Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.

Abstract: Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of an irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering.

Abstract: Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and a bittering agent in an effective amount to impart a bitter taste to an abuser upon administration of the dosage form after tampering.

Abstract: Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of a bittering agent to impart a bitter taste to an abuser upon administration of said dosage form after tampering.

Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.

Abstract: A compound of the having the general formula (I) or general formula (II): wherein Z, A, B, C, R1, R2, Q, W, and n are as described herein.

Abstract: A compound of the formula (I): wherein Z, A, B, C, R1, R2, X1, X2, Q and n are as disclosed herein.

Abstract: When installed in the device, the endoprosthesis is compressed radially and located in a cylindrical chamber (14), one proximal area (A) of this endoprosthesis lies within a first outer catheter (3) and a second distal area (B) is in a second outer catheter (30). In order to release the endoprosthesis (1) in a vessel (11), for example, the second outer catheter (30) is first retracted. The endoprosthesis (1) is then held in the first outer catheter (3) by friction and can be re-folded and thus repositioned by advancing the second outer catheter (30). Finally, the endoprosthesis (1) is released by retracting the first outer catheter (3). Because the friction is distributed over at least two outer catheters (3, 30), even endoprostheses (1) that generate a high level of friction on the outer catheter, for example because of a coating, of greater expansion force, or because of great length, can be released.

Abstract: The pressure measuring guide wire comprises an elongated flexible shaft with a lumen extending therethrough. The lumen is surrounded by a wall forming the shaft and the distal portion of which is provided with slots for pressure medium entry. The distal portion has a thickness, greater than the thickness of the proximal area of the shaft. A coil surrounds the proximal area of the shaft to compensate the difference in kinking resistance between the proximal and distal areas of the shaft.

Abstract: The guide wire of this invention is especially suited for the percutaneous introduction of a balloon dilatation catheter into a blood vessel. It contains a flexible shaft with a proximal portion and a distal portion. A flexible helical coil assembly surrounds the distal portion of the shaft. The helical coil assembly has a radiographically visible distal helical coil and a proximal radiographically invisible helical coil. The proximal helical coil and the distal helical coil are attached to each other by a connecting helical coil that on one end is screwed into the proximal helical coil and on the other end is screwed into the distal helical coil.

Abstract: A catheter is disclosed having a proximal shaft formed from an inner liner formed from a copolymer of polyvinylidene fluoride and hexafluoropropylene, an outer jacket formed from a blend of nylon and polyether block amide or polyether block amide alone, and a soft flexible tip affixed to the distal end of the proximal shaft formed from polyether block amide. A stem may be located between the proximal shaft and the soft flexible tip. The stem has an outer jacket formed from a proximal stem transition sleeve with a tapered distal end and a distal stem sleeve with a complementary tapered proximal end connected to the tapered distal end of the proximal stem transition sleeve. The stem transition sleeve and the stem sleeve are both formed from polyether block amide alone or a blend of polyether block amide and nylon. The outer jacket may be the same hardness as or harder than the stem transition sleeve which in turn is harder than the stem sleeve and the soft flexible tip.

Abstract: A process for rendering the surfaces of polymeric plastic or rubber materials, which are intrinsically non-polar or only slightly polar, and hydrophobic, polar or more polar, and hydrophilic, so that amine-containing functional groups, and ultimately, a durable tenaciously adhering, slippery polyurethane or polyurethane-urea hydrogel coating may subsequently be applied to the polymer surface, is disclosed.

Abstract: An interventional catheter for angioplasty and the like, comprising a catheter tube formed of two superposed layers of materials different from one another. The inner layer is comprised of a low friction nonkinkable material to avoid risk of clogging of a guide wire in the longitudinal lumen. The outer layer is comprised of a material with higher friction coefficient than the material forming the inner layer. The balloon is welded at its distal end to the outer layer of the catheter tube. The proximal end of the balloon is welded to a tube surrounding the catheter tube.

Abstract: The pressure monitoring guidewire comprises an elongated tube made of one piece of elastic Nickel Titanium alloy. The distal end portion of the tube has transverse openings formed through the tube wall for the entry of pressure waves into a lumen. The distal end portion of the tube which encompasses the openings, is malleable. The pressure monitoring guidewire can be formed by thermally treating the distal end portion of a guidewire formed of an elongated tube of one piece of elastic Nickel Titanium alloy having a distal end portion with transverse openings.

Abstract: A body compatible device including an elongate filament substantially uniform in lateral cross-section over its length and having multiple fibers having high tensile strength embedded in a polymeric material. The polymeric material may be melted onto the fibers, and the filament may have an elongate polymeric case surrounding the filament. The body compatible device may be a stent of a tubular latticework.

Abstract: An intravascular catheter having an elongated tubular body with a proximal portion, a distal portion and a lumen extending therebetween. The tubular body is formed with: (a) a first layer of polytetrafluoroethylene; (b) a reinforcing means at least partially surrounding the inner layer; and (c) a second layer comprising a blend of polyetherester elastomer and polybutylene terephthalate at least partially covering the second layer.

Abstract: An improved catheter having at least one lumen with a nonlinear inflation lumen flow portion that may be used with a balloon or in a guide catheter. Additionally disclosed is a catheter assembly having a nonlinear flow portion for contrast media delivery. The nonlinear flow portions facilitate hydraulic and mechanical characteristics relating to deflation of a balloon, the flow rate of fluid, contrast media or the like, and relative performance.

Abstract: A catheter assembly for the treatment of vessels carrying body fluid, comprising an inner catheter provided with a guidewire lumen for receiving a guidewire and an inflation lumen for a balloon provided at its distal end. The catheter assembly further comprises an outer catheter provided with an inflation lumen for a balloon provided at its distal end and a lumen in which the inner catheter is applied shiftable for changing the spacing of the two balloons and which features a larger cross-section than that of the inner catheter so that between the outer wall of the inner catheter and the inner wall of the outer catheter a cross-section employable as an inflation lumen exists and ports into the portion sited between the two balloons.

Abstract: A body compatible stent is formed of multiple filaments arranged in two sets of oppositely directed helical windings interwoven with one another in a braided configuration. Each of the filaments is a composite including a central core and a case surrounding the core. In the more preferred version, the core is formed of a radiopaque and relatively ductile material, e.g. tantalum or platinum. The outer case is formed of a relatively resilient material, e.g. a cobalt/chromium based alloy. Favorable mechanical characteristics of the stent are determined by the case, while the core enables in vivo imaging of the stent. The composite filaments are formed by a drawn filled tubing process in which the core is inserted into a tubular case of a diameter substantially more than the intended final filament diameter. The composite filament is cold-worked in several steps to reduce its diameter, and annealed between successive cold-working steps.

Abstract: A docking assembly for the extension of a guidewire. The docking assembly comprises a plug formed at the proximal end of the guidewire, and a socket formed of a tubing permanently bent so as to have a V shaped portion comprised between two straight portions. The end of straight portion is affixed to the distal end of extension wire. A sleeve is slidably engaged over the tubing to substantially straighten it and facilitate insertion of plug into the tubing. Removal of sleeve allows the tubing to recover its preshaped deformation, thereby assuring locking of plug in tubing. To release the assembly it suffices to pull the guidewire and extension wire oppositely to slip the plug out from the tubing.