Abstract: Liposoluble salts of S-adenosyl-L-methionine (SAM) with acyl derivatives of taurine having the formula:SAM.sup.n [R--CO--NH--(CH.sub.2).sub.2 --SO.sup.-.sub.3 ].sub.nin which R--CO is a member selected from C.sub.12 -C.sub.26 saturated and unsaturated, linear and branched acyl, and C.sub.2 -C.sub.26 cycloalkyl-substituted acyl, and n is from 3 to 6 according to the SAM charge, and pharmaceutical compositions containing the salts.
Abstract: This invention concerns compositions for zootechnical and veterinary use, characterized in that biologically active substances are incorporated in protective matrices, which have the following properties: 1) controlled release (ruminal by-pass) effect; 2) chemical-physical protection of active principles against degradation induced by technological processes of production, storage and pellettization of fodders for all animal species. The matrices of the invention are characterized by a plastic rheological behaviour due to the presence of lipogelling agents. The obtained products show the following advantages: increased active principle stability in feeds for all animal species; protection of the active principles from attack of Rumen microorganisms in fodder from attack of for ruminants.
Type:
Grant
Filed:
February 27, 1990
Date of Patent:
November 26, 1991
Assignee:
Industria Italiana Integratori Trei S.p.A.
Abstract: A corrosion inhibitor for aqueous systems containing ferrous and non-ferrous metallic surfaces comprising (a) hydroxyphosphonoacetic acid, or a water soluble salt thereof, and (b) an aminoalkylenephosphonic acid derivative, or a water soluble salt thereof.
Type:
Grant
Filed:
January 16, 1990
Date of Patent:
November 26, 1991
Assignee:
Drew Chemical Corporation
Inventors:
Winston S. Go, Joseph S. Roti, Mark G. Lang, Charles O. Weiss
Abstract: Processes for the preparation of bromocriptine tablets or capsules wherein the active ingredient is protected by inclusion in an excipient or by separated granulation of the excipients and mixing granulate with a mixture of the active ingredient and a excipient having low moisture content.
Type:
Grant
Filed:
March 30, 1990
Date of Patent:
November 19, 1991
Assignee:
Poli Industria Chimica S. p. A.
Inventors:
Luigi Moro, Achille Fiori, Alberto Natali
Abstract: Compounds of the formulaHet-S(O).sub.n -CH.sub.2 -A (I)wherein Het is a substituted imidazolyl, purinyl, thieno-imidazolyl or imidazo-pyridyl group, n is 0 or 1, A is one of the following structures: ##STR1## and their physiologically acceptable salts have antiulcer and gastric acid antisecretory activity.
Type:
Grant
Filed:
March 14, 1990
Date of Patent:
November 19, 1991
Assignee:
Chiesi Farmaceutici S.p.A.
Inventors:
Paolo Chiesi, Vittorino Servadio, Roberta Razzetti
Abstract: The control device of a disc clutch consists of a cylinder (2) and of a piston (1). An orifice (3) makes it possible to feed under pressure into a chamber (17) formed between the cylinder and the piston fluid which comes from the master cylinder actuated by the clutch pedal. Under the pressure of the fluid, the piston (1) moves away from the cylinder (2) and controls the opening of the clutch. The device is arranged directly on the tube (8) surrounding the driveshaft, without any other fastening means. O-ring gaskets (11) make it possible to hold the device on the tube and ensure the damping of possible vibrations.The clutch bearing is incorporated in the free end of the piston (1) in the form of a thrust ring (20) held by a ball-bearing fitting.
Abstract: Non-woven fabrics are manufactured using a carding machine with outlet comb, a blamire feed or spreader/batt-making machine with cylinders for depositing a web of fibers, and one or more needling devices. The surface weight of the web delivered by the carding machine to the blamire feed is modified by varying the speed of the comb as a function of the changing positions of the cylinders whereby a batt of variable surface weight over its width is obtained so as to counteract the distortions of surface weight distribution produced by the needling devices.
Type:
Grant
Filed:
November 24, 1989
Date of Patent:
October 29, 1991
Assignee:
S.A. des Ateliers Houget Duesberg Bosson
Abstract: A compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by fluorination of the suitably protected 6-hydroxy-7-keto-derivatives.
Abstract: Invention concerns 4,5-bisubstituted-2-imidazolone derivatives of formula I ##STR1## and pharmaceutically acceptable salts thereof, having high affinity in vitro for D.sub.2, 5-HT.sub.2, .sub.1 receptors and in vivo activity on central nervous system and antihypertensive activity with negligible secondary effects; methods for the preparation thereof; pharmaceutical formulations containing them.
Type:
Grant
Filed:
January 18, 1990
Date of Patent:
October 22, 1991
Assignee:
Istituto Lusofarmaco d'Italia S.p.A.
Inventors:
Aldo Salimbeni, Giuseppe Cascio, Elso Manghisi
Abstract: Compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by reacting with succinic acid carbonanions the corresponding derivatives which have previously been protected, and subsequently deprotecting and decarboxylating them.
Abstract: The invention concerns the use of fructose-1,6-diphosphate in botany for the formulations of compositions suited for the stimulation of the germination of dormant seeds and of the growth of stem tissues of growing plants.
Type:
Grant
Filed:
March 6, 1990
Date of Patent:
August 13, 1991
Assignee:
Biomedica Foscama Industria Chimico-Farmaceutica S.p.A.
Abstract: A porous, open-pore, hardened, plastic mold for shaping a ceramic article by any of various ceramic shaping methods. The mold is prepared by subjecting a water-in-oil emulsion to hardening in the desired mold shape without breaking the emulsion and then drying the hardened, shaped mold. The emulsion has incorporated in it any of sodium disilicate or disodium tetraborate to accelerate the shaping of the ceramic article in the mold. The emulsion may also have incorporated in it any of microbeads of glass, barite, quartz powder and powdered polymers to reduce the pure volume and increase the mechanical strength of the porous, open-pored hardened, plastic mold.
Type:
Grant
Filed:
March 6, 1990
Date of Patent:
July 23, 1991
Assignee:
Sacmi-Cooperativa Meccanici Imola-Soc. Coop. a r.l.
Abstract: Dextrorphan salts with polycarboxylic organic acids are effectively absorbed by the oral route and can conveniently be formulated in pharmaceutical compositions suitable to the oral administration.
Type:
Grant
Filed:
September 12, 1989
Date of Patent:
May 7, 1991
Assignee:
Prodotti Formenti s.r.l.
Inventors:
Carlos Passarotti, Antonio Fossati, Mauro Valenti, Gianluigi Bandi
Abstract: Novel peptides having anorexigenic and hypotensive activities, of general formula:X--ILE--GLU--LYS--AGR--LEU--LEU--ASP--THR--ILE--W (I)wherein X is an amino acid residue or a peptide chain selected from the group consisting of: ##STR1## and W is a hydroxy or amino group.
Abstract: A process for the optical resolution of 2-hydroxy-3-(4-methoxyphenyl)-3-(2-acetylaminophenylthio)-propionic acid sodium salt by seeding of a supersaturated solution of said salt with one of the enantiomers.
Abstract: Gas-condensation device consisting of an enclosure (3a) and chambers (1,2) for collecting the cooling fluid, the enclosure (3a) containing gases which are at least partially condensable and at least one bundle (3) of horizontal smooth tubes inside which the cooling fluid runs and which are arranged regularly in a bundle and supported by intermediate support plates and/or support grids (3b) situated between the collecting chambers, characterized by the replacement of at least part of an oblique descending row of tubes (3) by shaped elements (20) for catching and removing the condensates and which are each offset in a same direction relative to the upper neighboring element.
Abstract: A corrosion inhibitor for ferrous and non-ferrous aqueous systems comprising any of (1) a naphthenic oil based sodium salt of a triethanolamine alkylsulfamido carboxylic acid, (2) a paraffinic oil based sodium salt of a triethanolamine alkylsulfamido carboxylic acid, (3) a sodium salt of an alkylsulfamido carboxylic acid, and (4) a synergistic mixture of any two of (1), (2) and (3).
Type:
Grant
Filed:
September 21, 1988
Date of Patent:
November 13, 1990
Assignee:
Drew Chemical Corporation
Inventors:
Michael A. Mullins, Robert W. Mueller, Peter A. Thomas
Abstract: A composition for inhibiting metal corrosion in a closed aqueous cooling system comprising an aqueous mixture of (a) a nitrate, (b) a silicate, (c) an acrylate polymer, (d) an amine oxide and (e) tolyltriazole. A preferred embodiment also includes a molybdate.
Abstract: A process for the preparation of 1-alkyl-3-carboxy-4-cinnolones of formula I ##STR1## wherein R and R.sub.1 are electron donor groups and R.sub.3 is an alkyl group, starting from an amine of formula II ##STR2## which is subjected to the following transformations; (1) diazotation;(2) coupling with a cyanoacetic ester;(3) alkylation of the arylhydrazone obtained in (2);(4) hydrolysis of the ester and conversion into acyl chloride;(5) intramolecular cyclization;(6) hydrolysis of the nitrile residue.
Type:
Grant
Filed:
March 23, 1988
Date of Patent:
September 11, 1990
Assignee:
Industria Chimica Profarmaco S.p.A.
Inventors:
Raffaello Fusco, Fulvio L. Piselli, Pier M. Boschi