Patents Assigned to Agilent Technologies, Inc.
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Patent number: 11494988Abstract: Novel tools and techniques are provided for implementing augmented reality (AR)-based assistance within a work environment. In various embodiments, a computing system might receive, from a camera having a field of view of a work environment, first images of at least part of the work environment, the first images overlapping with a field of view of a user wearing an AR headset; might analyze the received first images to identify objects; might query a database(s) to determine a task associated with a first object(s) among the identified objects; might generate an image overlay providing at least one of graphical icon-based, text-based, image-based, and/or highlighting-based instruction(s) each indicative of instructions presented to the user to implement the task associated with the first object(s); and might display, to the user's eyes through the AR headset, the generated first image overlay that overlaps with the field of view of the user's eyes.Type: GrantFiled: May 21, 2019Date of Patent: November 8, 2022Assignee: AGILENT TECHNOLOGIES, INC.Inventors: Amir Ben-Dor, Elad Arbel, Richard Workman, Victor Lim
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Patent number: 11491419Abstract: A gas-liquid separator includes a fluid inlet, a shell including an inside surface enclosing an interior space, an outlet structure with fingers converging toward a longitudinal axis, and a dripper including a dripper tip. The fingers terminate at fingertips located proximate to an outside surface of the dripper. Gas exit ports are defined between adjacent fingers, and by the dripper. The gas-liquid separator defines a liquid flow path from the fluid inlet, along the inside surface, along one or more of the fingers, converging along the dripper outside surface, and to the dripper tip. The gas-liquid separator also defines a gas flow path from the fluid inlet, through the interior space, and through the gas exit ports. The gas-liquid separator may be utilized in fluid separation systems such as liquid chromatography or supercritical fluid chromatography/extraction systems.Type: GrantFiled: August 15, 2016Date of Patent: November 8, 2022Assignee: Agilent Technologies, Inc.Inventors: Edwin E. Wikfors, Samuel O. Colgate
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Publication number: 20220351475Abstract: Novel tools and techniques are provided for implementing augmented reality (AR)-based assistance within a work environment. In various embodiments, a computing system might receive, from a camera having a field of view of a work environment, first images of at least part of the work environment, the first images overlapping with a field of view of a user wearing an AR headset; might analyze the received first images to identify objects; might query a database(s) to determine a task associated with a first object(s) among the identified objects; might generate an image overlay providing at least one of graphical icon-based, text-based, image-based, and/or highlighting-based instruction(s) each indicative of instructions presented to the user to implement the task associated with the first object(s); and might display, to the user's eyes through the AR headset, the generated first image overlay that overlaps with the field of view of the user's eyes.Type: ApplicationFiled: July 18, 2022Publication date: November 3, 2022Applicant: AGILENT TECHNOLOGIES, INC.Inventors: Amir Ben-Dor, Elad Arbel, Richard Workman, Victor Lim
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Patent number: 11480181Abstract: The invention relates to a vacuum system, comprising a vacuum pump, preferably turbomolecular pump, and at least one vacuum chamber, wherein the vacuum pump comprises: at least a first and a second inlet and a common outlet; at least a first and a second pumping stage, each pumping stage comprising at least one rotor element being arranged on a common rotor shaft, wherein the first inlet is connected to an upstream end of the first pumping stage and the second inlet is connected to an upstream end of the second pumping stage; a direction element for preventing a gas flow from a downstream end of the first pumping stage to the second inlet; a conduit having a conduit inlet and a conduit outlet, wherein the conduit inlet is connected to the downstream end of the first pumping stage and the conduit outlet is connected to a location downstream of the second pumping stage; wherein the first inlet and the second inlet of the pump are connected to the same vacuum chamber.Type: GrantFiled: July 7, 2020Date of Patent: October 25, 2022Assignees: PFEIFFER VACUUM GMBH, AGILENT TECHNOLOGIES, INC.Inventors: Tobias Stoll, Michael Schweighoefer, Jan Hoffmann, James L. Bertsch
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Patent number: 11466314Abstract: Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as a rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.Type: GrantFiled: November 19, 2019Date of Patent: October 11, 2022Assignee: Agilent Technologies, Inc.Inventors: Jesper Lohse, Mike Paw Maischnack Hansen
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Publication number: 20220318345Abstract: Novel tools and techniques are provided for implementing software licensing management and authentication. In various examples, a computing system might receive a request for an unlock code for a requested service from a user using a client device on which a first software is executed, the request comprising a generated unique identifier associated with the requested service and/or the first software. The generated unique identifier comprises licensing information associated with the requested service and/or the first software. In response to receiving the generated unique identifier, the computing system might determine whether the user should have access to the requested service using the first software based at least in part on the licensing information. If so, the computing system might generate an unlock code associated with the requested service using the first software, might deduct cost associated with the licensing information, and might send the unlock code to the user.Type: ApplicationFiled: May 21, 2020Publication date: October 6, 2022Applicant: AGILENT TECHNOLOGIES, INC.Inventors: Dustin BINGHAM, Charles MANFREDI
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Publication number: 20220301842Abstract: In some examples, a multi-device removal and installation tool may include a device removal tool including catch members engageable with an engagement face of a device to attach, upon engagement of the catch members with the engagement face, the device removal tool to the device. The catch members may engage the engagement face with a removal force that is sufficient to remove, upon engagement of the catch members with the engagement face, the device from an instrument. The multi-device removal and installation tool may further include a torque limit tool including a retainer having at least one protrusion, and a drive member having an inside surface and an outside surface. The torque limit tool may further include at least one detent positioned on the inside surface.Type: ApplicationFiled: March 16, 2021Publication date: September 22, 2022Applicant: AGILENT TECHNOLOGIES, INC.Inventor: Alan D. LOUX
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Patent number: 11443933Abstract: An inductively coupled plasma-mass spectrometry (ICP-MS) system includes an ion trap, in which ions are trapped and subsequent ejected by mass-selective ejection (MSE). The system may have a linear quadrupole configuration, in which the ion trap is a linear ion trap (LIT) that is preceded by a pre-LIT linear quadrupole device and/or a post-LIT quadrupole device. The pre-LIT and/or post-LIT quadrupole device may be configured or operated as an RF-only ion guide or as a mass filter or mass analyzer, with or without mass scanning. The system may be utilized in particular for multi-element analysis of fast transient signals produced from ion pulses, where the sample under analysis is a single particle, single biological cell, or a cloud or aerosol produced for example by single-shot laser ablation.Type: GrantFiled: November 23, 2020Date of Patent: September 13, 2022Assignee: Agilent Technologies, Inc.Inventor: Noriyuki Yamada
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Patent number: 11442038Abstract: The invention is an improved multiplex capillary electrophoresis instrument or module with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. An additional mechanical stage moves the array from side-to-side. The x-z stage, coupled with the additional array stage allows the system to sample all wells of a 384 well plate with a 96-capillary array. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress.Type: GrantFiled: June 13, 2018Date of Patent: September 13, 2022Assignee: Agilent Technologies, Inc.Inventors: Bruce R. Boeke, Martin Chris Foster, Thomas J. Kurt, Scott Stueckradt, Steven J. Lasky
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Patent number: 11435328Abstract: One aspect of the invention provides a gas chromatography union including: a first port; a second port in fluid communication with the first port; and a first pair of wings defining a first recess. Another aspect of the invention provides a union including: a first port; a second port in fluid communication with the first port; and at least a first protrusion defining a first recess. Another aspect of the invention provides a coupler including: a first port; a second port in fluid communication with the first port; and a first connector positioned on a portion of a surface of the coupler.Type: GrantFiled: February 28, 2020Date of Patent: September 6, 2022Assignee: AGILENT TECHNOLOGIES, INC.Inventors: Allen K. Vickers, Ngoc A Thi Dang, David Jantz
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Publication number: 20220276208Abstract: A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.Type: ApplicationFiled: May 20, 2022Publication date: September 1, 2022Applicant: AGILENT TECHNOLOGIES, INC.Inventors: Edward D. MROZ, Heng HE
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Publication number: 20220274757Abstract: A package (100), including a base (150) having at least one receptacle (151), in which the at least one receptacle (151) includes a first portion (154) having a first diameter (D1) and a second portion (152) having a bottom surface and a second diameter (D2) is disclosed. A method for removing a product from the package is also disclosed.Type: ApplicationFiled: February 24, 2022Publication date: September 1, 2022Applicant: AGILENT TECHNOLOGIES, INC.Inventors: Olga SCHIKURSKI, Lucas Serge, Qi Siegmundt-Pan, Michael Wherry, Thorsten Dressler, Daniela Loraing, Thomas Dumoulin
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Patent number: 11418228Abstract: A circuit and method for providing high-voltage radio-frequency (RF) energy to an instrument at multiple frequencies includes a plurality of inputs each configured to receive an RF voltage signal oscillating at a corresponding frequency, and a step-up circuit for generating magnified RF voltage signals based on the received RF voltage signals. The step-up circuit includes an LC network operable to isolate the RF voltage signals at the plurality inputs from one another while preserving a voltage magnification from each input to a common output at each of the corresponding frequencies.Type: GrantFiled: July 10, 2020Date of Patent: August 16, 2022Assignee: AGILENT TECHNOLOGIES, INC.Inventor: Michael J. Schoessow
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Patent number: 11414695Abstract: A method of enriching for a fragment of a genome, as well as corresponding compositions and kits, are provided. In certain embodiments, the method comprises: (a) contacting a sample comprising fragmented DNA with a Cas9-gRNA complex comprising mutant Cas9 protein that has inactivated nuclease activity and a Cas9-associated guide RNA that is complementary to a site in the DNA, to produce a Cas9-fragment complex that comprises a fragment of the fragmented DNA; and (b) isolating the complex. In addition, other methods and compositions for Cas9/CRISPR-mediated nucleic acid manipulation are also provided.Type: GrantFiled: May 29, 2014Date of Patent: August 16, 2022Assignee: Agilent Technologies, Inc.Inventors: Brian Jon Peter, Robert A. Ach
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Patent number: 11410303Abstract: Novel tools and techniques are provided for implementing digital microscopy imaging using deep learning-based segmentation and/or implementing instance segmentation based on partial annotations. In various embodiments, a computing system might receive first and second images, the first image comprising a field of view of a biological sample, while the second image comprises labeling of objects of interest in the biological sample. The computing system might encode, using an encoder, the second image to generate third and fourth encoded images (different from each other) that comprise proximity scores or maps. The computing system might train an AI system to predict objects of interest based at least in part on the third and fourth encoded images. The computing system might generate (using regression) and decode (using a decoder) two or more images based on a new image of a biological sample to predict labeling of objects in the new image.Type: GrantFiled: April 10, 2020Date of Patent: August 9, 2022Assignee: Agilent Technologies Inc.Inventors: Elad Arbel, Itay Remer, Amir Ben-Dor
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Publication number: 20220242896Abstract: The present invention provides methods and kits to improve the signal from sialic acids labeled with the dye 1, 2-diamino-4, 5-methylenedioxybenzene (“DMB”). The methods include labeling the sialic acids with DMB in an aqueous solution comprising the amino acid glycine, with pH adjusted to 1.5-3.2 by an acid, such as phosphoric acid or hydrochloric acid, and a reductant.Type: ApplicationFiled: June 6, 2020Publication date: August 4, 2022Applicant: Agilent Technologies, Inc.Inventor: Francis T. Haxo
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Patent number: 11390907Abstract: Provided herein is a method for making a pool of probes by primer extension. In certain embodiments, the method comprises hybridizing a first population of oligonucleotides comprising a top strand sequence having the following formula V1-B-3? with a second population of oligonucleotides comprising a bottom strand sequence having the following formula V2?-B?-3? to provide a population of duplexes. After hybridizing, the 3? ends of the oligonucleotides in the duplexes are extended to produce a population of double stranded products comprising a top strand sequence having the following formula V1-B-V2, where V2 is complementary to V2?.Type: GrantFiled: March 5, 2013Date of Patent: July 19, 2022Assignee: Agilent Technologies, Inc.Inventors: Michael Ruvolo, Emily Marine Leproust
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Publication number: 20220220544Abstract: The present disclosure is generally directed to detecting nucleic acids. In particular, disclosed herein are methods and compositions for determining the sequence (or identity) and location of RNA and other molecules in situ. The present invention is generally related to a method for detecting nucleic acids, the method including providing a tissue sample; providing an array comprising a plurality of oligonucleotide probes attached to a surface of the array, in which each oligonucleotide probe, of the plurality of oligonucleotide probes, includes a location barcode sequence, a primer binding sequence, and a priming sequence; releasing the plurality of oligonucleotide probes from the array surface; contacting the tissue sample with the released oligonucleotide probes; and allowing the released oligonucleotide probes to diffuse into the tissue sample.Type: ApplicationFiled: January 7, 2022Publication date: July 14, 2022Applicant: AGILENT TECHNOLOGIES, INC.Inventors: Robert A. ACH, Nicholas M. SAMPAS, Brian Jon PETER
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Publication number: 20220214334Abstract: The present invention provides methods to improve the sensitivity of detecting glycosylamines released from glycoconjugates, such as glycoproteins or glycopeptides, by enzymatic digestion when labeling them with amine-reactive dyes.Type: ApplicationFiled: April 30, 2020Publication date: July 7, 2022Applicant: Agilent Technologies, Inc.Inventor: Andres Guerrero Navarro
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Patent number: RE49207Abstract: Provided herein, among other things, are a variety of methods for transposase-mediated tagging and amplification of short DNA fragments, e.g., between about 150 bp and 1.5 Kb in length. In some aspects, the method includes tagging the DNA fragments with a first primer sequence using barcoded transposases followed by a primer extension reaction to introduce a second primer sequence, e.g., using random or gene-specific primers. Kits for performing this method are also provided.Type: GrantFiled: November 8, 2019Date of Patent: September 13, 2022Assignee: Agilent Technologies, Inc.Inventors: Bahram Arezi, Michael Borns, Holly Hogrefe, Connie Hansen