Abstract: The present invention encompasses ophthalmic compositions that may be used for various conditions of the eye, and particularly, conditions of the cornea. Also encompassed are methods that utilise these compositions and kits that include these compositions.

Abstract: An IPT track arrangement including a power supply and conductor electrically connected to the power supply, the conductor includes a plurality of loops located substantially adjacent one another, wherein the polarity in adjacent portions of the loops is the same, and wherein the power supply includes a one or more inverters which share the track load.

Abstract: Embodiments of the invention involve combining data representative of the eye obtained from multiple modalities into a virtual model of the eye. The multiple modalities indicate anatomical, physiological, and/or functional features of the eye. The data from different modalities is registered in order to combine the data into the virtual model. Further embodiments involve analysing eye data, for example in the form of the virtual model, using neural networks to obtain insights about medical conditions of the eye, for example the diagnosis or prognosis of conditions, and/or predicting how the eye will respond to certain treatments.

Abstract: A wireless power transfer apparatus for capacitive-inductive power transfer has a primary and a secondary device separated by the conductive member. The primary device has at least two transmitter plates configured to be capacitively coupled with the conductive member to induce a current flow and generate a magnetic field in the conductive member. The secondary device is connectable to a load and provided with a receiving coil configured to be inductively coupled with the conductive member.

Abstract: Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.

Abstract: The invention relates to substituted imidazo[4,5-c]pyridine-2-one compounds of Formula (I) and prodrugs of said compounds. Compounds of Formula (I) selectively inhibit the activity of DNA-dependent protein kinase (DNA-PK) and are therefore useful in the treatment of diseases in which inhibition of DNA-PK is beneficial.

Abstract: The invention relates to protein ligation technologies, purified or recombinant peptides, methods for making peptides and proteins with covalent bonds including reversible covalent bonds such as reversible intermolecular covalent bonds, and uses thereof. In particular, this invention relates to intermolecular ester bonds, particularly reversible ester bonds between the hydroxyl and amide groups of amino acid side chains present in recombinant chimeric peptides and proteins and the use of such peptides and proteins in protein engineering, for example in the preparation of multimeric protein complexes, including functionalised multimeric protein complexes.

Abstract: An IPT system magnetic flux pad includes two substantially planar coils (17) in close proximity to each other above a magnetically permeable core (14). The coils (17) each define a pole area (11, 12) and the distance between one or more adjacent turns of the coils (17) located in a region between the pole areas (11, 12) being different from the distance between one or more adjacent turns of the coils (17) located outside the region between the pole areas (11, 12).

Abstract: The present disclosure relates to a boost active bridge converter, which has particular, but not sole, relevance to a converter for an inductive or capacitive (wireless) power transfer system. According to an embodiment An AC-AC converter is presented. The AC-AC converter comprises a bridge circuit including at least two half-bridge converters, each half bridge converter comprising a first switch at an upper end and a second switch at a lower end, a capacitor connected to each half-bridge converter, the half bridge converters being connected to each other between the respective first switches and second switches thereof, the upper ends of each half bridge converters being connectable to a primary energy source, wherein the converter is operable to provide a controllable AC output.

Abstract: A wireless coupling structure has a first layer comprising a flux coupling coil having two opposing end regions separated by two opposing side regions; a second layer comprising a first block of ferrite and a second block of ferrite; and a third layer comprising a leakage flux control coil. The first block is provided next to one of the end regions and the second block is provided next to the other of the end regions.

Abstract: This invention relates to a vortex station and method for producing a vortex similar to one of a group consisting of dust-devils and waterspouts. The apparatus comprises a ground platform forming a base for the vortex station, a plurality of vanes to direct an air flow into a vortex station and about the vortex station in a substantially swirling manner, at least one wind turbine disposed near the centre of said vortex station, in a path of a concentrated air flow, wherein the movement of the air in the vortex station is such that an atmospheric buoyancy vortex is created in the centre of the vortex station, a supply of a working fluid (e.g. water) to the vortex station at or near the centre of the vortex station such that the air is of a saturated condition or an at least partially saturated condition with the working fluid (e.g. water), the working fluid (e.g. water) supplied at a sufficient quantity or amount so as to assist with maintaining buoyancy and stability of a vortex created.

Abstract: A pressure sensor apparatus includes a plurality of pressure responsive chambers provided along a longitudinal dimension of the apparatus, and a pressure sensor device provided in each chamber which together provide a pressure profile in an anatomical cavity.

Abstract: A method of mercury-free photochemical micro-/nano-encapsulation of an active material is a process for obtaining Micro-/nano-capsules by means of curing by UV LED radiation at ambient or even cold temperatures. A stirrer photo-reactor made from glass or transparent plastics can be used but mixed flow reactor could be also employed. Appropriate mixing is sufficient to expose all droplets, which contain an active material surrounded by curable-shell materials in the emulsion to the LED radiation. Using the optimum light intensities and reactions' times is critical for encapsulating the active material with a high efficiency and producing a high quality micro-/nano-capsules, Solar monochromator device can also be used as long as it generate the same radiation with a narrow/single wavelengths as the LED device.

Abstract: A roadway powered electric vehicle system includes a power supply (101) which makes power available inductively to one or more modules (111) provided in or under a roadway. Modules (111) make a magnetic field selectively available to one or more vehicles travelling over the roadway corresponding to the location of the vehicle. The presence or strength of the magnetic field provided on the roadway may be dependent upon the vehicle type or category.

Abstract: A circuit for energizing a magnetic flux coupling apparatus has a pick-up coil for receiving power inductively, a storage capacitor for storing energy from the received power, and an inverter for supplying electrical energy from the storage capacitor to the magnetic flux coupling apparatus. The circuit allows power transfer to a load to be supplied by the flux coupling apparatus to exceed the power received from the pick-up.

Abstract: A magnetic structure for wireless power transfer has a plurality of pieces of magnetically permeable material arranged along a first dimension. Each piece is separated from a neighbouring piece by a gap defining a separation distance which is selected to prevent partial saturation of a region of the structure.

Abstract: The present disclosure relates to an integrated boost modular multilevel converter, which has particular, but not sole, relevance to a converter for an inductive or capacitive (wireless) power transfer system. More particularly, the present invention according to an embodiment discloses a modular multilevel power converter (MMPC) comprising: at least one submodule stack having an output for connection to a load and an input for connection to an input power source, at least one inductive element provided between the input and the output, the at least one submodule stack including at least two submodules, each submodule comprising at least one capacitor and a plurality of controllable switches, and the submodules being operable to selectively transfer energy from the at least one inductive element to boost a voltage at the output relative to a voltage at the input.

Abstract: An inductive or wireless power transfer coupler array has at least two coupler modules connected in parallel to a common power source. Each coupler module comprises a resonant circuit, including at least one transmitter coil and a capacitive element. Each of the coupler modules is connected to a second terminal of the power source across the respective resonant circuit by a corresponding pair of switching elements, and each coupler module is linked with at least one other coupler module at a shared one switching element of the corresponding pair of switching elements. A control module is configured to effect control between the active state and the passive state by controlling the phase angle of the corresponding pair of switching elements.

Abstract: The present invention provides a multi-coil inductive power transfer primary comprising a plurality of coil. A power transfer regime is selected based on a determined load on each of the plurality of coils.

Abstract: A flexible switch has a deformable body and a plurality of electrodes, at least one of the electrodes being provided on the deformable body. The switch has a first state in which the electrodes are spaced apart and a second state in which the electrodes are in electrical contact, and the switch is configured to allow movement between the states when a force is applied to or removed from the deformable body.