Abstract: An Inductive Power Transfer System pickup provides a controlled AC power supply by controlled variation of the phase angle between the pickup coil induced voltage (jwMI) and the tuning capacitor C voltage. The phase angle can be varied by maintaining the tuning capacitor C voltage substantially constant for a selected time period. Switches S1 and S2 may be used to clamp the tuning capacitor C voltage at substantially zero volts during the selected time period. Switch S1 can be operated to prevent a rise in positive voltage across the tuning capacitor, and switch S2 can be used to prevent the voltage across the tuning capacitor from going negative.

Abstract: A device for use in pressure sensing has a housing enclosing a chamber and having at least one port that communicates with the chamber. A pressure sensor receives fluid pressure from the chamber. The chamber has a compliance that exhibits a marked change in volumetric stiffness repeatably at a fixed pressure.

Abstract: The present invention provides novels method of targeting delivery of a compound to hypoxic cells, for example treatment of diseases and disorders associated with hypoxia, comprising administration of a construct comprising a targeting carrier peptide and a compound for delivery to a hypoxic cell. The invention also provides novel methods for the treatment of diseases or disorders of the eye by administration of a novel construct, a nucleic acid encoding a novel construct, and/or a nucleic acid vector comprising a nucleic acid encoding a novel construct. The invention further provides novel constructs, nucleic acids encoding such constructs, and/or nucleic acid vectors comprising nucleic acids encoding such constructs.

Abstract: The invention relates to amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by the methods, and pharmaceutical compositions comprising the conjugates. Methods of eliciting immune responses in a subject and methods of vaccinating a subject, uses of the conjugates for the same, and uses of the conjugates in the manufacture of medicaments for the same are also contemplated.

Abstract: A converter including a bridge circuit having a first leg and a second leg, each leg including a high switch and a low switch, the high switches being connected to a first energy source and the low switches being connected to ground, a coupling network(s) having a first connection between the switches of the first leg and a second connection between the switches of the second leg, and a second (or multiple secondary) energy source(s) connected between the coupling network(s) and ground, wherein the coupling network comprises a first inductive element connected between the second energy source and the switches of the first leg, and a second inductive element connected between the second energy source and the switches of the second leg.

Abstract: The disclosure provides a wireless power transfer circuit that uses two coupled resonators provided in one of a primary or secondary wireless power transfer magnetic structure. The coupled resonators work together to compensate for changes in relative position. Each resonator has a planar coil, and the resonators are coupled with each other by magnetic coupling of the planar coils, which are located adjacent each other in either a side by side relationship or a partially overlapping relationship. The circuit is tolerant to misalignment of the magnetic structures (often referred to as pads) which magnetically couple with each other to enable the transfer of power. The changes in inductances as well as main, cross, and inter coupling between the coils of the primary and pick-up pads or structures show that a constant power transfer or charging profile can be maintained over a large operating region.

Abstract: A device for use in pressure sensing such as hydrocephalus shunts, having a housing enclosing a chamber with at least one port communicating with the chamber. A wall of the chamber includes a flexible portion or thin diaphragm that deflects with transitions in pressure to contact an upstand structure of the housing. A pressure sensor is contained within an enclosure sealed from the chamber by a flexible membrane and which receives fluid pressure from the chamber. This arrangement allows for calibration of the device by identifying a knee feature in pressure data associated with the diaphragm making contact with the upstand.

Abstract: Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: A method of detecting a wirelessly powered vehicle on a roadway uses detection of induced voltages or currents in coils provided in the roadway. Once the vehicle has been detected the appropriate coils can be energised to power the vehicle.

Abstract: The inventions relate to the use of hemichannel blockers to modulate cytokine levels in a subject, including the angiogenic cytokine, VEGF, and their production, secretion and/or release, and to the use of hemichannel blockers to reduce or level cytokine activity, including in conditions characterized in whole or in part by angiogenesis and/or vessel leak.

Abstract: An inductive charging apparatus includes a primary conductor with at least one node for creating a magnetic field and at least one intermediate resonant circuit including a first coil for receiving inductive power from the node, a second coil operable in use to be driven by current from the first coil to generate a magnetic field for power transfer, and a tuning capacitor coupled to the first and second coils for resonance therewith.

Abstract: Optimising water use in a way that avoids over watering or at least avoids or minimises water mobilisation may be useful. An irrigation control system is described, the system including a sound emitter arranged to emit sound towards a ground surface; a sound receiver arranged to receive sound emitted by the sound emitter and reflected or scattered from the ground surface. A controller then controls one or more irrigation parameters of an irrigator based at least in part on sound received by the sound receiver. In a further aspect, the irrigation control system senses the onset of surface water pooling or free water flow on the ground surface and the controller then controls irrigation parameters to reduce application of water in response to the sensed features. Related methods of controlling irrigation systems are also described.

Abstract: A method of charging a battery includes coupling an electricity network or subnetwork to the battery using inductive power transfer, transferring electrical energy to the battery from the electricity network or subnetwork and varying the inductive power transfer using a controller of the electricity network or subnetwork according to at least one predetermined criteria of the electricity network or subnetwork.

Abstract: A polyphase inductive power transfer system primary or secondary apparatus includes a magnetic coupling coil associated with each phase and a compensation network associated with each magnetic coupling coil for providing power to or receiving power from the respective coil. At least one of the compensation networks has a different power transfer characteristic to one or more of the other compensation networks.

Abstract: Disclosed herein is an inductive power transfer (IPT) compensation circuit and method for reflecting a controlled reactance to a primary conductor at a selected operating frequency, compensating for reactive loads reflected to the primary conductor by one or more other pick-ups inductively coupled with the primary conductor in use. The compensation circuit comprises a first switch means coupled to a resonant circuit and operable to reflect a capacitive reactance to the primary conductor; a second switch means coupled to the resonant circuit and operable to reflect an inductive reactance to the primary conductor; and control means adapted to control operation of the first and second switch means to compensate for inductive and capacitive reactances, respectively, in the primary conductor.

Abstract: An inductive power transfer (IPT) converter has a first switching means adapted to produce a time varying input power signal comprising a substantially unipolar stepped waveform, and a second switching means adapted to modify the time varying input power signal provided by the first switching means to produce a modified input power signal. The converter is coupled to a resonant circuit to receive the modified input signal.

Abstract: A system and method for stimulus & eye tracking, useful for the determination of the presence or strength of optokinetic nystagmus (OKN) typically for assessing visual acuity, comprises providing a novel visual stimulus effective to elicit OKN, which includes varying the visibility of a visual stimulus element, or displaying a series of visual stimulus elements so that a later displayed element has different visibility relative to an earlier displayed element. Visual stimulus elements may vanish or appear by reducing or increasing intensity, contrast, size and/or width of the elements or element boundaries. Visual stimulus elements comprise a perimeter that is darker than a background and a centre that is lighter than the background, and/or a perimeter that is lighter than a background and a centre that is darker than the background.

Abstract: Fibroblast Growth Factor Receptor kinase inhibitors and prodrugs thereof of Formula (I) and their use for the treatment of hyper-proliferative diseases such as retinopathy, psoriasis, rheumatoid arthritis, osteoarthritis, septic arthritis, tumour metastasis, periodontal disease, corral ulceration, proteinuria, coronary thrombosis from atherosclerotic plaque, aneurismal aorta, dystrophobic epidermolysis bullosa, degenerative cartilage loss following traumatic joint injury, osteopenias mediated by MMP activity, tempero mandibular joint disease, and demyelating disease of the nervous system.

Abstract: An IPT primary or secondary circuit includes a converter connected to a primary energy source and a compensation network. A supplementary energy source is connected to the compensation network and the converter transfers energy between the primary energy source or another IPT primary or secondary circuit and the supplementary energy source.