Abstract: Relatively high refractive index polymeric compositions and ophthalmic devices such as for example intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the copolymerization of one or more aromatic-substituted polysiloxane prepolymers with one or more aromatic monomers, alkylated monomers or hydrophilic monomers.
Abstract: A process for producing polysiloxane prepolymers of improved homogeneity for use in the production of relatively high refractive index polymeric compositions is described herein. Polymeric compositions so produced are useful in the production of ophthalmic devices such as for example intraocular lenses and corneal inlays. The preferred polymeric compositions are produced through the copolymerization of one or more polysiloxane prepolymers with hydrosilane-containing polysiloxanes.
Abstract: A method for inhibiting the ability of a biomaterial to sorb cationic antimicrobials comprising treating the surface of said biomaterial with a cationic polysaccharide.
Type:
Grant
Filed:
December 15, 2000
Date of Patent:
October 19, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Joseph C. Salamone, Daniel M. Ammon, Jr., Zhenze Hu
Abstract: Contact lens cleaning compositions comprising preserved surfactant-containing solutions of a poly(oxypropylene)-poly(oxyethylene) adduct of ethylene diamine having a molecular weight from about 7500 to as high as 27,000 wherein at least 40 weight percent of the adduct is poly(oxyethylene) hydrophilic units. The solutions are effective in removing protein/lipid tear film deposits on both hard and soft contact lenses while providing a prophylactic-like action in retarding the formation of subsequent tear film deposits. The compositions provide effective cleaning and conditioning action using both ambient and high temperature disinfection methods.
Type:
Grant
Filed:
February 13, 2001
Date of Patent:
September 14, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Erning Xia, Christine E. Soltys-Robitaille, Lisa C. Simpson
Abstract: A process for removing contaminants and/or leachables from polymeric materials useful in the manufacture of biocompatible medical devices such as intraocular lenses, corneal inlays and contact lenses using continuous soxhlet extraction.
Type:
Grant
Filed:
September 27, 2002
Date of Patent:
September 14, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Yu-Chin Lai, Dominic V. Ruscio, David P. Vanderbilt
Abstract: A method for improving the integrity of the corneal epithelium by introducing into the eye an effective amount of a ophthalmically compatible retinoid sufficient to enhance the integrity of the corneal epithelium.
Type:
Grant
Filed:
December 17, 2001
Date of Patent:
September 7, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Andrea M. Lever, Richard V. Smerbeck, O. William Lever, Jr., Joseph C. Salamone
Abstract: Relatively high refractive index polymeric compositions and ophthalmic devices such as for example intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the copolymerization of one or more aromatic-substituted polysiloxane prepolymers with one or more aromatic monomers, alkylated monomers or hydrophilic monomers.
Abstract: An accommodating intraocular lens system including a higher diopter positive intraocular lens and a lower diopter negative intraocular lens. The positive intraocular lens includes a positive optic portion having an outer peripheral edge and two or more haptic elements. The negative intraocular lens includes a negative optic portion having an outer peripheral edge and two or more haptic elements. Each haptic element is formed to have specific flexibility characteristics so as to be less resistant to bending in a plane generally parallel to an eye's optical axis than in a plane generally perpendicular to the eye's optical axis. The accommodating intraocular lens system is so designed with specific flexibility characteristics to facilitate axial displacement of the positive optic portion with respect to the negative optic portion along the eye's optical axis under a compression force.
Type:
Grant
Filed:
November 5, 1999
Date of Patent:
July 27, 2004
Assignee:
Bausch & Lomb Surgical, Inc.
Inventors:
Mark H. Bandhauer, George F. Green, Donald Carrol Stenger, Michael T. Landreville
Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based silyl monomers or the copolymerization of one or more aromatic-based silyl monomers with one or more aromatic or non-aromatic non-siloxy-based monomers, hydrophobic monomers or hydrophilic monomers.
Type:
Grant
Filed:
November 2, 2001
Date of Patent:
July 13, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Joseph C. Salamone, Jay F. Kunzler, Richard M. Ozark, David E. Seelye, David P. Vanderbilt
Abstract: A method of cast molding an intraocular implant from two or more dissimilar materials using disposable molds. The subject cast molding method is particularly useful in the production of intraocular lenses manufactured from dissimilar materials. It is desirable to produce intraocular lenses from dissimilar materials in order to optimize the optical characteristics of the intraocular lens optic portion and to optimize stability and flexibility characteristics of the intraocular lens haptic elements.
Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, corneal inlays and contact lenses made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based siloxane macromonomers or the copolymerization of one or more aromatic-based siloxane macromonomers with one or more non-siloxy aromatic-based monomers, non-aromatic-based hydrophobic monomers or non-aromatic-based hydrophilic monomers.
Type:
Grant
Filed:
November 2, 2001
Date of Patent:
May 4, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Joseph C. Salamone, Jay F. Kunzler, Richard M. Ozark, David E. Seelye
Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, corneal inlays and contact lenses made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based siloxane macromonomers or the copolymerization of one or more aromatic-based siloxane macromonomers with one or more non-siloxy aromatic-based monomers, non-aromatic-based hydrophobic monomers or non-aromatic-based hydrophilic monomers.
Type:
Grant
Filed:
November 2, 2001
Date of Patent:
April 20, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Joseph C. Salamone, Jay F. Kunzler, Richard M. Ozark, David E. Seelye
Abstract: The invention provides an ophthalmic aqueous composition for topical administration, comprising:
(a) a block copolymer of propylene oxide and ethylene oxide in concentration sufficient to provide viscosity of less than about 25 centipoise at ambient temperature and viscosity of from about 25 to about 55 centipoise when applied topically to a patient;
(b) hydroxypropyl methylcellulose in concentration sufficient to improve the durability of the gel formed by the block copolymer.
The invention further provides a method for administering ophthalmic pharmaceuticals.
Abstract: A method is disclosed for inhibiting adhesion of bacteria to the surface of a biomedical device comprising contacting the surface of said biomedical device with a cationic polysaccharide in aqueous solution having an ionic strength of from about 0.01 to about 0.13.
Type:
Grant
Filed:
May 15, 2001
Date of Patent:
March 9, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Zhenze Hu, Joseph C. Salamone, Roya Borazjani
Abstract: Fluorosilicone fluids useful as high-density fluid ocular tamponades and methods of producing, purifying and using the fluorosilicone fluids in an ocular surgical procedure for retinal treatment.
Type:
Grant
Filed:
September 19, 2002
Date of Patent:
March 9, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Jay F. Kunzler, Richard M. Ozark, Joseph C. Salamone
Abstract: An accommodating intraocular lens including an optic portion having an outer peripheral edge and two, three or four balanced haptic elements for use to achieve multifocal refractive correction. Each haptic element is formed to have less resistance to bending in a plane generally parallel to an eye's optical axis than in a plane generally perpendicular to the eye's optical axis. The intraocular lens is designed with specific flexibility characteristics so as to exhibit greater than approximately 1.0 mm axial displacement of the optic portion along the eye's optical axis under a compression force suitable to effect a 1.0 mm in diameter compression of the intraocular lens.
Type:
Grant
Filed:
July 29, 1999
Date of Patent:
February 3, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Michael T. Landreville, Donald Carrol Stenger
Abstract: Optically transparent, high refractive index hydrogels and intraocular lenses fabricated therefrom. The preferred hydrogels have a refractive index of 1.45 or above and a water content of approximately 5 to 30 percent by weight.
Abstract: A nutritional or dietary supplement composition that strengthens and promotes retinal health through the prevention, stabilization, reversal and/or treatment of visual acuity loss by reducing the risk of developing late stage or advanced age-related macular degeneration in persons with early age-related macular degeneration. The nutritional or dietary supplement composition may likewise reduce the risk of vision loss associated with the development of cataracts. The essential ingredients of the nutritional or dietary supplement composition are vitamin C, vitamin E, beta-carotene, zinc and copper. The essential ingredients are preferably provided in a tablet form suitable for oral ingestion. Preferably the composition is taken in the form of one or two tablets taken twice daily.
Type:
Grant
Filed:
March 23, 2001
Date of Patent:
December 9, 2003
Assignee:
Bausch & Lomb Incorporated
Inventors:
Stephen Paul Bartels, Cara Larraine Baustian, George Edwin Bunce, Leon Ellenbogen, Frederick L. Ferris, III, Jin Kinoshita, James Cecil Smith, Jr., David A. Souerwine
Abstract: Optically transparent, high refractive index hydrogels and intraocular lenses fabricated therefrom. The preferred hydrogels have a refractive index of 1.45 or above and a water content of approximately 5 to 30 percent by weight.
Abstract: Optically transparent, high refractive index hydrogels and intraocular lenses fabricated therefrom. The preferred hydrogels have a refractive index of 1.45 or above and a water content of approximately 5 to 30 percent by weight.