Abstract: A knife holder having two cylinders journaled for axial and rotatable movement are supported by two spaced-apart clamp blocks. The cylinders are axially and rotatably movable in the clamp blocks. Each cylinder has a continuous longitudinal slot of a cross-sectional shape generally complementary to the cross-sectional shape of the knife clamped therein. The axial movement of one cylinder relative to the other cylinder enables the length of knife edge that is exposed to be varied.

Abstract: A handling device for thin sections, in particular cryosections, which serves as a multifunctional device for transferring, pressing, and holding the thin sections. The device possesses a holder for at least one carrier grid, this holder comprising a base plate and a positively-guided cover plate which can be moved onto the base plate. In addition, means are provided for the purpose of clamping the cover plate against the base plate and hence against a thin section which is present on the carrier grid. A separate holder plate is preferably detachably located in the base plate, the carrier grid being permanently attached to this holder plate, which is matched, in shape and dimensions, to the specimen holder of an electron microscope.

Abstract: Foam capsules with telescopically engaged body and cap portions, also known as hard shell capsules, having a special wall structure, obtained by a microdispersion of a gas in a gelatin solution.The capsule body and cap portions are formed by dipmolding the film-forming mixture obtained by a microdispersion of the gas in a gelatin solution; optionally with the inclusion of a plasticizer and/or coloring agent, and/or flavoring agent, and/or foam stabilizer, and/or gelatin extender.By a suitable choice of the gas proportion in the capsule wall and its micronization level, it is possible, within certain limits, to control the capsule wall disintegration speed and its opacity. In addition, inclusion of gas bubbles into the capsule wall lowers the gelatin content for a foam capsule and provides energy saving during the process due to a faster drying of the wall, thereby providing lower cost prices for the production of pharmaceutically acceptable capsules.

Abstract: A cooling apparatus utilizing liquid nitrogen for cooling specimens to temperatures in the range from -100.degree. C. to -195.degree. C. in propane, halogenated hydrocarbons, isopentane, or other cooling media. Freezing of the cooling media is avoided by means of an arrangement wherein the liquid nitrogen cools the cooling-bath container and/or the liquifier only initially, but after the desired cooling-bath temperature has been reached, the liquid nitrogen level is lowered to below the height of a protective shell which results in further cooling being only indirect, via solid/solid contacts and via the gas phase. A constant cooling-bath temperature is ensured by means of a thermostatic temperature-control system while trouble-free standby operation is ensured by means of an automatic system for replenishing liquid nitrogen, and by a system for controlling the level of liquid nitrogen. Safe disposal of the cooling media which may be combustible and/or toxic is provided for.

Abstract: A microtome, especially an ultramicrotome, is disclosed in which a forward-feed system for the specimen arm and/or knife of the microtome comprises a stepping motor which is controlled by a pulse generator and which shifts the specimen arm, and the knife, relative to each other by an appropriate amount of forward feed in accordance with a forward-feed value which is set at one of a plurality of preselector switches. In order to facilitate quick switching over from one forward-feed amplitude to another, permitting the selection of forward-feed amplitudes which differ by an order of magnitude, for example, if semi-thin sections are to be produced during a run of ultra-thin sections, the forward-feed amplitudes set by the preselector switches can be switched, according to choice, to the pulse generator for the stepping motor by means of a changeover switch. This arrangement enables the operator to alter the forward-feed amplitude by one manual action without disturbing the ongoing operation.

Abstract: A cleansing composition is disclosed that is particularly suited for compaction into tablet form, and comprises a phosphate salt, an optionally added silicate salt, such as a metasilicate and at least one perborate salt, wherein at least a portion of the perborate salt component is present as a compacted, granulated mixture with from about 0.01% to about 0.70% by weight of the perborate salt, of a polymeric fluorocarbon. Preferably, the perborate salt includes sodium perborate monohydrate and anhydrous sodium perborate, and polytetrafluoroethylene comprises the polymeric fluorocarbon used to prepare the granules.When present, the silicate salt is preferably utilized within a particle size ranging from about 1 to about 25 microns. The silicate aids disintegration and assists in mechanical cleaning, when the composition is prepared in tablet form for use as a denture cleanser.

Abstract: A method is disclosed for the preparation of granulated perborate salts having improved utility in compressible compositions such as those formed into denture cleanser tablets. The method broadly comprises forming a mixture of one or more perborate salts such as sodium perborate monohydrate and anhydrous sodium perborate, with a polymeric fluorocarbon such as polytetrafluoroethylene, with the polytetrafluoroethylene present in an amount ranging from about 0.01% to about 0.70% by weight of the perborate salt. The particles thus prepared exhibit combination of improved hardness and specific weight that facilitates their participation in the compressible cleanser composition, together with enhanced disintegration characteristics that are favorably imparted to the cleanser tablets.The present invention also includes the granular salts prepared by the method, which have a broad range of utility in detergents, cleansers and the like.

Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.

Abstract: Novel organic amide compounds which are N-[2-(acylaminophenyl)-4-hydroxy-5-pyrimidinylcarbonyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-2-(acylaminophenyl)-4-hydroxy-5-pyrimidine carboxylic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[2-(acylaminophenyl)-4-hydroxy-5-pyrimidinylcarbonyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

Abstract: Novel organic amide compounds which are N-[6-(acylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[acylaminophenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[acylaminophenyl]-1,2-dihydro-2-oxonicotinoyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

Abstract: Novel organic amide compounds which are N-[6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

Abstract: The present invention relates to (2-oxo-2H-1-benzopyran-3-yl)aminooxoacetic acids and their derivatives having the following structural formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl or nitro and R.sub.2 is hydrogen or lower alkyl and their pharmaceutically acceptable salts thereof; these compounds are indicated in the management of allergic manifestations such as, for example, asthma, hay fever and the like.The present invention relates to (2-oxo-2H-1-benzopyran-3-yl)aminooxoacetic acids and their derivatives having the following structural formula: ##STR2## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl or nitro. R.sub.2 is hydrogen or lower alkyl and their pharmaceutically acceptable salts thereof.

Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.

Abstract: Novel organic amide compounds which are N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl] penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacylamino)-phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(acylaminoacylamino or aminoacylamino) phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

Abstract: The present invention relates to prostaglandin analogues of the general formula: ##STR1## [wherein A represents a grouping of the formula: ##STR2## X represents trans-vinylene or ethylene and Y represents cis-vinylene or ethylene, R represents a group of the formula --COOR.sup.4, in which R.sup.4 represents hydrogen or straight- or branched-chain alkyl of 1 to 12 carbon atoms, or a group of the formula --CH.sub.2 OR.sup.5, in which R.sup.5 represents hydrogen or alkylcarbonyl of 2 to 5 carbon atoms and R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent hydrogen, straight- or branched-chain alkyl of 1 to 12 carbon atoms, or an aryl group unsubstituted or substituted by one, two or three substituents selected from alkyl, alkoxy, alkylthio, monoalkylamino and dialkylamino groups and halogen atoms, the alkyl groups or moieties of the said groups containing from 1 to 5 carbon atoms in a straight- or branched-chain, with the proviso that at least one of the symbols R.sup.1, R.sup.

Abstract: Novel organic amide compounds which are N-[2-[(acylaminoacylamino or aminoacylamino)phenyl]-4-hydroxy-5-pyrimidinylcarbonyl] penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-2-[(acylaminoacylamino or aminoacylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid or (b) reacting the free amino acid of 6-aminopenicillamic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[2-[(acylaminoacylamino or aminoacylamino)phenyl]-4-hydroxy-5-pyrimidinylcarbonyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

Abstract: Substituted tetrahydrobenzazepines and tetrahydronaphthazepines which are useful as pharmacological agents, especially in the treatment of cardiac arrhythmias, are disclosed. These compounds can be prepared by cyclizing an appropriately substituted (.beta.-hydroxy-.beta.-phenylethyl)(.beta.-phenylethyl)amine.

Abstract: A sealed capsule, for example a locking capsule, filled with liquid or other viscous material, in particular a liquid pharmaceutical preparation; and a method for the production of a sealed capsule.

Abstract: This invention relates to a method for the removal of heparin from heparin-containing plasma test samples using an insoluble protamine reaction product, without adversely affecting subsequent testing of the plasma for clotting time. Protamine sulfate or a combination of protamine sulfate and serum albumin is cross-linked with glutaraldehyde to form an insoluble reaction product which is capable of adsorbing heparin. According to the method of this invention, excess amounts of either of the cross-linked protamine reaction products are added to blood plasma samples containing heparin and the mixture is agitated for a time sufficient to permit adsorption of substantially all heparin present. The insoluble protamine heparin complex formed is removed from the plasma along with any excess insoluble protamine reaction product. Aliquots of the heparin-free plasma may be subjected to coagulation tests in order to determine true clotting time.

Abstract: The invention relates to substituted 10-oxo-10H-pyridazino(6,1-b)quinazoline-2-carboxylic acids having the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen; R.sub.2 is hydrogen, lower alkyl containing one to three carbon atoms, or wherein R.sub.1 and R.sub.2 taken together with the carbon atoms to which they are attached in a benzo ring, and the pharmaceutically acceptable salts thereof. These compounds are useful as anti-allergic agents.