Abstract: An implantable prosthesis for repairing or augmenting anatomical defects, including an inguinal hernia. The prosthesis includes a repair fabric having a body portion and a support member that may be arranged in or on the repair fabric to help deploy the repair fabric at the surgical site and/or help inhibit folding or buckling of the repair fabric. The support member may substantially surround the body portion to help deploy and/or hold the body portion in a spread out configuration for covering the defect. The support member may include first and second ends that are spaced apart to form an interruption so that a slit or keyhole arrangement may be formed in the repair fabric through the interruption and into an interior region of the body portion to receive a body structure, including a cord structure such as the spermatic cord.

Abstract: Compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions such as autoimmune diseases, transplant rejection, and allergic diseases.

Abstract: The present invention generally relates to polymers with lasing characteristics that allow the polymers to be useful in detecting analytes. In one aspect, the polymer, upon an interaction with an analyte, may exhibit a change in a lasing characteristic that can be determined in some fashion. For example, interaction of an analyte with the polymer may affect the ability of the polymer to reach an excited state that allows stimulated emission of photons to occur, which may be determined, thereby determining the analyte. In another aspect, the polymer, upon interaction with an analyte, may exhibit a change in stimulated emission that is at least 10 times greater with respect to a change in the spontaneous emission of the polymer upon interaction with the analyte. The polymer may be a conjugated polymer in some cases. In one set of embodiments, the polymer includes one or more hydrocarbon side chains, which may be parallel to the polymer backbone in some instances.

Abstract: A memory system for use with a master-slave type bus such as an AHB bus has a memory, a bus interface to allow memory access from the bus, and a direct memory access interface to allow memory access from a DMA controller without occupying the bus. The system can reduce occupancy of the bus, it can allow dedicated DMA access protocols faster than the bus protocol to be used, and can remove or reduce the need for bus arbitration and associated circuitry and delays. An arbiter can arbitrate between the memory accesses and give priority to DMA accesses.

Abstract: Disclosed and claimed herein is a sports fantasy game, having a roster of fantasy players for each user, and a slot machine-like apparatus that provides a limited number of spins for populating the roster of fantasy players. Also disclosed herein is a method of conducting the above described game. Further described and claimed are various modifications and enhancements.

Abstract: Stand, in particular camera stand, comprising: a receptacle for mounting an apparatus, in particular a camera; and at least one leg which is connected to the receptacle and comprises at least two telescopic units (T1, T2), of which a first telescopic unit (T1) is connected to the receptacle and a second telescopic unit (T2) is displaceable relative to the first telescopic unit and can be locked in a desired position in relation to the first telescopic unit (T1), characterized in that two locking points set apart in the longitudinal direction of the leg are provided between the second telescopic unit (T2) and the first telescopic unit (T1) for locking the telescopic units (T1, T2).

Abstract: Certain types of reciprocating positive-displacement pumps (which may be referred to hereinafter as “pods,” “pump pods,” or “pod pumps”) are used to pump fluids, such as a biological fluid (e.g., blood or peritoneal fluid), a therapeutic fluid (e.g., a medication solution), or a surfactant fluid. The pumps may be configured specifically to impart low shear forces and low turbulence on the fluid as the fluid is pumped from an inlet to an outlet. Such pumps may be particularly useful in pumping fluids that may be damaged by such shear forces (e.g., blood, and particularly heated blood, which is prone to hemolysis) or turbulence (e.g., surfactants or other fluids that may foam or otherwise be damaged or become unstable in the presence of turbulence).

Abstract: This invention relates to modified IGF-II binding domains of the Insulin-like Growth Factor 2 Receptor (IGF2R) which have enhanced binding affinity for IGF-II relative to the wild type IGF-II binding domain. Suitable IGF-II binding domains may be modified, for example, by substituting residue E1544 for a non-acidic residue. These modified domains may be useful in the sequestration of Insulin-like Growth Factor II (IGF-II), for example, in the treatment of cancer.

Abstract: The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides a more efficient route for preparing the enone intermediate.

Abstract: Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a therapeutically acceptable amount of a fatty acid metabolism inhibitor and/or a therapeutically acceptable amount of a glucose metabolism inhibitor, optionally in combination with one or more chemotherpeutic agents. In preferred embodiments, the invention combines an antibody against UCP and/or Fas antigen with an oxirane carboxylic acid, represented by etomoxir, and/or with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers.

Abstract: Artesunate is a derivative of artemisinin isolated from a Chinese herb Artemisia annua L. It is used clinically for the treatment of malaria. We investigated potential anti-inflammatory actions of artemisinin derivatives. artemisinin derivatives significantly inhibited OVA-induced signs, symptoms and parameter of airway disorders Taken together, our results clearly demonstrate anti-inflammatory effects of artemisinin derivatives. Artemisinin derivatives can be used to complement or to replace oral steroids during asthma exacerbation treatment. Further artemisinin derivatives can be used as an anti-inflammatory agent for controlling airway disorders.

Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Abstract: The present invention relates to chemical compounds of general formula (I) which may possess useful therapeutic activity in a range of central nervous system disorders, and in particular, anxiety disorders.

Abstract: A camera support device includes: a first rotating member to which an imaging device is fixed; a second rotating member having first and second arm portions interposing the first rotating member therebetween and supporting the first rotating member turnable by the first and second arm portions; a support member interposed between the first and second arm portions and supporting the second rotating member turnably; an operation member changing a distance between the first and second arm portions; a first engagement portion formed by a serration formed on a contact surface of at least one of the first and second arm portions and the first rotating member; and a second engagement portion formed by a serration formed on a contact surface of at least one of the first and second arm portions and the support member and being set to have an engagement depth different from that of the first engagement portion.

Abstract: Imagers, pixels, and methods of using the same are disclosed for imaging in various spectra, such as visible, near infrared (IR), and short wavelength IR (SWIR). The imager may have an imaging array having pixels of different types. The different types of pixels may detect different ranges of wavelengths in the IR, or the SWIR, spectra. The pixels may include a filter which blocks some wavelengths of radiation in the IR spectrum while passing other wavelengths. The filter may be formed of a semiconductor material, and therefore may be easily integrated with a CMOS pixel using conventional CMOS processing techniques.

Abstract: A fabric receiving element for a blind assembly, the fabric receiving element having at least two axially extending slots, each slot defining an opening for receiving blind material, the openings being of different respective widths, the slots including a floor opposite the openings, and wherein the middle portion of the floor of the slot is at a greater distance from the opening than the end portions of the floor of the slot.

Abstract: The present invention relates to a nano-particle biochip substrate comprising a substrate having attached thereto (bearing), on or in a surface, nano-particles having a cross sectional diameter of from about 0.1 nm. to about 50 nm. and useful to immobilize one or more moieties of interest.

Abstract: A system and method may be disclosed for facilitating the creation or modification of a document by providing a mechanism for locating relevant data from external sources and organizing and incorporating some or all of said data into the document. In the method for reusing data, there may be a set of documents that may be queried, where each document may be divided into a plurality of sections. A plurality of section text groups may be formed based on the set of documents, where each section text group may be associated with a respective section from the plurality of sections and each section group includes a plurality of items. Each item may be associated with a respective section from each document of the set of documents. A selected item within a selected section text group may be focused. The selected item may be extracted to a current document. The current document may be exported to a host application.

Abstract: Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.

Abstract: A comparison circuit can reduce the amount of power consumed when searching a load queue or a store queue of a microprocessor. Some embodiments of the comparison circuit use a comparison unit that performs an initial comparison of addresses using a subset of the address bits. If the initial comparison results in a match, a second comparison unit can be enabled to compare another subset of the address bits.