Patents Represented by Attorney Richard E. Vila
  • Patent number: 4822799
    Abstract: Compounds of the formula ##STR1## and processes for and intermediates in the synthesis thereof, pharmaceutical compositions comprising such a compound and the use of such compounds for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: April 18, 1989
    Assignee: Sandoz Pharm. Corp.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4820309
    Abstract: Complexes of the formula ##STR1## wherein each R.sub.1 is independently (a) the radical of a coupling component of the active methylene non-cyclic or homocyclic series, (b) the radical of a coupling component of the heterocyclic series or (c) the radical of a coupling component of the monocyclic benzene series,with the proviso that at least one R.sub.1 is the radical of a coupling component of the active methylene non-cyclic or homocyclic series,each R.sub.2 is independently hydrogen, C.sub.1-4 alkyl or --SO.sub.2 NR.sub.4 R.sub.5,each R.sub.3 is independently hydrogen, halo, C.sub.1-4 alkyl or --SO.sub.2 NR.sub.4 R.sub.5, andeach M and M.sub.1 is independently hydrogen or a cation,wherein each R.sub.4 is independently hydrogen, C.sub.1-4 alkyl or C.sub.2-3 hydroxyalkyl, andeach R.sub.5 is independently hydrogen, C.sub.1-4 alkyl, C.sub.2-3 hydroxyalkyl, cyclohexyl, cyclohexyl substituted by methyl, phenyl or phenyl substituted by methyl, with the proviso that at least one of Ring A and R.sub.
    Type: Grant
    Filed: March 3, 1988
    Date of Patent: April 11, 1989
    Assignee: Sandoz Ltd.
    Inventor: Herbert Holliger
  • Patent number: 4820808
    Abstract: Complexes of the formula ##STR1## and salts thereof each cation of which is independently a non-chromophoric cation,wherein B is --CO--CH.dbd.CH--CO--, --CO--(CH.sub.2).sub.a --CO--, ##STR2## and each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is independently hydrogen, halo, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkyoxy, --NHCO--R.sub.6, --CO--R.sub.7 or --SO.sub.2 --R.sub.8,wherein R.sub.6 is C.sub.1-4 alkyl or phenyl,R.sub.7 is hydroxy; --OR.sub.9 ; C.sub.1-4 alkyl; phenyl; phenyl substituted by 1 or 2 substituents selected from halo, nitro, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; cyclohexyl; cyclohexyl substituted by 1 to 3 C.sub.1-4 alkyl groups; or --NR.sub.10 R.sub.11, and,R.sub.8 is hydroxy; C.sub.1-4 alkyl; C.sub.1-4 alkyl monosubstituted by halo or sulfato; C.sub.2-4 alkenyl; phenyl; phenyl substituted by 1 or 2 substituents selected from halo, nitro, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; cyclohexyl; cyclohexyl substituted by 1 to 3 C.sub.1-4 alkyl groups; or --NR.sub.10 R.sub.
    Type: Grant
    Filed: November 5, 1986
    Date of Patent: April 11, 1989
    Assignee: Sandoz Ltd.
    Inventors: Kurt Brenneisen, Friedrich Lehr
  • Patent number: 4820806
    Abstract: Metal-free monoazo and disazo compounds of the formulaCH.sub.2 .dbd.CH--SO.sub.2 --W.sub.1 --D--N.dbd.N--K--(W.sub.2 --Z).sub.n,1:1 and 1:2 metal complexes of such metallizable metal-free compounds and acid addition salts of such metal-free compounds and 1:1 and 1:2 metal complexes, whereinD is the radical of a diazo component of the benzene, naphthalene or tetrahydronaphthalene series,K is the radical of a coupling component of the benzene, naphthalene, pyrazol-5-one, pyridine, pyridone, barbituric acid, quinoline, isoquinoline, benzeneazobenzene, benzeneazonaphthalene, naphthaleneazobenzene, naphthaleneazonaphthalene, tetrahydronaphthaleneazobenzene, tetrahydronaphthaleneazonaphthalene or acetoacetamide series,W.sub.1 is a direct bond or a divalent bridging radical,each W.sub.
    Type: Grant
    Filed: February 28, 1986
    Date of Patent: April 11, 1989
    Assignee: Sandoz, Ltd.
    Inventors: Werner Baumann, Joseph V. Diest, Herbert Eichenberger, Max Oppliger
  • Patent number: 4808607
    Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
    Type: Grant
    Filed: November 20, 1987
    Date of Patent: February 28, 1989
    Assignee: Sandoz Pharm. Corp.
    Inventor: James R. Wareing
  • Patent number: 4806656
    Abstract: The invention provides compounds of formula I ##STR1## wherein R is C.sub.1-4 alkoxy-C.sub.2-4 alkyl of which the C.sub.1-4 alkoxy group is separated by at least 2 C-atoms from the N-atom to which R is bound,each of R.sub.2 and R.sub.4 independently is CH.sub.3 or C.sub.2 H.sub.5 andR.sub.5 is H or CH.sub.3,the preparation of such compounds and the use of such compounds for the preparation of N-(thien-3-yl)-chloroacetamides.
    Type: Grant
    Filed: August 5, 1985
    Date of Patent: February 21, 1989
    Assignee: Sandoz Ltd.
    Inventor: Hermann Schneider
  • Patent number: 4804679
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-3 alkyl, andZ is ##STR2## wherein R.sub.7 is hydrogen, R.sub.8 or M,whereinR.sub.8 is a physiologically acceptable and hydrolyzable ester group, andM is a pharmaceutically acceptable cation,the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
    Type: Grant
    Filed: August 6, 1987
    Date of Patent: February 14, 1989
    Assignee: Sandoz Pharm. Corp.
    Inventor: Paul L. Anderson
  • Patent number: 4802887
    Abstract: A composition comprising:(a) 30 to 90% by weight of one or more water soluble anionic dyestuffs in metal complex form,(b) 0.5 to 20% by weight of one or more compounds of formula I ##STR1## in which R.sub.1 is C.sub.12-22 alkyl or C.sub.12-22 alkenyl; R.sub.2 is hydrogen or --SO.sub.3 M;m is 2, 3 or 4;n is 2, 3 or 4;p+p' is 10 to 30 inclusive, each of p and p' being at least 1; and M is a cation; and(c) 5 to 40% by weight of a dispersing agent.These compositions are suitable for dyeing of textile and leather substrates.
    Type: Grant
    Filed: March 10, 1987
    Date of Patent: February 7, 1989
    Assignee: Sandoz Ltd.
    Inventor: Kamal Ateya
  • Patent number: 4801303
    Abstract: Polyester-cotton blend textile substrates are dyed with a disperse dye and then with a sulfur dye from the same dyebath which is maintained at a temperature no higher than 105.degree. C. when the sulfur dye is present therein and which preferably contains glucose as the reducing agent for the sulfur dye.
    Type: Grant
    Filed: June 1, 1987
    Date of Patent: January 31, 1989
    Assignee: Sandoz Ltd.
    Inventors: Mark S. Carlough, Laszlo A. Meszaros
  • Patent number: 4797131
    Abstract: Leather, hides, skins or fur-skins are treated before and/or during dyeing with basic dyes, with a compound of formula I ##STR1## in which R.sub.1 is a C.sub.8-18 aliphatic residue;each R.sub.2, independently, is C.sub.1-4 alkyl;R.sub.3 is a C.sub.1-18 aliphatic residue or --CH.sub.2 -R.sub.4 where R.sub.4 is phenyl; phenyl substituted by up to two substituents selected from the group consisting of chlorine, bromine, methyl, methoxy and ethoxy; or naphthyl; andX is an anion,or a mixture thereof. Dyeings with improved levelness and reproducibility are thus obtained.
    Type: Grant
    Filed: February 19, 1987
    Date of Patent: January 10, 1989
    Assignee: Sandoz Ltd.
    Inventor: Hans-Peter Baumann
  • Patent number: 4797279
    Abstract: The invention provides hybrid microorganisms comprising the gene coding for b.t. kurstaki delta-endotoxin and the gene coding for b.t. tenebrionis delta-endotoxin, their preparation, insecticidal compositions comprising such microorganisms and their use.
    Type: Grant
    Filed: October 28, 1986
    Date of Patent: January 10, 1989
    Assignee: Sandoz Ltd.
    Inventors: Dimitri Karamata, Jean-Christophe Piot
  • Patent number: 4795640
    Abstract: A solvent-free oil-in-water emulsion of propetamphos comprising(a) 5 to 50% by weight of technical propetamphos in the form of droplets having a particle size of below 5 micron,(b) 1 to 8% by weight of a polyvinyl alcohol,(c) 1 to 3% by weight of a buffer, buffering the pH of the formulation to pH 6 to 7,(d) 1 to 2% by weight of a vegetable oil,(e) 0.5 to 2% by weight of an emulsifier(f) 0 to 8% by weight of an antifreezing agent(g) 0 to 0.1% by weight of an antifoaming agent (h) 0 to 0.1% by weight of a perfume,the balance being water, and a process of preparing such emulsion.
    Type: Grant
    Filed: June 8, 1987
    Date of Patent: January 3, 1989
    Assignee: Sandoz Ltd.
    Inventor: Hans Helfenberger
  • Patent number: 4785083
    Abstract: Mixtures comprising at least two dyes of formula I ##STR1## where R is unsubstituted linear C.sub.3-7 alkyl, with the proviso that at least two different dyes of formula I are each present to the extent of at least 10 mole %, based on the total molar quantity of dyes present, which are useful for dyeing and printing synthetic and semi-synthetic high molecular weight, hydrophobic organic substrates, particularly for rapid dyeing.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: November 15, 1988
    Assignee: Sandoz Ltd.
    Inventor: Ulrich Zirngibl
  • Patent number: 4783475
    Abstract: The invention provides a method of combatting fungal diseases with the aid of(a) the compound of formula I ##STR1## and (b) the compound of formula II ##STR2## and fungicidal compositions comprising said compounds.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: November 8, 1988
    Assignee: Sandoz Ltd.
    Inventor: Hans Wiedmer
  • Patent number: 4780106
    Abstract: Metal-free compounds of the formula ##STR1## 1:1 and 1:2 metal complexes thereof, and acid addition salts of metal-free compounds of said formula and 1:1 and 1:2 metal complexes thereof, whereinB is hydrogen; C.sub.1-4 alkyl; C.sub.1-4 alkyl monosubstituted by C.sub.1-4 alkoxy; C.sub.2-4 alkyl substituted by hydroxy; C.sub.5-6 cycloalkyl; C.sub.5-6 cycloalkyl substituted by 1 to 3 C.sub.1-4 alkyl groups; phenyl(C.sub.1-3 alkyl); phenyl(C.sub.1-3 alkyl) the phenyl group of which is substituted by 1 to 3 substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halo; --A--NH--R.sub.2 ; --A'.sub.4 --N(R.sub.7).sub.2 ; --A.sub.4 --N.sup..sym. (R.sub.8).sub.2 R.sub.9 A.sup..crclbar. or --N(R.sub.7).sub.2,R is hydrogen; C.sub.1-4 alkyl; C.sub.5-6 cycloalkyl; C.sub.5-6 cycloalkyl substituted by 1 or 2 C.sub.
    Type: Grant
    Filed: June 10, 1987
    Date of Patent: October 25, 1988
    Assignee: Sandoz Ltd.
    Inventors: Helmut Moser, Manfred Greve, Reinhard Pedrazzi, Roland Wald
  • Patent number: 4780494
    Abstract: An aqueous dispersion comprising one or more 2,2,6,6-tetraalkylpiperidine compounds having a molecular weight 2000 or less than 2000 and a melting point of 100.degree. C. or more, one or more cationic, non-ionic and/or anionic dispersing agents and an aqueous medium. These dispersions are suitable for use as light stabilizers in aqueous systems.
    Type: Grant
    Filed: April 11, 1985
    Date of Patent: October 25, 1988
    Assignee: Sandoz Ltd.
    Inventors: Erwin Hess, Rainer Wolf
  • Patent number: 4780222
    Abstract: A water soluble or water dispersible composition containing(a) at least one phosphoric acid partial ester(b.sub.1) at least one mono- or di-(C.sub.2-3 alkylene) glycol mono-(C.sub.1-4 -alkyl) ether or at least one aliphatic C.sub.4-6 alcohol or a mixture thereof(b.sub.2) mono- or diethylene glycol or a mixture thereof(c) at least one aromatic-free or aromatic-poor hydrocarbon oil, and(d) a water miscible alkanolamine,the phosphoric acid partial ester (a) being dispersed or dissolved in the mixture (b.sub.1)+(b.sub.2)+(c), and component (a) being at least partially neutralized in salt form, with the proviso that the composition has a water content .ltoreq.5% by weight.It is useful as fatting agent for fatting leather.
    Type: Grant
    Filed: February 12, 1987
    Date of Patent: October 25, 1988
    Assignee: Sandoz Ltd.
    Inventor: Werner Amati
  • Patent number: 4780492
    Abstract: A liquid concentrate comprising an oxamide and a 2,2,6,6-tetraalkylpiperidine compound dissolved in an organic solvent is useful for the UV-stabilization of hardenable liquid finishes, particularly automotive finishes.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: October 25, 1988
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4778476
    Abstract: A method of fatting tanned leather substrates comprising(a) applying to the substrate as the fatting agent an aqueous solution or dispersion of an ortho-phosphoric acid partial ester having attached to the phosphorus atom an average 1 to 2 (which may be a non-integral number) groups of the formula I ##STR1## where each A independently is ##STR2## and n is a number from 2 to 10 with the proviso that 2 to 6 groups A are --(CH.sub.2).sub.2,R is an unsubstituted linear or branched (preferably linear) C.sub.14-20 alkyl group or an unsubstituted linear or branched (preferably linear) C.sub.14-20 alkenyl group,the phosphoric acid partial ester being in free acid or salt form;(b) treating with an agent selected from polyvalent metal oxide, hydroxide and salt, at the same time as fatting or after fatting.
    Type: Grant
    Filed: July 10, 1986
    Date of Patent: October 18, 1988
    Assignee: Sandoz Ltd.
    Inventor: Werner Amati
  • Patent number: 4775410
    Abstract: The subject matter of this invention involves 2-[4-(2-pyridinyloxy)phenoxy]propionyl-2-oxazolidinones which are substituted in the pyridinyl ring by trifluoromethyl and/or chloro. The compounds are useful for increasing the recoverable sugar in sugarcane.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: October 4, 1988
    Assignee: Sandoz Ltd.
    Inventors: Louis G. Nickell, Leonard Stach, Takeo Hokama