Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
Type:
Grant
Filed:
June 17, 1996
Date of Patent:
September 15, 1998
Assignee:
Genetics Institute, Inc.
Inventors:
Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans, Vikki Spaulding, Michael Bowman
Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
Type:
Grant
Filed:
August 15, 1996
Date of Patent:
January 27, 1998
Assignee:
Genetics Institute, Inc.
Inventors:
Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham