Grant
Filed:
October 23, 2007
Date of Patent:
September 18, 2012
Assignee:
SAM Sport and Marketing AG
Inventors:
Thomas Krenn, Andreas Janisch, Roland Kittag
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the ?7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Type:
Grant
Filed:
December 4, 2009
Date of Patent:
September 11, 2012
Assignee:
Memory Pharmaceuticals Corporation
Inventors:
Wenge Xie, Brian Herbert, Richard A. Schumacher, Truc Minh Nguyen, Jianguo Ma, Carla Maria Gauss, Ashok Tehim
Abstract: In carton packaging having an outer folding carton and an inner folding carton which surrounds a film internal container, the inner folding carton is adhesively bonded by means of one of its carton body walls (14) to an adjacent carton body wall (6) of the outer folding carton. The outer folding carton and the inner folding carton surround the film internal container essentially completely. The film internal container consists of a flexible film internal bag provided with a withdrawal closure. The carton body walls (13, 14, 15, 16) of the inner folding carton are connected to one another in a foldable manner at the body edges (17, 18, 19, 20) via carton bridges, each bridging an edge slot. The lid flaps of the inner folding carton are angled in the finished carton packaging. The inner folding carton and the outer folding carton consist of a joint carton blank or each consist of a separate carton blank or each consist of a plurality of carton blanks.
Type:
Grant
Filed:
June 17, 2008
Date of Patent:
September 11, 2012
Assignees:
Merck Patent GmbH, STI Gustav Stabernack GmbH
Inventors:
Roland Raupach, Bettina Straub-Jubb, Thomas Ritz
Abstract: The instant invention relates to dielectrically positive nematic media comprising one, two or more compounds of formula I one or more compounds selected from the group of formulae II and III and one or more compounds selected from the group of formulae IV and V wherein the parameters are as defined in claim 1 with the proviso that the media comprise one or more compounds of formula III, wherein n and o both are 1 and all rings are 1,4-phenylene, which independently of each other optionally are fluorinated once or twice, and/or one or more compounds of formula V, wherein q is 2, as well as to liquid crystal displays comprising these media, especially to TN-displays and in particular to active matrix displays.
Type:
Grant
Filed:
March 11, 2009
Date of Patent:
September 11, 2012
Assignee:
Merck Patent Gesellschaft mit beschrankter Haftung
Inventors:
Martin (Kelun) Shu, Carol (Yi-Hsuan) Lin, Fred (Jer-Lin) Chen, Mark Verrall
Abstract: The present invention relates to the preparation and use of variants of the group 1 allergens of the Poaceae (sweet grasses) which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially maintained reactivity with T-lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventive immunotherapy of grass pollen allergies.
Type:
Grant
Filed:
July 11, 2005
Date of Patent:
September 11, 2012
Assignee:
Merck Patent GmbH
Inventors:
Helmut Fiebig, Martin Wald, Andreas Nandy, Helga Kahlert, Bernahrd Weber, Oliver Cromwell
Abstract: An object of the invention is to provide a TFT substrate and a method for producing a TFT substrate which is capable of drastically reducing the production cost by decreasing the number of steps in the production process and improving production yield. A TFT substrate comprises: a substrate; a first oxide layer formed above the substrate; a second oxide layer formed above the first oxide layer with a channel part interposed therebetween; a gate insulating film formed above the substrate, the first oxide layer and the second oxide layer; a gate electrode and a gate wire formed above the gate insulating film.
Type:
Grant
Filed:
November 30, 2006
Date of Patent:
September 11, 2012
Assignee:
Idemitsu Kosan Co., Ltd.
Inventors:
Kazuyoshi Inoue, Koki Yano, Nobuo Tanaka, Tokie Tanaka, legal representative
Abstract: The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
Type:
Grant
Filed:
October 17, 2007
Date of Patent:
September 11, 2012
Assignee:
Bayer Schering Pharma AG
Inventors:
Johannes Platzek, Heiko Schirmer, Hanns-Joachim Weinmann, Bernd Misselwitz, Ludwig Zorn
Abstract: The invention relates to a plastic film, at least one side of which is provided with a surface structure comprising parallel rows of elevations (a). Said elevations (a) are interconnected by means of webs (b) that are at least 10 percent lower than the elevations (a). The inventive films can be used for producing laminated glass.
Abstract: To provide functional paste with etching activity and good electrical properties. Functional paste comprising a metal powder, an etching agent, a binder and an organic solvent.
Type:
Grant
Filed:
October 22, 2004
Date of Patent:
September 4, 2012
Assignee:
Merck Patent GmbH
Inventors:
Sylke Klein, Armin Kuebelbeck, Werner Stockum, Jun Nakanowatari, Kiyohiko Kawamoto, Katsumi Tanino
Abstract: Novel compounds of the formula I, in which X, Y, R, R?, R1, R1?, R1?, R2, R2?, R2?, R3, R3?, R4, R4? and n have the meanings indicated in Patent Claim 1, are suitable as antidiabetics
Type:
Grant
Filed:
May 25, 2007
Date of Patent:
September 4, 2012
Assignee:
Merck Patent GmbH
Inventors:
Werner Mederski, Norbert Beier, Bertram Cezanne, Rolf Gericke, Markus Klein, Christos Tsaklakidis
Abstract: The invention relates to a catalyst that comes in the form of grains, each grain consisting of a core covered by at least one external layer, the core consisting of an acidic porous solid and having a size of between 0.1 micron and 0.4 millimeter, in which the external layer has a uniform thickness with a uniformity criterion C, which is less than 0.30, whereby said uniformity criterion C is defined as being equal to an average, on a number N of catalyst grain samples, of the ratio of the difference between the maximum thickness, Eimax, of the external layer and the minimum thickness, Eimin, of this same layer to the average of these two thicknesses Eimax and Eimin.
Type:
Grant
Filed:
January 13, 2005
Date of Patent:
September 4, 2012
Assignee:
IFP Energies nouvelles
Inventors:
Younes Bouizi, Valentin Valtchev, Loiec Rouleau, Nicolas Bats, Laurent Simon
Abstract: A process for partial dehydration of a gas by contact with a solvent that can be regenerated by: a) A stage for absorption of H2O by contact of the gas to be treated and regenerated solvent producing a dehydrated gas effluent and a liquid solvent effluent that is charged with H2O and absorbed gas, b) A stage for cooling the solvent charged with H2O at ambient temperature, c) A stage for separation by segregation during which liquid H2O and the solvent are separated at ambient temperature, d) A stage in which the regenerated solvent that is obtained at the end of stage c) is heated, e) A stage in which the regenerated and heated solvent that is obtained at the end of stage d) is recycled to the absorption stage a).