Abstract: Iron proteinaceous derivatives, obtained from ferric or ferrous salts and lysozyme with glutaric or 1,2-cyclohexanedicarboxylic anhydride and their pharmaceutical use in the oral treatment of iron-deficiency anemia, are described.
Abstract: A process for the optical resolution of 2-hydroxy-3-(4-methoxyphenyl)-3-(2-acetylaminophenylthio)-propionic acid sodium salt by seeding of a supersaturated solution of said salt with one of the enantiomers.
Abstract: Heap leaching of gold/silver ores with an aqueous alkali cyanide solution containing a surfactant hydrolyzable at the pH of the solution, the surfactant being present in an amount sufficient to increase the rate of metal value recovery without adversely affecting the carbon efficiency in the subsequent step of separating the metal cyanide value from the pregnant leach solution by absorption on carbon columns.
Abstract: The present invention relates to a process for potentiating the activity of a conjugate consisting of the A chain of ricin coupled with an antibody directed against human T cells, the said process consisting in adding an effective quality of ammonium chloride to the said conjugate.
Type:
Grant
Filed:
August 31, 1988
Date of Patent:
April 24, 1990
Assignee:
Sanofi
Inventors:
Pierre Casellas, Pierre Gros, Franz Jansen
Abstract: A pharmaceutical composition containing L-.alpha.-glycerylphosphorylcolamine as the principal active ingredient for use in the treatment of chronic cerebral psycho-organic syndromes of the involutive kind or due to cerebrovascular insufficiency.
Abstract: Pharmaceutical compositions for the prophylaxis and therapy of biliary tract calculosis and of biliary dyspepsia, containing as the active principle taurohyodeoxycholic acid, are herein described.
Type:
Grant
Filed:
June 1, 1988
Date of Patent:
April 17, 1990
Assignee:
Pharmaricherche Di Allesandra Tonozzi e C. s.a.s.
Abstract: A porous, open pore, hardened, plastic composition suitable as a replacement for plaster for use as a mold in shaping a ceramic article by any of various ceramic shaping methods prepared by subjecting a water-in-oil emulsion to hardening, without breaking the emulsion, and then drying the hardened product, the emulsion having a viscosity of 1600-5000cP and/or containing 2-12% by weight of an alkali-reactive, water-binding material, the water phase/oil phase ratio providing an open pore volume in the composition equivalent to 10-60% of the total volume of the composition.
Abstract: A pharmaceutical composition comprising as the active principle the piperazine salt of (S) 6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid in highly micronized form, suited carriers in which the active principle is scarcely soluble, surfactants, preserving agents and an hydrophilic, pH-independent, matrix consisting of alkyl derivatives of cellulose and/or polyvinylalcohol. The sustained release of the antiinflammatory compositions allows the treatment of affections by means of a single daily administration of the same.
Abstract: A process for the preparation of undenaturated triple helix collagen, starting form animal tendons or cutis, by extraction with diluted organic acids, precipitation with salts, optional gelation and/or lyophilization, tangential filtration.The obtained collagen shows favorable purity characteristics, is not allergenic and more effective in the healing processes than collagens obtained by known methods.
Abstract: A continuous process for the alkylation of CH-acid compounds with dialkyl carbonates in gas-liquid phase transfer catalysis conditions is described, consisting of contacting a mixture of a CH-acid compound (arylacetonitrile or malonic diester) and of a dialkylcarbonate, optionally added with an inert carrier (constituted by a polar or aprotic polar liquid or by a gas), with a catalytic bed comprising alumina spheres carrying a base and a phase transfer catalyst.
Type:
Grant
Filed:
March 30, 1987
Date of Patent:
January 16, 1990
Assignee:
Consiglio Nazionale Delle Richerche
Inventors:
Enrico Angeletti, Franco Trotta, Pietro Tundo, Paolo Venturello
Abstract: .alpha.-methyl-.alpha.-(3,4-dihydro-1-naphthyl)acetic acid, i.e. dinaproic acid, has such valuable analgesic and antiinflammatory activities, as to be useful in human therapy.
Abstract: Ubidecarenones are effectively dissolved in an aqueous medium using N-acyl-2 amino-ethanesulphonates in which the acyl residue has more than 5 carbon atoms. Cosmetic compositions containing ubidecarenones so solubilized are effective in anti-aging and hydrating treatment.
Abstract: Triterpene saponins of formula ##STR1## wherein R.sub.1 is H or OH and R.sub.2 is a tetrasaccharide, or alternatly pentasaccharide, chain have antiinflammatory, mucolytic and antiedemic activities. Said saponins are isolated from roots and bark of Crossopteryx febrifuga, for instance by precipitating them, in form of a complex with cholesterol or sytosterol, from an alcoholic extract of the vegetal material and by partitioning the precipitate between an apolar solvent, which subtracts the complexing agent and a polar solvent in which saponins are soluble.
Type:
Grant
Filed:
June 26, 1987
Date of Patent:
November 7, 1989
Assignees:
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Inverni Della Beffa Industria Chimico Farmeceutica Derivati Naturali
Inventors:
Piero Foresta, Orlando Ghirardi, Bruno Gabetta, Aldo Cristoni
Abstract: The invention relates to a hyperfiltration membrane containing a supporting layer and a separation layer. The membrane is characterized in that the separation layer consists of a crosslinked monomolecular film of molecules, the molecules of the separation layer in the uncrosslinked state being surfactants or surfactant-like lipoids containing at least one hydrophobic chain and at least one hydrophilic group, the hydrophobic chains of these molecules being oriented mainly perpendicularly to the plane of the membrane and parallel to the diffusion direction after crosslinking and the molecules of the separation layer being crosslinked with one another through functional groups in at least one of their hydrophobic chains and/or through functional groups in at least one of their hydrophilic groups.
Type:
Grant
Filed:
June 22, 1988
Date of Patent:
October 10, 1989
Assignee:
Klaus Heckmann
Inventors:
Klaus Heckmann, Georg Manecke, Beate Pfannenmuller, Klaus Ring, Helmut Ringsdorf
Abstract: The present invention relates to the therapeutical use of a pharmaceutical composition of fructose 1,6-diphosphate (FDP) (sodium salt) which, intravenously administered, treats somatic and psychic manifestations caused by alcoholic intoxication.
Type:
Grant
Filed:
June 20, 1988
Date of Patent:
September 26, 1989
Assignee:
Biomedica Foscama Industria Chimico-Farmaceutica S.p.A.
Abstract: A process for the optical resolution of 2-(6-methoxy-2-naphthyl)propionic acid by seeding a supersaturated solution of the ethylamine salt of said acid.
Abstract: The taurinamide with 2-thenoic acid of formula ##STR1## prepared by reaction of taurine with an acylating derivative of 2-thenoic cid, is useful in human and veterinary medicine.
Type:
Grant
Filed:
August 22, 1988
Date of Patent:
June 20, 1989
Assignee:
Ricerche di Schiena S.n.c. del Dr. Michele G. di Schiena & C.
Abstract: A compound exhibiting anti-inflammatory properties having the formula ##STR1## in which X is H, Hal or CH.sub.3 COO--; R.sub.1 is CH.sub.3 (CH.sub.2).sub.2 CH--; and R.sub.2 and R.sub.3 are separately H or Hal; and a pharmaceutical composition containing the same.
Type:
Grant
Filed:
January 2, 1987
Date of Patent:
May 30, 1989
Assignee:
Sicor Societa' Italiana Corticosteroidi S.p.A.
Abstract: Apparatus for transporting of materials by means of conveyer rollers, with a plurality of roller shafts journalled one behind the other in a lateral support member, wherein several roller shafts are driven by a common drive unit, is disclosed. Each roller shaft is furnished with a member capable of transferring torque and whereby the transport of the material is achieved by way of frictional contact. The conveyer rollers are operatively secured to the roller shafts and the torque transfer members are respectively coupled to the pertaining roller shaft by means of a device capable of transferring frictional force.