Patents Represented by Attorney Richard E. Vila
  • Patent number: 4892941
    Abstract: Disclosed are tetraphenyl porphyrins which are beta-substituted by fluoro or chloro and/or bear electronegative substituents on the phenyl including one or two water solubilizing substituents. The new porphorins are particularly suitable as catalysts in a variety of oxidative reactions and methods.
    Type: Grant
    Filed: April 15, 1988
    Date of Patent: January 9, 1990
    Inventors: David H. Dolphin, Taku Nakano, Thomas K. Kirk, Tilak P. Wijesekera, Roberta L. Farrell, Theodore E. Maione
  • Patent number: 4891396
    Abstract: A compound of formula I ##STR1## in which R.sub.1 is selected from C.sub.9-32 alkyl, C.sub.9-32 alkenyl, C.sub.9-32 alkoxy, --CO--R.sub.4 and --(CH.sub.2).sub.1-6 --COOC.sub.6-18 alkyl, where R.sub.4 is C.sub.8-31 alkyl, C.sub.8-31 alkenyl or C.sub.8-31 alkoxy; the alkyl group of each significance of R.sub.1 being uninterrupted or interrupted by one --O--, --S-- --SO.sub.2 -- group and being unsubstituted or substituted by --N(R.sub.5).sub.2, OH or halogen, where each R.sub.5, independently, is selected from hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl and C.sub.1-6 alkoxy;R.sub.2 has a significance of R.sub.1 independently, of R.sub.1 or is --COOH hydrogen, hydroxyC.sub.1-6 alkyl, hydroxyC.sub.1-6 alkoxy, --COOC.sub.1-6 alkyl, OCOC.sub.1-6 alkoxy; Cl, Br, I, OH, C.sub.1-8 alkyl, C.sub.1-8 alkoxy or C.sub.2-8 alkenyl; andR.sub.3 is C.sub.1-6 alkyl, Cl, Br, I, OH, COOH, hydroxyC.sub.1-6 alkyl, C.sub.2-6 alkenyl, hydroxyC.sub.1-6 alkoxy, COOC.sub.1-6 alkyl, --OCOC.sub.1-6 alkoxy or C.sub.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: January 2, 1990
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Helmut Bohnke
  • Patent number: 4889535
    Abstract: Compounds of the formula ##STR1## and mixtures thereof, wherien p1 R.sub.1 is hydrogen, chloro or bromo, p1 R.sub.2 is hydrogen, chloro, bromo or nitro, p1 R.sub.3 is hydrogen, chloro, bromo, nitro or --SCN, p1 R.sub.4 is hydrogen, chloro or bromo, p1 R.sub.5 is hydrogen or C.sub.1-4 alkyl, and p1 R.sub.5 is C.sub.8-14 alkyl,with the provisos that (i) at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is other than hydrogen, (ii) when R.sub.3 is nitro or --SCN, R.sub.2 is other than nitro, and (iii) when two or more of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are halo, then R.sub.3 is one of those halos, are useful as disperse dyes for dyeing substrates such as synthetic and semi-synthetic, hydrophobic, high molecular weight organic materials.
    Type: Grant
    Filed: March 13, 1987
    Date of Patent: December 26, 1989
    Assignee: Sandoz Ltd.
    Inventor: Beat Henzi
  • Patent number: 4889945
    Abstract: The invention relates to phosphoric acid partial esters derived from a block ethoxylated and propoxylated C.sub.9-16 aliphatic alcohol. These phosphoric acid partial esters are useful as wetting agents, especially in the pre-treatment of cellulosic textile materials.
    Type: Grant
    Filed: April 6, 1989
    Date of Patent: December 26, 1989
    Assignee: Sandoz Ltd.
    Inventor: Achim Wiedemann
  • Patent number: 4885325
    Abstract: A quaternized aminoamide-modified wax obtainable by amidating, with a polyamine containing a single primary amino group, a carboxy group-containing, oxidized hydrocarbon wax which may be partially saponified, and quaternizing at least one amino group of the resulting aminoamide-modified wax, optionally in admixture with a non-oxidized paraffin wax may be applied, preferably in the form of an aqueous dispersion containing a dispersing agent, to a fibrous substrate to improve its workability in mechanical processes.
    Type: Grant
    Filed: April 26, 1988
    Date of Patent: December 5, 1989
    Assignee: Sandoz Ltd.
    Inventors: Bernard Danner, Eckart Schleusener
  • Patent number: 4883615
    Abstract: A process for flameproofing a substrate comprising applying to the substrate a compound of formula I ##STR1## in which R.sub.1.sup..sym. is a N.sup..sym. cation defined in the Specification and R.sub.2 and R.sub.3 are organic radicals.Substrates to which the compound of formula I can be applied include cellulosic substrates.
    Type: Grant
    Filed: July 14, 1986
    Date of Patent: November 28, 1989
    Assignee: Sandoz Ltd.
    Inventors: Tibor Robinson, Rainer Wolf
  • Patent number: 4881941
    Abstract: A textile substrate is dyed by immersing it in a gathered configuration into an oil medium containing a dissolved or dispersed dye for a sufficient time to allow the oil medium to come into contact with part but not all of the surface of the substrate and the thus-treated substrate is then preferably immersed in an aqueous medium having another dye dissolved or dispersed therein.
    Type: Grant
    Filed: July 12, 1988
    Date of Patent: November 21, 1989
    Assignee: Sandoz Ltd.
    Inventor: Michael W. Dixon
  • Patent number: 4880430
    Abstract: Water-dilutable compositions consisting essentially of(a) an acylated polyamine derivative selected from the group consisting of:1. a polyamine acylated by introduction of at least one radical of a C.sub.12-24 -fatty acid and oxyalkylated,2. an alkylated derivative of 1.,3. a quaternated derivative of 1 or 2,4. a protonated derivative of 1., 2. or 3.,or a mixture thereof and(b) an alcohol-ether of the average formulaR--O--CH.sub.2 --CH.sub.2 --O).sub.n H (I),wherein R is C.sub.1-4 -alkyland n is a number from 3 to 12and optionally(c) a hydrophilic surfactantare eminently suitable for finishing, in particular softening, fibrous material.
    Type: Grant
    Filed: March 31, 1988
    Date of Patent: November 14, 1989
    Assignee: Sandoz Ltd.
    Inventor: Eckart Schleusener
  • Patent number: 4879373
    Abstract: each of R.sub.2 and R.sub.3 is independently hydrogen, chloro, bromo, methyl, methoxy or ethoxy,useful as pigments for, for example, the mass pigmenting of viscose and surface coatings such as oil and water base paints, lacquers and inks, pigment printing, textile coating and pigmenting paper in the mass.
    Type: Grant
    Filed: February 19, 1987
    Date of Patent: November 7, 1989
    Assignee: Sandoz Ltd.
    Inventor: Bansi L. Kaul
  • Patent number: 4877412
    Abstract: Compounds of the formula ##STR1## in free acid or salt form and internal, external and acid addition salts thereof, whereinK is ##STR2## wherein R.sub.3 -R.sub.5, R.sub.20, R.sub.21 and X-Z are as defined in the specification,each of Q.sub.1 and Q.sub.2 is independently hydrogen or --SO.sub.3 M.sub.1,each R.sub.1 and R.sub.2 is independently hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or --COOM, andn is 0 or 1,wherein each M and M.sub.1 is independently hydrogen or a nonchromophoric cation, with the provisos that (i) the compound contains at least one --SO.sub.3 M or --SO.sub.3 M.sub.1 group, (ii) when K is a gruop of Formula (a), at least one of R.sub.4 and R.sub.5 is hydrogen, (iii) the total number of anionic groups equals or exceeds the total number of basic and cationic groups, (iv) the positive charge of each cationic group is balanced by the negative charge of an --SO.sub.3.sup..crclbar. or --COO.sup..crclbar.
    Type: Grant
    Filed: March 31, 1988
    Date of Patent: October 31, 1989
    Assignee: Sandoz Ltd.
    Inventor: Reinhard Pedrazzi
  • Patent number: 4876342
    Abstract: Oxazine compounds containing basic groups correspond to the formula ##STR1## wherein the symbols are as defined in the Specification. These compounds are suitable for dyeing or printing organic substrates containing hydroxy groups or nitrogen in accordance with known methods. Preferred substrates are textile materials which consist of or contain natural or regenerated cellulose, e.g. cotton, but also bast fibres or leather. Most preferred substrates are paper or paper products. Furthermore, these compounds can be used to prepare all kinds of inks, such as ball-pen inks or printing inks.Similarly, a mixture of one or more of the above compounds together with one or more copper phthalocyanine dyes containing basic and/or cationic groups can be used as dyeing or printing agent.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: October 24, 1989
    Assignee: Sandoz Ltd.
    Inventor: Reinhard Pedrazzi
  • Patent number: 4876299
    Abstract: A compound of formula I ##STR1## in which R, R.sub.1, R.sub.10 and R.sub.11 are organic radicals. These compounds are suitable as U.V. absorbers.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: October 24, 1989
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4875903
    Abstract: Compounds of the formula ##STR1## wherein each R.sub.1 is independently hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by hydroxy, halo, cyano or C.sub.1-4 alkoxy,each of X.sub.1 and X.sub.3 is independently halo, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenyl, phenoxy, amino or an aliphatic, cycloaliphatic, aromatic or heterocyclic amino group,each of X.sub.2 and X.sub.4 is independently an aliphatic, cycloaliphatic, aromatic or heterocyclic amino group containing at least one protonatable nitrogen atom or quaternary ammonium group,m is 0 or 1, andeach of n.sub.1 and n.sub.2 is independently 0 or 1, with the proviso that n.sub.1 +n.sub.2 is 1 or 2,wherein each halo is independently fluoro, chloro or bromo, with the provisos that (1) the total number of basic and cationic groups present as X.sub.1 -X.sub.
    Type: Grant
    Filed: June 5, 1987
    Date of Patent: October 24, 1989
    Assignee: Sandoz Ltd.
    Inventor: Reinhard Pedrazzi
  • Patent number: 4876280
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, C.sub.1-3 alkyl, n-butyl, i-butyl or t-butyl, R.sub.2 is hydrogen or C.sub.1-3 alkyl,R.sub.3 is hydrogen or C.sub.1-3 alkyl,R.sub.4 is hydrogen, C.sub.1-3 alkyl, n-butyl, i-butyl or t-butyl,R.sub.5 is hydrogen, C.sub.1-3 alkyl, n-butyl, i-butyl, t-butyl, C.sub.1-3 alkoxy, n-butoxy, i-butoxy, fluoro, chloro, trifluoromethyl, phenoxy or benzyloxy,R.sub.6 is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, fluoro, chloro, trifluoromethyl, phenoxy or benzyloxy, with the provisos that not more than one of R.sub.5 and R.sub.6 is trifluoromethyl, not more than one of R.sub.5 and R.sub.6 is phenoxy, and not more than one of R.sub.5 and R.sub.6 is benzyloxy, orR.sub.5 and R.sub.6 are attached to adjacent carbon atoms and taken together form a radical of the formula --CH.dbd.CH--CH.dbd.CH--,R.sub.6a is hydrogen, C.sub.1-2 alkyl, fluoro or chloro,X is --CH.sub.2 CH.sub.2 -- or ##STR2## wherein R.sub.7 is hydrogen or C.sub.1-3 alkyl, andR.sub.8 is hydrogen, R.
    Type: Grant
    Filed: March 10, 1988
    Date of Patent: October 24, 1989
    Assignee: Sandoz Pharm. Corp.
    Inventor: Robert E. Damon, II
  • Patent number: 4874392
    Abstract: A Monoazo compounds of the formula ##STR1## wherein D is a diazo component radical of the 4-nitrophenyl series, thienyl-2 series, thiazolyl-2 series or 5-nitrobenzoisothiazolyl-3 series,R.sub.1 is hydrogen; C.sub.1-2 alkyl; C.sub.1-2 alkoxy; formylamino; (C.sub.1-4 alkyl)carbonylamino; (C.sub.1-4 alkyl)carbonylamino the alkyl group of which is substituted by 1 to 3 substituents independently selected from halo, C.sub.1-3 alkoxy, cyano, phenyl, phenoxy and benzyloxy; (C.sub.2-4 alkenyl)carbonylamino; halo(C.sub.2-4 alkenyl)carbonylamino; benzoylamino; benzoylamino the phenyl group of which is substituted by 1 to 3 substituents independently selected from halo, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; (C.sub.1-4 alkoxy)carbonylamino; (C.sub.1-4 alkoxy)carbonylamino the alkyl moiety of which is substituted by 1 to 3 substituents independently selected from halo, C.sub.1-3 alkoxy, cyano, phenyl, phenoxy and benzyloxy; (C.sub.8-14 alkyl)carbonylamino or (C.sub.8-14 alkoxy)carbonylamino,R.sub.2 is C.sub.
    Type: Grant
    Filed: July 29, 1987
    Date of Patent: October 17, 1989
    Assignee: Sandoz Ltd.
    Inventor: Beat Henzi
  • Patent number: 4870199
    Abstract: Process for the synthesis of compounds of the formula ##STR1## in R[R*,S*] enantiomeric form, wherein each P.sub.1 is independently an hydroxy group-protecting group, andR.sub.2z is C.sub.1-4 alkyl, benzyl or allyl,comprising, as a key step when R.sub.2z is R.sub.2x, the reaction of the compound of the formula ##STR2## in (S) enantiomeric form with a compound of the formulaMg.sup. .circle.+2 (.sup..crclbar. OOC--CH.sub.2 --COOR.sub.2x).sub.2to obtain a compound of the formula ##STR3## in (S) enantiomeric form, and, as a key step when R.sub.2z is R.sub.2y, the reaction of a compound of the formula ##STR4## in (S) enantioimeric form with a compound of the formulaLi.sup..sym..crclbar. CH.sub.2 --COOR.sub.2yto obtain a compound of the formula ##STR5## in (S) enantiomeric form, wherein R.sub.2x is primary or secondary C.sub.1-4 alkyl, benzyl or allyl,R.sub.2y is C.sub.1-4 alkyl not containing an asymmetric carbon atom, andR.sub.
    Type: Grant
    Filed: March 10, 1988
    Date of Patent: September 26, 1989
    Assignee: Sandoz Pharm. Corp.
    Inventors: Kau-Ming Chen, Goetz E. Hardtmann, Prasad K. Kapa, George T. Lee, Jerome Linder, Sompong Wattanasin
  • Patent number: 4870119
    Abstract: Water-soluble cross-linked polyamides are produced by reacting (B) a cross-linking agent with (A) the product of reacting (A.sub.1) a dicarboxylic acid and (A.sub.2) a polyamine, provided that at least one of (A.sub.1) (A.sub.2) and (B) contains an aromatic moiety or that the product of reacting (B) with (A) is further reacted with a compound containing an aromatic moiety. The products are useful as binders for aqueous printing inks.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: September 26, 1989
    Assignee: Sandoz Ltd.
    Inventors: Benjamin K. C. Yee, William L. Younan
  • Patent number: 4866163
    Abstract: Compounds of the formula ##STR1## wherein each R.sub.1 is independently hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or --NHCOC.sub.1-4 alkyl, each R.sub.2 is H, halo, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, each R.sub.3 is independently halo, hydroxy, C.sub.1-4 alkoxy, --NHOH, amino or an aliphatic, aromatic cycloaliphatic or saturated heterocyclic amino radical, and is divalent aliphatic or aromatic group or, together with the NH radicals to which it is attached, forms a piperazine ring, and the use thereof for dyeing or printing hydroxy group- or nitrogen-containing organic substrates after which the dyed or printed substrate is optionally treated with a cationic fixing agent.
    Type: Grant
    Filed: May 2, 1984
    Date of Patent: September 12, 1989
    Assignee: Sandoz, Ltd.
    Inventor: Werner Koch
  • Patent number: 4866113
    Abstract: A pigment, which retains a crystal or particulate structure throughout a process of coloration of a substrate, containing one or more 2,2,6,6-tetraalkylpiperidine groups.
    Type: Grant
    Filed: April 19, 1988
    Date of Patent: September 12, 1989
    Assignee: Sandoz Ltd.
    Inventors: Peter Bitterli, Manfred Geisel, Jurgen Goldmann, Bansi L. Kaul
  • Patent number: 4863740
    Abstract: Interleukin-2 liposomes are advantageous sustained release formulations.
    Type: Grant
    Filed: May 12, 1988
    Date of Patent: September 5, 1989
    Assignee: Sandoz Ltd.
    Inventors: Thomas Kissel, Jurg Reinhardt, Henriette Schrank