Patents Represented by Attorney, Agent or Law Firm Robin M. Silva, Esq.
  • Optimized Fc variants and methods for their generation
    Patent number: 8093357
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: January 10, 2012
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Protein and peptide sensors using electrical detection methods
    Patent number: 6824669
    Abstract: The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: November 30, 2004
    Assignee: Motorola, Inc.
    Inventors: Changming Li, Jaymie Robin Sawyer, Vi-En Choong, George Maracas, Peiming Zhang
  • Apparatus and method for automated protein design
    Patent number: 6804611
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: October 12, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Apparatus and method for automated protein design
    Patent number: 6801861
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: October 5, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street, Yaoying Su
  • Apparatus and method for automated protein design
    Patent number: 6792356
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: September 14, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Magnetic resonance imaging agents for the detection of physiological agents
    Patent number: 6770261
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: August 3, 2004
    Assignee: Research Corporation Technologies
    Inventors: Thomas J. Meade, Scott Fraser
  • Printed circuit boards with monolayers and capture ligands
    Patent number: 6761816
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: July 13, 2004
    Assignee: Clinical Micro Systems, Inc.
    Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen D. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch
  • Target analyte detection using asymmetrical self-assembled monolayers
    Patent number: 6753143
    Abstract: The present invention relates to the use asymmetric monolayer forming species and electroconduit forming species to detect target analytes.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: June 22, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Chunlin Tao, Changjun Yu
  • Combinatorial decoding of random nucleic acid arrays
    Patent number: 6620584
    Abstract: The invention provides methods and compositions for combinatorially decoding arrays.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: September 16, 2003
    Assignee: Illumina
    Inventors: Mark Chee, David R. Walt
  • Multiparameter FACS assays to detect alterations in cell cycle regulation
    Patent number: 6461813
    Abstract: The invention related to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: October 8, 2002
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventor: James Lorens
  • Small molecule library screening using FACS
    Patent number: 6455263
    Abstract: The present invention relates to methods of screening libraries of small molecules such as combinatorial chemical libraries of organic molecules, including peptides and other chemical libraries, for binding to target molecules, using fluoroscence-activated cell sorting (FACS) machines.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: September 24, 2002
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventor: Donald Payan
  • Methods for screening for transdominant effector peptides and RNA molecules
    Patent number: 6455247
    Abstract: Methods and compositons for screening for transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: September 24, 2002
    Assignees: Board of Trustees of the Leland Stanford Junior University, Rigel Pharmaceuticals, Inc.
    Inventors: Garry P. Nolan, S. Michael Rothenberg
  • Nucleic acids encoding RIP3 associated cell cycle proteins
    Patent number: 6428980
    Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
    Type: Grant
    Filed: November 16, 1999
    Date of Patent: August 6, 2002
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ying Luo, PeiWen Yu, Mary Shen, Betty Huang
  • Shuttle vectors
    Patent number: 6391582
    Abstract: The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provided is a method wherein yeast are transformed with a shuttle vector as provided herein. Heterologous nucleic acids flanked by 5′ and 3′ ends identical to a homologous recombination site within the shuttle vector are introduced to the transformed yeast and allowed to homologously recombine with the shuttle vector such that they are inserted into the vector by the yeast organism. The shuttle vector is then recovered and transferred to a mammalian cell for expression.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: May 21, 2002
    Assignee: Rigel Pharmaceuticlas, Inc.
    Inventors: Ying Luo, Pei Wen Yu, James Lorens
  • PCNA-associated cell cycle proteins, compositions and methods of use
    Patent number: 6387658
    Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: May 14, 2002
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ying Luo, Betty Huang
  • Screening methods to identify agents that selectively inhibit hepatitis C virus replication
    Patent number: 6326151
    Abstract: The present invention relates to novel methods for identifying antiviral agents which selectively interfere with viral proteins that override the interferon(IFN)-induced cellular defense mechanisms against viral infection. In particular, the present invention relates to screening assays that identify agents which selectively inhibit the interaction between viral proteins containing an interferon sensitivity determining region (ISDR) and IFN-induced PKR protein kinase. The present invention more particularly relates to screening assays that identify agents which selectively inhibit the interaction between hepatitis C virus (HCV) nonstructural 5A protein (NS5A), which contains an ISDR, and IFN-induced PKR protein kinase. The interaction between the viral ISDR and IFN-induced PKR protein kinase results in the override of IFN-induced cellular defense mechanisms to combat viral infection. Therefore the agents identified using the assays of the invention may have utility as antiviral agents.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: December 4, 2001
    Assignee: University of Washington
    Inventors: Michael G. Katze, Michael J. Gale
  • Systems for electrophoretic transport and detection of analytes
    Patent number: 6290839
    Abstract: The invention relates to compositions and methods useful in the electrophoretic transport of target analytes to a detection electrode comprising a self-assembled monolayer (SAM). Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: September 18, 2001
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Gary Blackburn, Stephen D. O'Connor
  • Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
    Patent number: 6287840
    Abstract: Irreversible cysteine protease inhibitors based upon an alkene bond being conjugated to an electron withdrawing group are disclosed. The inhibitor structure also provides a targeting peptide which is specific for different cysteine proteases. The method of making the inhibitors, and methods of using the inhibitors to inhibit cysteine proteases and for therapy are disclosed.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: September 11, 2001
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: James T. Palmer, David Rasnick, Jeffrey Lee Klaus
  • Nucleic acid mediated electron transfer
    Patent number: 6268150
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: July 31, 2001
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Apparatus and method for automated protein design
    Patent number: 6269312
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: July 31, 2001
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street, Yaoying Su