Patents Represented by Attorney Suzanne A. Sprunger

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  • Methods of treatment using IL-6
    Patent number: 6284237
    Abstract: IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.
    Type: Grant
    Filed: April 6, 1994
    Date of Patent: September 4, 2001
    Inventors: Steven C. Clark, Gordon G. Wong, Paul Schendel, John McCoy
  • Polynucleotides encoding human CTLA-8 related proteins
    Patent number: 6074849
    Abstract: Polynucleotides encoding human CTLA-8 related proteins are disclosed. Human CTLA-8 proteins and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpesvirus herpes CTLA-8 proteins are also provided.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: June 13, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, Kerry Kelleher, McKeough Carlin, Samuel Goldman, Debra Pittman, Sha Mi, Steven Neben, Joanne Giannotti, Margaret M. Golden-Fleet
  • MU-1, member of the cytokine receptor family
    Patent number: 6057128
    Abstract: Polynucleotides encoding the MU-1 hematopoietin receptor superfamily chain and fragments thereof are disclosed. MU-1 proteins and methods for their production are also disclosed.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: May 2, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: Debra D. Donaldson, Michelle Unger
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5985602
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: November 16, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Cheryl Evans
  • Human semaphorin E, secreted proteins and polynucleotides encoding them
    Patent number: 5981222
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: November 9, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5976837
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: November 2, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Polynucleotides encoding secreted proteins
    Patent number: 5972652
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 26, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg
  • Secreted proteins
    Patent number: 5969093
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: October 19, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, Kerry Kelleher, McKeough Carlin, John M. McCoy
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5969125
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: October 19, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5965388
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: October 12, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans, Michael Bowman
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5965693
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: October 12, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5958726
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: September 28, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg, Maurice Treacy, Cheryl Evans
  • TNF receptor death domain ligand proteins
    Patent number: 5948638
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: September 7, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • Polynucleotides encoding secreted proteins
    Patent number: 5945302
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: January 13, 1997
    Date of Patent: August 31, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg
  • TNF receptor death domain ligand proteins
    Patent number: 5891675
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: April 6, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • TNF receptor death ligand proteins and inhibitors of ligand binding
    Patent number: 5852173
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: September 26, 1995
    Date of Patent: December 22, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding
    Patent number: 5849501
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: December 15, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella
  • TNF receptor death domain ligand proteins and inhibitors of ligand binding
    Patent number: 5843675
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: December 1, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5837490
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: November 17, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5831056
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: November 3, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Michael Bowman, Vikki Spaulding