Abstract: Compositions and methods for genetically modifying at least one nucleic acid sequence of interest in a polyploid organism.

Abstract: Imaging a distribution of one or more optical sources includes: receiving respective optical signals from a spatial mode sorter during each of two or more detection intervals of time; after each of the two or more detection intervals of time, processing information based at least in part on: (1) the respective optical signal received in the corresponding detection interval of time, and (2) a first set of models comprising a set of distributions related to one or more optical sources, each model corresponding to a different number of optical sources in the distribution, and configuring the spatial mode sorter based at least in part on the processing; and providing an estimated measurement characterizing the distribution of one or more optical sources based at least in part on the processed information. The processing after at least one of the two or more detection intervals of time includes computing an eigen-projection.

Abstract: Disclosed herein are methods of assessing a population's health using wastewater samples. For example, the methods assess exposure to pathogens, plasticizers, volatile organic compounds, surfactant, hazardous chemical, nicotine, and/or other environmental toxins. In some aspects, the methods determine the concentration of disease biomarkers, chemical biomarker, certain human hormones, certain genes, pharmaceuticals, illicit drugs, personal care product, pathogens, and/or endogenous mental health markers. In some aspects, the methods assess population health at a neighborhood level. The methods may also be used to assess population health at a larger regional level, for example at a state level or a national level.

Abstract: A system for providing a contour map of the surface of a heliostat from reflected sunlight using a fly's eye camera. The system includes an entrance screen configured to receive sunlight reflected by said heliostat; an array of imaging apertures extending across the entrance screen, each aperture forming an image of said heliostat from a different viewpoint to provide a plurality of heliostat images; one or more digital cameras configured to view all of said plurality of heliostat images; an image processor configured to map out from the plurality of heliostat images a location of sunlight delivered to the entrance screen to obtain a plurality of maps, and to provide, based on centroids of said maps a tip and tilt of each said subsection The reflecting surface profile of the heliostat is obtained by integration of the subsection tilts across all the subsections.

Abstract: The disclosure relates to the production of methyl laurate by genetically engineered photosynthetic microorganisms. In particular, provided herein are methods and compositions for producing methyl laurate from carbon dioxide and water in genetically engineered cyanobacteria and other photosynthetic microorganisms.

Abstract: Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.

Abstract: A method of making a metal-polymer composite includes dealloying metallic powder to yield porous metal particles, monitoring a temperature of the mixture, controlling the rate of combining, a maximum temperature of the mixture, or both, and combining the porous metal particles with a polymer to yield a composite. Dealloying includes combining the metallic powder with an etchant to yield a mixture. A metal-polymer composite includes porous metal particles having an average particle size of about 0.2 ?m to about 500 ?m and a thermoplastic or thermoset polymer. The polymer composite comprises at least 10 vol % of the porous metal particles. A powder mixture includes porous metal particles having an average particle size of about 0.2 ?m to about 500 ?m and a metal powder. The powder mixture includes about 1 wt % to about 99 wt % of the porous metal particles.

Abstract: Programmable interposers for connecting integrated circuits, methods for programming programmable interposers, and integrated circuit packaging are provided. The programmable interposers are electrically reconfigurable to allow custom system-in-package (SiP) operation and configuration, field configurability, and functional obfuscation for secure integrated circuits fabricated in non-trusted environments. The programmable interposer includes, in one implementation, an interposer substrate and a programmable metallization cell (PMC) switch. The PMC switch is formed on the interposer substrate and is coupled between a signal input and a signal output. The PMC switch is electrically configurable between a high resistance state and a low resistance state.

Abstract: A system and method for controlling boundary layer transition for a high-speed vehicle are disclosed. The method includes determining a location of onset of boundary-layer transition that naturally develops during high-speed flight of the high-speed vehicle, and providing a pair of flow control strips at a surface/wall/skin of the high-speed vehicle such that the boundary-layer transition is delayed or prevented during high-speed flight of the high-speed vehicle. The delayed or prevented locations of the transition result in a change in the high-speed boundary layer during the high-speed flight of the high-speed vehicle. The change in the high-speed boundary layer transition affects skin friction drag, aero-thermodynamic heating, and pressure fluctuations in the boundary layer of the high-speed vehicle.

Abstract: The present invention provides monoclonal antibodies against SARS-CoV-2 and methods of use and making thereof.

Abstract: Tracking-based motion deblurring via coded exposure is provided. Fast object tracking is useful for a variety of applications in surveillance, autonomous vehicles, and remote sensing. In particular, there is a need to have these algorithms embedded on specialized hardware, such as field-programmable gate arrays (FPGAs) or application-specific integrated circuits (ASICs), to ensure energy-efficient operation while saving on latency, bandwidth, and memory access/storage. In an exemplary aspect, an object tracker is used to track motion of one or more objects in a scene captured by an image sensor. The object tracker is coupled with coded exposure of the image sensor, which modulates photodiodes in the image sensor with a known exposure function (e.g., based on the object tracking). This allows for motion blur to be encoded in a characteristic manner in image data captured by the image sensor. Then, in post-processing, deblurring is performed using a computational algorithm.

Abstract: An adapter for a container that provides an integrated photoacoustic microscopy system that is capable of real time imaging of samples within the container. The adapter allows a researcher or investigator to evaluate a sample using the photoacoustic effect, with or without a microscope. The adapter comprises a support portion, a planar portion, and a tube. The support portion includes a channel formed therein, the channel including a first surface, a second surface opposite the first surface, and an intermediate surface positioned between the first surface and the second surface, the channel configured to receive the rim of the container such that the intermediate surface of the channel is positioned adjacent a top surface of the rim and the first surface and the second surface extend along opposite sides of the sidewall. The planar portion is coupled to the support portion and extends across the opening of the container.

Abstract: Systems, methods, and apparatuses to restore degraded speech via a modified diffusion model are described. An exemplary system is specially configured to train a diffusion-based vocoder containing an upsampler, based on pairing original speech x and degraded speech mel-spectrum mT samples; train a deep convoluted neural network (CNN) upsampler based on a mean absolute error loss to match the estimated original speech {circumflex over (x)}? outputted by the diffusion-based vocoder by extracting the upsampler, generating a reference conditioner, and generating a weighted altered conditioner cTn?. The system further optimizes speech quality to invert non-linear transformation and estimate lost data by feeding the degraded mel-spectrum mT through the CNN upsampler and feeding the degraded mel-spectrum mT through the diffusion-based vocoder. The system then generates estimated original speech {circumflex over (x)}? based on the corresponding degraded speech mel-spectrum mT. Other related embodiments are described.

Abstract: A bioproduct manufacturing system is disclosed. The system comprises a hollow-fiber primary membrane gas absorber comprising a shell side and a lumen, wherein the primary membrane gas absorber is configured to receive a carbonate salt-based solvent on the shell side and a gas mixture comprising oxygen, nitrogen, and carbon dioxide in the lumen, at least one runway algal cassette reactor-photobioreactor, and a growth medium circulating between the primary membrane gas absorber and the at least one runway algal cassette reactor-photobioreactor. The at least one runway algal cassette reactor-photobioreactor comprises at least one growth chamber coupled to and in fluid communication with a headspace channel so as to define and interior volume, a first condenser coupled to and in fluid communication with the headspace channel, and a harvest line in fluid communication with the at least one growth chamber and coupled to a filter.

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

Abstract: Solvent free epoxy systems are disclosed that can include a hardener compound H comprising: a molecular structure (R1—(Y1)n), wherein R1 is an ionic moiety, Y1 is a nucleophilic group, n is a between 2 and 10; and an ionic moiety A acting as a counter ion to R1; and an epoxy compound E comprising: a molecular structure (R2—Z1)n), wherein R2 is an ionic moiety, Z1 comprises an epoxide group, n is a between 2 and 10, and an ionic moiety B acting as a counter ion to R2. In embodiments, the epoxy compound E and/or the hardener H is comprised in a solvent-less ionic liquid. The systems can further include accelerators, crosslinkers, plasticizers, inhibitors, ionic hydrophobic and/or super-hydrophobic compounds, ionic hydrophilic compounds, ionic transitional hydrophobic/hydrophilic compounds, biological active compounds, and/or plasticizer compounds. Polymers made from the disclosed epoxy systems and their methods of use are described.

Abstract: This present disclosure is directed to a silver metal wire coated with silver sulfide reference electrode, the preparation via anodization of a silver metal wire in a sodium and/or potassium sulfide solution and use thereof, including test methods to measure corrosion in test articles such as metal pipes. The reference electrode exhibits good stability characteristics, including stability under high temperature conditions.

Abstract: Systems, devices and methods for predicting binding on an array such as a peptide array. Certain methods utilize a peptide array having a plurality of peptides with one or more defined parameters and contacting the peptide array with a training sample containing one or more molecules of interest. Interactions between the plurality of peptides and the one or more molecules of interest are processed according to a data fitting model, which model is then is applied to interactions between the plurality of peptides and a test sample to predict binding associated with the one or more molecules of interest.

Abstract: A method of calculating an abundance of an mRNA sequence within a gene comprises storing an index table of the gene in a non-volatile memory, obtaining a short read of the mRNA sequence, generating a set of input fragments from the mRNA sequence, initializing a compatibility table in a volatile memory, for each input fragment in the set of input fragments, searching for an exact match of the input fragment in the index table, calculating a final result from the compatibility table, and calculating an abundance of the mRNA sequence in the gene by aggregating the transcripts compatible with the short read, wherein the calculating step is performed on the same integrated circuit as the non-volatile memory. A system for in-memory calculation of an abundance of an mRNA sequence within a gene is also disclosed.

Abstract: A system for in-memory computing comprises a volatile memory comprising at least a first layered subarray, wherein each subarray comprises a plurality of memory cells, and a plurality of sub-sense amplifiers connected to a read bitline of the first subarray of the memory, configured to compare a measured voltage of the read bitline to at least one threshold and provide at least one binary output corresponding to a logic operation based on whether the voltage of the read bitline is above or below the threshold. A method for in-memory computing is also disclosed.