Abstract: Certain 4,9-dihydro-9-oxo-N-1H-tetrazol-5-yl-pyrazolo[5,1-b]quinazoline-2-carboxam ides are disclosed. These compounds prevent the allergic response in mammals.

Abstract: A heavy bodied reversible hydrocolloid dental impression material is disclosed. This material comprises agar-agar as the main component in which there is added a small amount of locust bean gum, potassium or zinc sulfate, a borate and nonionic poly(ethyleneoxide)homopolymer. This dental impression material is effective, for example, for bonding to an alginate material.

Abstract: The present invention is concerned with novel 3-hydroxy-pyrrolin-2-one derivatives and with the preparation thereof.

Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.

Abstract: New 3-(3-methoxyphenoxy)-2-pyridinecarbonitriles, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, are disclosed. Other known 3-(3-substituted phenoxy)-2-pyridinecarbonitriles are disclosed having the same utility. The compounds can be produced by dehydrating the appropriately substituted oxime or displacing an alkoxy group to give the desired carbonitrile.

Abstract: A tableted form of fibrous triethylaminoethyl cellulose suitable for the removal of heparin from heparin-containing blood plasma. The tablet is composed of granular microcrystalline cellulose and fibrous triethylaminoethyl cellulose in a ratio of from about 5.4:1 to about 10:1. The triethylaminoethyl cellulose tablet, which is formulated to provide from about 5 to about 26 mg. of triethylaminoethyl cellulose per milliliter of plasma sample, is added to a heparin-containing blood plasma sample, the sample is agitated or allowed to stand for a time sufficient to permit adsorption of substantially all heparin present. The sample is then centrifuged and the remaining heparin-free plasma can be subjected to coagulation testing in order to determine the true clotting time.

Abstract: 5-phenoxy-2-pyridinecarbonitrile compounds, which are useful as pharmacological agents, especially as agents for the reversal of amnesia, and methods for their preparation are disclosed. Pharmaceutical compositions containing said compounds and methods for using said compositions in treating senility and reversal of amnesia are also taught.

Abstract: 9-(2-O-Acyl-.beta.-D-arabinofuranosyl)adenine compounds and their production by enzymatic removal of the 3-O-acyl and 5-O-acyl groups of a 9-(2,3-di-O-acyl-.beta.-D-arabinofuranosyl)adenine compound or a 9-(2,3,5-tri-O-acyl-.beta.-D-arabinofuranosyl)adenine compound. The monoester compounds are useful as antiviral agents. The compounds are water-soluble and lipophilic, thereby being adaptable to a wide variety of pharmaceutical formulations.

Abstract: The present invention relates to 1,5-dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine- 2-carboxamides having the following structural formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl, or nitro and R.sub.2 is hydrogen or lower alkyl and the pharmaceutically acceptable salts thereof.These compounds and their pharmaceutically acceptable salts are useful in the management of allergic manifestations such as bronchial asthma, hay fever and the like.

Abstract: An immunoassay wherein the sample containing an immunologic substance is added to a suspension of particles coated with a second immunologic substance which is specific to the immunologic substance of the sample. The change in percentage of light transmission through the suspension undergoing the resulting agglutination is measured for a predetermined period of time and compared to a standard graph. The suspension is under constant agitation during the measurement.

Abstract: The present invention relates to 1,5-dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine- 3-carboxamides having the following structural formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl or nitro and R.sub.2 is hydrogen or lower alkyl.These compounds and their pharmaceutically acceptable salts are useful in the management of allergic manifestations such as bronchial asthma, hay fever and the like.

Abstract: A method is provided of manufacturing a joined telescoping vented cap-and-body capsule filled with viscous material, comprising the steps of filling the viscous material into the body part, closing the filled body part with a layer of pasty sealing composition which is inert to the viscous material, telescoping the cap and closed body part, and sealing the inner side of the cap to the body part.

Abstract: 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone, 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one and acid-addition salts thereof are disclosed. 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone and its acid-addition salts are prepared by catalytically reducing an acid-addition salt of 2-amino-1-[5-amino-1-(protected)-1H-imidazol-4-yl]ethanone. 6,7-Dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one and its acid-addition salts are prepared by reacting an acid-addition salt of 2-amino-1-(5-amino-1H-imidazol-4-yl)ethanone with a compound able to contribute a formyl group. The later product may subsequently be converted into (R)-3-(2-deoxy-.beta.-D-erythropentofuranosyl)-3,6,7,8-tetrahydroimidazo[4 ,5-d][1,3]diazepin-8-ol. Furanose derivatives of 6,7-dihydroimidazo[4,5-d][1,3]diazepine are also disclosed and their methods of preparation. Lastly, a method for resolving an isomer mixture of 3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4 ,5-d][1,3]diazepin-8-ol compounds is related.

Abstract: 3,4-Dihydro-10-[2-(dialkylamino)ethyl]-1-phenyl-1H-thiazino[4,3-a]indol-4-o l compounds having in free base form the formula ##STR1## where R.sub.1 and R.sub.2 are lower alkyl groups. The compounds of this invention exhibit anti-allergy properties and are indicated in the management of allergy.

Abstract: 3-Aryloxy-1-carboalkoxyethylpyridinium compounds, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, are disclosed. The compounds can be produced by reacting 3-aryloxypyridine with an alkyl acetate containing a displaceable group.

Abstract: 3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds, which are useful as pharmacological agents, especially as agents for the reversal of amnesia, are disclosed. The compounds can be produced by oxidizing a 3-aryloxy-2-pyridinecarbonitrile.

Abstract: A prosthetic preform comprised of a hard base into which are molded the posterior prosthetic teeth, with the anterior prosthetic teeth being mounted in a waxy material contained in a cavity or cavities disposed in the hard base. The preform is further provided with a formable deflectable layer secured to the hard base structure and adapted to be fit to the general contours of the wearer's mouth with an impression material used to line the tissue surface of the deflectable layer to obtain an impression of the intimate detail of the edentulous tissue. The anterior teeth may thus be adjusted in position during fitting and/or anatomical features carved. A mold is made of the anterior teeth and exposed waxy material after fitting which allows casting the fitted anterior teeth in hard base material to the remainder of the hard base structure.

Abstract: Cleaning apparatus for filled capsules including in combination a rotary drum for tumbling the capsules, napped or tufted fabric liner means for the drum such that uncleaned capsules during tumbling are rubbed by the nap of the fabric and are thereby cleansed of particulate matter, and vacuum means for removing particulate matter from the nap of the fabric; and a process for cleaning filled capsules.

Abstract: 3-Aryloxy-substituted-aminopyridines and salts thereof, which are useful as pharmacological agents, especially cognition activators, are disclosed. They can be produced by reacting a chloro-3-aryloxypyridine with a substituted amine, 3-bromo-substituted-aminopyridine with an alkali metal salt of a phenol compound or by deoxygenation of a 3-aryloxy-substituted-aminopyridine N-oxide.

Abstract: A process for the conversion of the major antifungal antibiotic, acid S (ATCC No. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.