Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.
Type:
Grant
Filed:
June 13, 2016
Date of Patent:
May 21, 2019
Assignee:
23andMe, Inc.
Inventors:
Chuong Do, Eric Durand, John Michael MacPherson, Brian Thomas Naughton, Joanna Louise Mountain
Abstract: Assembling a cohort includes: receiving genetic characteristic information pertaining to a desired genetic characteristic; using the genetic characteristic information to search a data storage comprising information of previously genotyped individuals to derive a candidate group having the desired genetic characteristic; and assembling the cohort based at least in part on the candidate group.
Type:
Grant
Filed:
July 1, 2016
Date of Patent:
December 25, 2018
Assignee:
23andMe, Inc.
Inventors:
Arnab Chowdry, Alexander Kompel, Michael Polcari
Abstract: Determining relative connections between individuals includes: obtaining identification information of a first individual and identification information of a second individual; determining, based at least in part on a relative connections graph, a relative connections path connecting the first individual, the second individual, and at least one additional individual; and outputting information pertaining to the relative connections path.
Abstract: Error correction in ancestry classification includes obtaining, from a classifier, initial ancestry classifications associated with portions of two phased haplotypes of a chromosome pair of an individual; performing error correction on an initial ancestry classification, including detecting a phasing error in the initial ancestry classifications; and outputting a corrected ancestry classification in which the phasing error is corrected.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
May 22, 2018
Assignee:
23andMe, Inc.
Inventors:
Chuong Do, Eric Durand, John Michael Macpherson
Abstract: Displaying a comparison of genotypic information between relatives is disclosed, including receiving an indication that a first individual is a grandparent, receiving an indication that a second individual is a grandchild of the first individual, comparing the genotypic information of the first individual and the second individual and calculating a similarity score, and displaying an indication of the similarity score graphically using colors.
Type:
Grant
Filed:
October 15, 2008
Date of Patent:
January 9, 2018
Assignee:
23andMe, Inc.
Inventors:
Linda Avey, Oleksiy Khomenko, Brian Thomas Naughton, Serge Saxonov, Anne Wojcicki, Alexander Wong
Abstract: Phasing unphased genotype data of an individual includes: obtaining the unphased genotype data of the individual; processing the unphased genotype data to determine phased haplotype data, the processing comprising performing out-of-sample population-based phasing on the unphased genotype data; wherein: performing out-of-sample population-based phasing includes performing statistical analysis using predetermined reference data that is based on genotype data of a reference population; and the genotype data of the reference population does not reference the genotype data of the individual.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
December 5, 2017
Assignee:
23andMe, Inc.
Inventors:
Chuong Do, Eric Durand, John Michael Macpherson
Abstract: Assembling a cohort includes: receiving genetic characteristic information pertaining to a desired genetic characteristic; using the genetic characteristic information to search a data storage comprising information of previously genotyped individuals to derive a candidate group having the desired genetic characteristic; and assembling the cohort based at least in part on the candidate group.
Type:
Grant
Filed:
February 17, 2015
Date of Patent:
August 2, 2016
Assignee:
23andMe, Inc.
Inventors:
Arnab Chowdry, Alexander Kompel, Michael Polcari
Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
June 14, 2016
Assignee:
23andMe, Inc.
Inventors:
Chuong Do, Eric Durand, John Michael Macpherson
Abstract: Sharing data is disclosed. In some cases, sharing data includes receiving a request to share data from a first account to a second account, receiving an indication of a plurality of first account profiles associated with the first account to share with the second account, and establishing sharing from the plurality of first account profiles to the second account, wherein sharing comprises the second account having read access to a subset of nonpublic data associated with the plurality of first account profiles.
Type:
Grant
Filed:
October 14, 2008
Date of Patent:
May 10, 2016
Assignee:
23andMe, Inc.
Inventors:
Brian Lee Hawthorne, Oleksiy Khomenko, Jeffrey Mellen, Marcela Miyazawa, Michael Polcari, Jack Tihon, Alexander Wong, Anne Wojcicki, Linda Avey
Abstract: Processing genetic data includes receiving two or more genetic data sets for an individual from one or more genetic data sources, wherein the genetic data sets comprises data pertaining to the individual's deoxyribonucleic acid (DNA); merging the genetic data sets from the one or more genetic data sources to obtain a set of merged genetic data for the individual, including: identifying data in the genetic data sets that is conflicting, the identified data corresponding to a genetic marker associated with a variation that occurs at a region in the individual's genome; analyzing the identified data to resolve a discrepancy attributed to the identified conflicting data and automatically determine an appropriate value that corresponds to the genetic marker, the analysis and the determination being based at least in part on contextual information; and storing the appropriate value in the set of merged genetic data.
Type:
Grant
Filed:
December 9, 2013
Date of Patent:
December 22, 2015
Assignee:
23andMe, Inc.
Inventors:
Alexander Wong, Oleksiy Khomenko, Serge Saxonov, Brian Thomas Naughton, Lawrence Hon
Abstract: Ancestry deconvolution includes obtaining unphased genotype data of an individual; phasing, using one or more processors, the unphased genotype data to generate phased haplotype data; using a learning machine to classify portions of the phased haplotype data as corresponding to specific ancestries respectively and generate initial classification results; and correcting errors in the initial classification results to generate modified classification results.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
December 15, 2015
Assignee:
23andMe, Inc.
Inventors:
Chuong Do, Eric Durand, John Michael Macpherson
Abstract: Performing trio-based phasing includes: obtaining a set of preliminary phased haplotype data of an individual; establishing a dynamic Bayesian network based at least in part on the set of preliminary phased haplotype data of the individual and phased haplotype data of at least one parent of the individual; and determining, based on the dynamic Bayesian network, a set of refined haplotype data of the individual.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
December 15, 2015
Assignee:
23andMe, Inc.
Inventors:
Chuong Do, Eric Durand, John Michael Macpherson
Abstract: Determining relative relationships among a plurality of individuals, comprising: accessing user-specified genealogical information of at least some of the plurality of individuals and genetic information of recombinable deoxyribonucleic acids (DNAs) of at least some of the plurality of individuals; determining, using one or more computer processors and among the plurality of individuals, one or more related individuals who are relatives of a target individual, and information pertaining to the one or more related individuals, and presenting information pertaining to at least one of the one or more related individuals, including to present an indication of whether the at least one of the one or more related individuals is a matrilineal relative or a patrilineal relative of the target individual.
Type:
Grant
Filed:
March 14, 2013
Date of Patent:
August 25, 2015
Assignee:
23andMe, Inc.
Inventors:
John Michael Macpherson, Michael Polcari, Brian Thomas Naughton
Abstract: Assembling a cohort includes: receiving genetic characteristic information pertaining to a desired genetic characteristic; using the genetic characteristic information to search a data storage comprising information of previously genotyped individuals to derive a candidate group having the desired genetic characteristic; and assembling the cohort based at least in part on the candidate group.
Type:
Grant
Filed:
October 11, 2011
Date of Patent:
March 24, 2015
Assignee:
23andMe, Inc.
Inventors:
Arnab Chowdry, Alexander Kompel, Michael Polcari