Patents Represented by Attorney, Agent or Law Firm Mishrilal Jain
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Patent number: 6194193Abstract: A liquid and dry formulation suitable for use in enhancing plant growth which includes a plurality of Bacillus and Paenibacillus strains at least one of which function to produce phytohormones in a non-toxic form. The formulation also includes a phytohormone component and a phytohormone precursor to potentiate roots for colonization by the inoculated strains, as well as a low level blend of nutrients and micronutrients for optimal plant development.Type: GrantFiled: December 11, 1998Date of Patent: February 27, 2001Inventors: David J. Drahos, Donald J. Miller
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Patent number: 5126132Abstract: A new immunotherapeutic method of treating cancer with a combination of tumor infiltrating lymphocytes and IL-2 has been described.Type: GrantFiled: August 21, 1989Date of Patent: June 30, 1992Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: Steven A. Rosenberg
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Patent number: 5104792Abstract: A modification of the PCR technique is described which allows fragments of RNA or DNA to be amplified without prior knowledge of their sequence. The technique can be used to amplify viral nucleic acids present in small amounts in clinical material allowing, for example, the diagnosis of a particular virus infection or the discovery of new viruses.Type: GrantFiled: December 21, 1989Date of Patent: April 14, 1992Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Jonathan Silver, Stephen Feinstone
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Patent number: 5082927Abstract: The present invention provides a chimeric protein IL4-PE40 which selectively kills IL4 receptor bearing cells. A mutant form of the protein is also provided.Type: GrantFiled: May 12, 1989Date of Patent: January 21, 1992Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Ira Pastan, David FitzGerald, Masato Ogata
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Patent number: 5081226Abstract: This invention relates to the identification of short peptide segments of AIDS virus proteins which elicit T cellular immunity, and to a method of inducing cellular immunity to native proteins of the AIDS virus by immunization with short synthetic peptides. Five potential peptides have been identified by searching for regions which can fold as a maximally amphipathic helix. These may be useful to include in either a synthetic peptide- or recombinant fragment- based vaccine.Type: GrantFiled: February 28, 1990Date of Patent: January 14, 1992Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Jay A. Berzofsky, Charles DeLisi, Hanah Margalit, James L. Cornette, Kemp B. Cease, Cecilia S. Ouyang
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Patent number: 5073486Abstract: An assay for detecting the presence of Mycoplasma fermentans is disclosed, along with a diagnostic kit that uses the assay. The presence of Mycoplasma fermentans is indicated by the presence of the restriction endonuclease MfeI. This endonuclease recognizes the sequence CAATTG and cleaves between the C and the first A.Type: GrantFiled: April 4, 1990Date of Patent: December 17, 1991Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Warren J. Leonard, Julie B. Wolf, Nancy F. Halden
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Patent number: 5063053Abstract: The isolation and purification of a newly discovered gene of the AIDS virus, HTLV-III, which encodes a portein which is immunogenic and recognized by sera of some HTLV-III seropositive people. Furthermore, the gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3' end which distinguishes molecular clones of the HTLV-IIIB cell line from viral genomes of related viruses.Type: GrantFiled: July 25, 1990Date of Patent: November 5, 1991Assignee: The United States of America as represented by the Department of Health & Human ServicesInventors: Flossie Wong-Stal, Pranab K. Chanda, John Ghrayeb
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Patent number: 5049662Abstract: A new NM23 gene and its relationship with metastatic potential of tumor cells is described.Type: GrantFiled: October 13, 1987Date of Patent: September 17, 1991Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Patricia S. Steeg, Lance A. Liotta, Mark E. Sobel, Generoso Bevilacqua
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Patent number: 5028425Abstract: A purified peptide which induces proliferation or activation of cytotoxic T cells specifically against circumsporozoite protein of P. falciparum is described. The peptide has an amino acid sequence KPKDELDYENDIEKKICKMEKCS in single letter amino acid code.Type: GrantFiled: July 7, 1988Date of Patent: July 2, 1991Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Michael F. Good, Sanjai Kumar, Jay A. Berzofsky, Louis H. Miller
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Patent number: 4994370Abstract: A modification of the polymerase chain reaction (PCR) technique is described. The method allows the amplification of regions of DNA flanking a single region of known sequence, in contrast to standard PCR which requires two regions of known sequence at opposite ends of the fragment to be amplified. Various advantages of the new method are described.Type: GrantFiled: January 3, 1989Date of Patent: February 19, 1991Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Jonathan Silver, Vijaya R. Keerikatte
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Patent number: 4983314Abstract: A quick, car-cooling composition is provided. The composition consists essentially of:about 5-15% by volume of methanol;about 20% by volume of a propellent;about 0.5% by weight of sodium benzoate;about 0.2% by volume of fragrance;about 0.2% by volume of morpholine; andabout 64.1 to 74.1% of deionized water.When sprayed in rapid, intermittent succession, the composition lowers the temperature in a hot confined space.Type: GrantFiled: March 14, 1990Date of Patent: January 8, 1991Assignee: North American Oil Company, Inc.Inventor: Cal Yudin
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Patent number: 4968601Abstract: A method for diagnosing latent viral infection is described. The method utilizes an agent such as OKT3 to stimulate CD3 receptor complex on T-cell line so that the latent virus harbored in the T cells is expressed and then the virus is identified by standard techniques.Type: GrantFiled: February 9, 1988Date of Patent: November 6, 1990Assignee: The United States of America as represented by the Dept. of Health & Human ServicesInventors: Steven Jacobson, Dale E. McFarlin
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Patent number: 4963497Abstract: The present invention is the isolation and purification of a newly discovered gene of the AIDS virus, HTLV-III, which encodes a protein which is immunogenic and recognized by sera of some HTLV-III seropositive people. Furthermore, the gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3' end which distinguishes molecular clones of the HTLV-III cell line from viral genomes of related viruses (i.e., other HTLV-III isolates, LAV, ARV, etc.).Type: GrantFiled: October 20, 1986Date of Patent: October 16, 1990Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Flossie Wong-Staal, Pranab K. Chanda, John Ghrayeb
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Patent number: 4961811Abstract: Affixable paper that can be detached substantially non-destructively is disclosed. A non-essential portion of the affixable paper is so attached to a second paper with a moist adhesive in the form of microdots or microlines that after secure attachment, the affixable paper can be removed from the second paper in substantially original condition. The affixable paper may have cut scores to facilitate removal.Type: GrantFiled: December 14, 1988Date of Patent: October 9, 1990Inventor: Rudiger D. Haugwitz
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Patent number: 4942184Abstract: Antineoplastic, water soluble, taxol derivatives and methods for preparing the same are described.Type: GrantFiled: March 7, 1988Date of Patent: July 17, 1990Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Rudiger D. Haugwitz, Leon Zalkow, Jan Glinski, Mathew Suffness, Howard M. Deutsch, Venkatachala Narayanan
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Patent number: 4935367Abstract: A new restriction enzyme, Mfe I, has been discovered. Mfe I recognizes the sequence CAATTG and cuts at the recognition sequence C'AATTG and generates compatible cohesive ends with EcoRI cleaved fragments. Various utilities of the enzyme have been described.Type: GrantFiled: October 21, 1988Date of Patent: June 19, 1990Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Warren J. Leonard, Julie B. Wolf, Nancy F. Halden
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Patent number: 4931393Abstract: The present invention is related to providing a non-infectious molecular clone of a mutant HIV and HIV proteins useful as immunogens and reagents for diagnostic kit.Type: GrantFiled: September 14, 1987Date of Patent: June 5, 1990Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Malcolm A. Martin, Ronald Willey
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Patent number: 4927628Abstract: A new method for producing live, attenuated rotavirus strains suitable for preparing a vaccine is described. It is demonstrated that a naturally attenuated rotavirus recovered from newborns or other individuals whos have undergone asymptomatic infection can be used for immunization or that a virulent rotavirus can be converted into an attenuated strain by substituting the conserved fourth rotavirus gene segments of a naturally attenuated rotavirus in the genome of the virulent rotavirus.Type: GrantFiled: September 21, 1987Date of Patent: May 22, 1990Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Robert M. Chanock, Albert Kapikian, Karen Midthun, Jorge Flores, Mario Gorziglia, Yasutaka Hoshino, Irene Peres-Schael
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Patent number: 4925799Abstract: A plasmid cloning vector containing both transcriptional and translational regulatory sequences derived from the bacteriophage lambda genome was constructed to achieve high level expression of prokaryotic and eukaryotic genes. The system utilizes a plasmid vehicle carrying the strong, regulatable lambda promoter, P.sub.L, and host lysogens into which this vector can be stabily transformed. The lysogen synthesizes sufficient repressor (cI) to control P.sub.L expression and thereby stabilize plasmids which carry such a highly efficient promoter. Use of a temperature sensitive repressor permits simple, rapid induction of P.sub.L transcripts at any given time. Efficient transcription of essentially any coding sequence is assured by providing the phage lambda antitermination factor, N, and a site on the transcription unit for its utilization (Nut site). This pAS1 plasmic closely resembles the earlier constructed pKC30cII, also a regulatory protein which activates promoters for lysogenic development.Type: GrantFiled: January 16, 1986Date of Patent: May 15, 1990Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: Martin Rosenberg
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Patent number: 4923985Abstract: A process for synthesizing a 12 membered ring tetraaza macromolecule comprising. The process involves condensing an amide of ethylene diamine having a general formula A: ##STR1## wherein n is an integer from 1 to 5 and w is a member selected from the group consisting of --NO.sub.2, --NH.sub.2, --NCS, --COOH, --OCH.sub.2 OOCH.sub.3, --NCOCH.sub.2 --Z with Z being a member selected from the group consisting of Br and I with a nitrogen blocked active ester of a general formula B: ##STR2## wherein PG is an amino protecting group and E is a leaving group.Type: GrantFiled: May 25, 1988Date of Patent: May 8, 1990Assignee: The United States of America as represented by the Department of Health & Human ServicesInventors: Otto A. Gansow, Krishan Kumar