Abstract: An optical panel includes stacked optical waveguides having stepped inlet facets collectively defining an inlet face for receiving image light, and having beveled outlet faces collectively defining a display screen for displaying the image light channeled through the waveguides by internal reflection.

Abstract: An optical panel is disclosed. A plurality of stacked planar optical waveguides are used to guide light from an inlet face to an outlet face of an optical panel. Each of the optical waveguides comprises a planar sheet of core material having a central plane. The core material has an index of refraction which decreases as the distance from the central plane increases. The decrease in the index of refraction occurs gradually and continuously.

Abstract: The present invention provides peptides of pRb2/p130 or mutants or fragments thereof which inhibit cdk2 kinase activity. Method of inhibiting cdk2 kinase activity in cells with these peptides are also provided.

Abstract: G protein-coupled receptor kinases (GRK) play an important role in phosphorylating and regulating the activity of G protein-coupled receptors. Complementary DNAs (cDNAs) that encode two novel members of the G protein-coupled receptor kinase (GRK) family are provided in the present invention. These cDNAs encode GRK5 (590 amino acids) and GRK6 (576 amino acids) which represent two new members of the GRK family that have distinct tissue distribution and substrate specificity. The availability of the cDNAs enables the generation of reagents to modulate the activity of endogenous kinases. These include dominant negative mutations and antisense oligonucleotides or stably transfected antisense constructs to block expression of the kinase to generate a cell with a reduced ability to desensitize to various agents. Expression of GRK5 and GRK6 also permits identification of specific inhibitors and activators of these two kinases.

Abstract: A protein which is capable of inhibiting epidermal growth factor-induced cellular proliferation is disclosed, as well as a method of obtaining it from a host cell, and a method of obtaining the same in purified form. Therapeutic uses of, and pharmaceutical compositions containing EGFI, TC4 and CDC25 are also described. In addition, the use of EGFI-related gene therapy is described.

Abstract: A novel skin lightening preparation and its method of use are described. The composition and method are characterized by reduced skin irritation, while providing skin lightening that is at least as effective as known over-the-counter preparations.

Abstract: A topical composition for delivering an effective amount of a pharmaceutically acceptable drug, including laureth-4, propylene glycol, dimethylsorbide, and a pharmaceutically acceptable diluent is described as an improved drug delivery composition. Further, a method of transepithelial delivery of a drug to a human by topical application to the skin of a human of a composition including laureth-4, propylene glycol, dimethylsorbide, a pharmaceutically acceptable diluent of water and ethanol and an effective amount of a pharmaceutically acceptable drug has beneficial delivery effects.

Abstract: A method for the treatment of dry skin by applying an effective amount of thyroid hormone in a pharmaceutically acceptable carrier to the skin.

Abstract: A novel skin lightening preparation and its method of use are described. The composition and method are characterized by reduced skin irritation, while providing skin lightening that is at least as effective as known over-the-counter preparations.

Abstract: A method for the treatment of acne is provided which results in the reduction of vestibular side effects following administration of oral tetracycline antibiotics.

Abstract: The invention relates to the use of zucapsaicin (cis-8-methly-N-vanillly-6-nonenamide), the cis-isomer of capsaicin, to treat myocardial disorders, including the prevention, suppression or reversal of an abnormal cardiac rhythm, such as ventricular tachycardia. In vitro, zucapsaicin exhibits electrophysiologic properties distinct from capsaicin. In contrast to capsaicin, zucapsaicin significantly shortens the action potential duration at a dose of 10.sup.-5 M and has no effect on the amplitude of Phase 1 of the action potential in normal Purkinje cells. Zucapsaicin also prevents the induction of ventricular tachycardia of focal Purkinje origin when given intravenously after coronary occlusion in a dog model of acute myocardial infarction.

Abstract: The present invention provides a method for the semi-continuous production of microcellular foam articles. In a preferred embodiment, a roll of polymer sheet is provided with a gas channelling means interleaved between the layers of polymer. The roll is exposed to a non-reacting gas at elevated pressure for a period of time sufficient to achieve a desired concentration of gas within the polymer. The saturated polymer sheet is then separated from the gas channelling means and bubble nucleation and growth is initiated by heating the polymer sheet. After foaming, bubble nucleation and growth is quenched by cooling the foamed polymer sheet.

Abstract: The present invention provides compositions and methods for alleviation of both visible and non-visible, or pre-emergent, dermatological lesions associated with changes in normal keratinization, cutaneous infection, epidermal formation or pilosebaceous function, such as acne, psoriasis, seborrhea, ingrown hairs and pseudofolliculitis barbae, and hyperpigmented skin. The inventive compositions comprise a dermatologically absorbable topical antimicrobial, antibiotic, antibacterial or antifungal agent; a dermatologically absorbable alpha or beta hydroxy acid; and a dermatologically absorbable zinc compound in a suitable carrier.

Abstract: Antibodies raised against derivatives of inositol are used to assay for specific isomers of inositol in a sample by first converting any inositol present in the sample to the derivative that was used to raise the antibody and then conducting an immunoassay for the inositol derivative in a conventional manner.

Abstract: Remote file transfer applications often involve a situation where a receiving computer (22) contains a reference file (48) that may be similar, or perhaps even identical to, a source file(46) to be transmitted by a sending computer (20). A file transfer method that identifies and isolates the differences between the two files, and transmits only those differences to the receiving computer. The method divides the data in the reference file into a plurality of blocks and associates each block of data with a key value. The key values are then sent to the sending computer in the form of an array. At the sending computer, a block of data at the source file is identified, its key value computed, and the key value is then compared to the keys in the array. If a match is found, an indication of such is sent to the receiving computer. Otherwise, a byte of data from the data block is sent to the receiving computer, and a subsequent block of data is identified and analyzed.

Abstract: A method of treating a cluster of diseases associated with elevated blood sugar levels comprising the administration of a dietary supplement of chiro-inositol. Chiro-inositol is an essential element for the synthesis of an insulin-directed mediator apparently responsible for the activation of pyruvate dehydrogenase-phosphatase. Disease conditions commonly associated with insulin-resistance, such as hypertension, lactic acidosis, obesity, coronary artery disease, and the like, are treated by administration of sufficient chiro-inositol to meet normal metabolic levels.

Abstract: An enhanced quantitative assay for chiro-inositol concentration can be used to determine insulin-resistance, or a predisposition to the development of insulin-resistance, in type I and type II diabetics. Spot urine or serum samples reflecting concentrations of chiro-inositol below about 1.0 micrograms/ml in urine or 0.1 micrograms/ml in serum are indicative of a predisposition to the development of insulin-resistance, while concentrations below about 0.3 micrograms/ml or 0.03 micrograms/ml in serum are associated with actual insulin-resistance symptoms. The assay can be employed for patient diagnosis, insulin therapy monitoring, and family screening.

Abstract: The invention relates to the synthesis of D-chiro-inositol from glucodialdose comprising the steps of condensing glucodialdose by a acylon condensation reaction, protecting the carbon atoms of the 1,2,5 and 6 position, epimerizing the protected carbon atom at position 5, reducing the ketone of the condensed compound and removing the protect groups.